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TERMINÉ
SYSTEMS-BASED VIEW OF MELANOMA PROGRESSION: TOWARDS NOVEL DIAGNOSTIC (AND THERAPEUTIC) APPLICATIONS (SYS-MEL)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis a ...
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TERMINÉ
Regulation of RNA polymerase III transcription by Id proteins and E47 (Id and Pol III)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,
The Id (Inhibitor of differentiation) family consists of four related transcription factors that are expressed at high levels in rapidly proliferating cells, including those found tumour cells. Overexpression of Id proteins in transgenic mice causes cancers. Ids have been shown to inhibit differentiation and promote cell proliferation in a variety of systems. This is achieved through interactions ...
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