17 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Taking Force Microscopy into the Third Dimension (3D-FM)
Date du début: 1 août 2008, Date de fin: 31 juil. 2013,
...name AFM) is usually limited to measuring the surface topography and surface properties of a specimen, I will demonstrate that Force Microscopy can achieve true 3D images of the structure of the cell nucleus. In Ultrasound Force Microscopy, an ultrasound wave is launched from below towards the surface of the specimen. After the sound waves interact with structures beneath the surface of the specim ...
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1
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TERMINÉ
Targeting IGF-1 receptor in liver cancer with focus on its mechanistic role in transcription and its interaction with the cell cycle machinery (IGF1RHC)
Date du début: 31 mars 2010, Date de fin: 30 mars 2012,
...hibits IGF-1R signaling. An oral IGF-1R inhibitor of cyclolignan chemistry is presently studied in patients with advanced cancer. Recently, they found that IGF-1R is SUMOylated, translocated to the nucleus, where it affects transcription. This is a novel and original function for IGF-1R and one of the goals of this proposal is to further study whether it is limited to tumor cells. In such case, th ...
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TERMINÉ
Novel on-line composting monitoring system (COMPO-BALL)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2013,
...omposting of household recycled waste. This would allow for a higher economic return, and smaller composting plants could be considered. Smaller composting plants could be located closer to the urban nucleus, which would reduce transport costs."
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17
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TERMINÉ
Optogenetic investigation of GABAergic interneurons in the limbic system during reward and addiction (Opto-REW)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,
...f the limbic system that is manifested in a reduced ability to experience pleasure and learning and memory impairment.Dopamine is important in the limbic system, which includes structures such as the nucleus accumbens, ventral tegmental area and prefrontal cortex. Drugs such as opiates and cocaine, but also antidepressant agents, and deep brain stimulation can possibly recruit certain types of int ...
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1
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TERMINÉ
Single Molecule Imaging of the DNA Damage Response in Live Cells (SMI-DDR)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
"Accurate DNA replication is key to maintaining genomic stability. Replication is immensely complex requiring error-free duplication of several billion bases each time a human cell divides. The DNA replication machinery must deal with a wide range of DNA damage, aberrant secondary structures and DNA:protein complexes; obstacles that cause replication forks to arrest. Arrested replication complexes ...
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TERMINÉ
THE ENZYMATIC MACHINERY OF HUMAN MITOCHONDRIAL DNA MAINTENANCE (REPMIT)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
...ode for 13 of the about 90 proteins present in the respiratory chain. All proteins necessary for mtDNA replication, as well as transcription and translation of mtDNA-encoded genes, are encoded in the nucleus. Mutations in nuclear-encoded proteins required for mtDNA maintenance is an important cause of neurodegeneration and muscle diseases. The common result of these defects is either mtDNA deplet ...
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1
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TERMINÉ
Machine learning approaches to epigenomic research (Epigene Informatics)
Date du début: 16 mai 2012, Date de fin: 30 avr. 2015,
Epigenomic research has become one the fastest evolving fields in molecular biology. Epigenetic effects control the packaging of DNA in the nucleus thereby deeply influencing gene expression. They also play crucial roles in cell differentiation and aberrant patterns are associated with cancer, mental disorders and autoimmune diseases. However, our understanding of the epigenomic code is still limi ...
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TERMINÉ
Late Stage Fluorination for Positron Emission Tomography Applications (FLUOPET)
Date du début: 16 avr. 2012, Date de fin: 15 avr. 2015,
...tes severe restrictions on the chemical synthesis of PET tracers. Fluoride introduction must occur at a late stage of the synthesis, ideally as the last step, to avoid unproductive decay of the [18F] nucleus before injection into the body. Due to the limited functional group compatibility with conventional fluorination reactions employed today and the short half-life, the synthesis of PET tracers ...
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1
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TERMINÉ
Chromatin Fiber and Remodeling Factor Structural Studies (CFRFSS)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"DNA in higher organisms is organized in a nucleoprotein complex called chromatin. The structure of chromatin is responsible for compacting DNA to fit within the nucleus and for governing its access in nuclear processes. Epigenetic information is encoded chiefly via chromatin modifications. Readout of the genetic code depends on chromatin remodeling, a process actively altering chromatin structure ...
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1
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TERMINÉ
Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function (JELLY)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,
...s.This project focuses on two types of biomolecular hydrogels: (i) the nuclear pore permeability barrier, a nanoscopic protein meshwork that regulates all macromolecular transport into and out of the nucleus of eukaryotic cells, and (ii) extracellular hydrogel-like matrices that are scaffolded by the polysaccharide hyaluronan and that are of prime importance in a wide range of physiological and pa ...
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2
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TERMINÉ
CONtrast through metal-enriched polymer SALTs: novel contrast agents for dual-energy micro-computed tomography (CONSALT)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
...ther 3D morphology parameters). Novel specific and functional contrast agents (stains) are essential to achieve the 3D visualization of specific pathological cellular or sub-cellular structures (e.g. nucleus or cytoskeleton). The design, development and testing of such new contrast agents to overcome the challenges of contrast enhancement and selectivity for certain tissue and cellular structures ...
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TERMINÉ
Decoding Stress Resilience (DE-STRESS)
Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,
...ncept known as resilience. There is a growing body of experimental data which has implicated several brain structures and molecular mechanisms. However to date there has been limited focus on the bed nucleus of the stria terminalis (BNST) and the mechanisms in this brain region which could be involved. One of several proteins expressed by the BNST, which is a key regulator of the stress response, ...
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1
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TERMINÉ
...ht to enable the development of advanced course styles of highest quality, optimally tailored to the pedagogical and content needs of the students and of the respective local education system. This nucleus is thought to initiate an inherent dynamics in extending the method to production engineering educationas a broader subject.The main results of the Production CyberCollege will be an ICT-based e ...
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5
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TERMINÉ
ECOTONE â Management of riparian habitats towards the conservation of endangered invertebrates (ECOTONE)
Date du début: 1 janv. 2012, Date de fin: 1 janv. 2016,
...mposition;
Increasing dragonfly populations through the settlement of aquatic plants by reconnecting 5 ha of old waterbeds and improving 2 ha of new areas;
Reinforcing the population nucleus of M. Margaritifera by adding 4 500 juvenile individuals to the estimated 500 adults thought to exist in the area;
Reinforcing the population nucleus of U. crassus by adding 400 juvenile individuals to the ...
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1
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TERMINÉ
GREEN BELT. A proposal for sustainable territorial planning (ANELLA VERDA)
Date du début: 1 sept. 2001, Date de fin: 1 sept. 2004,
...nned urban development.
PILOT SCHEME IN MOLLET DEL VALLÃS
- Conversion of land considered suitable for urban development and that would undoubtedly end up being absorbed into the urban nucleus of Mollet del Vallès, into a periurban greenbelt. Intervention of this kind will not only save this land from housing developments, but will also make it profitable through an envisaged education pr ...
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1
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TERMINÉ
EasySpeak
Date du début: 1 sept. 2014, Date de fin: 31 août 2016,
The ability to communicate with prospective new business partners is a fundamental language skill that is frequently lacking within EU countries where companies, particularly SMEs, are seeking global business opportunities. For the life sciences industry this is a known barrier to business growth.
EasySpeak is a 2-year activity that will develop a core vocabulary of 500 words and phrases in those ...
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5
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TERMINÉ
European Biotechnologies Common Tools (BIO-CT)
Date du début: 1 mars 2009, Date de fin: 31 août 2011,
"This project deals with the necessity in the EU to build a system that enables entrepreneurs or academia Technology Transfer Offices to achieve, in the best conditions of rapidity and cost effectiveness, the Industrial Proof of Concept (I-PoC) that enables a real economic valorization of Research achievements (Scientific Proof of concept-Sci-PoC). This early stage development is considered world ...
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