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 TERMINÉ 

Early-life stressors and LifeCycle health (LIFECYCLE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer an unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of non-communicable diseases. LIFECYCLE will establish the Eur ...
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 19

 TERMINÉ 

Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial (PAPA-ARTIS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in ...
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 26

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,

Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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 13

 TERMINÉ 

Arrhythmias monitoring and comprehensive care (RITMOCORE)

Date du début: 1 nov. 2016, Date de fin: 31 déc. 2020,

...will be used to shape the Business Case and the High Level Specifications in RITMOCORE.RITMOCORE procurers are leading cardiac care hospitals: Sant Pau in Barcelona (Spain), Liverpool Heart and Chest NHS Hospital (UK), Elisabeth-TweeSteden Hospital (NL) and the Regional Healthcare Trust of the Marche Region, with its hospital in Fermo (IT).
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 9

 TERMINÉ 

Development of DIALIVE, a novel Liver Dialysis Device for the treatment of patients with Acute on Chronic Liver Failure (ACLF) (ALIVER)

Date du début: 1 janv. 2017, Date de fin: 30 sept. 2020,

Liver disease incidence is increasing and about 170K patients die from liver failure each year in Europe. In liver failure, the accumulation of protein bound toxins and increased susceptibility to infection cause multiorgan failure and death. Liver transplantation is the only treatment known to prolong the life but is limited by availability of organs. A clinically efficacious ‘liver dialysis devi ...
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 12

 TERMINÉ 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 TERMINÉ 

A Federated Collaborative Care Cure Cloud Architecture for Addressing the Needs of Multi-morbidity and Managing Poly-pharmacy (C3-Cloud)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2020,

C3-Cloud will establish an ICT infrastructure enabling a collaborative care and cure cloud to enable continuous coordination of patient-centred care activities by a multidisciplinary care team and patients/informal care givers. A Personalised Care Plan Development Platform will allow, for the first time, collaborative creation and execution of personalised care plans for multi-morbid patients thro ...
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 12

 TERMINÉ 

Evaluating mHealth technology in HIV to improve Empowerment and healthcare utilisation: Research and innovation to Generate Evidence for personalised care (EmERGE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

EmERGE will develop a mHealth platform to enable self-management of HIV in patients with stable disease. The platform will build upon and integrate the existing mHealth solutions operated by pioneering healthcare providers in the UK and Spain and apply a rigorous co-design approach to ensure patient and clinician input to the solution. The platform will provide users with web based and mobile devi ...
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 13

 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Meaningful Integration of Data, Analytics and Services (MIDAS)

Date du début: 1 nov. 2016, Date de fin: 29 févr. 2020,

The MIDAS consortium is a partnership involving health authorities in five EU countries and the U.S. and technical big data experts from research institutions, MNCs and SMEs. Managing big data for ‘health in all’ is a monumental challenge for policy makers. MIDAS is addressing this challenge by developing and delivering an integrated solution which will liberate knowledge from data silos and unify ...
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 17

 TERMINÉ 

Designing for People with Dementia: designing for mindful self-empowerment and social engagement (MinD)

Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,

This project aims to help people with dementia engage in social contexts to improve psychosocial wellbeing. People who are affected by Alzheimer’s disease or other dementias often face cognitive, behavioural and psychosocial difficulties, including impairment and degeneration of memory and of perceptions of identity. In a social context, this can cause difficulties of recognizing, relating to and ...
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 12

 TERMINÉ 

European Security in Health Data Exchange (SHiELD)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

SHiELD will unlock the value of health data to European citizens and businesses by overcoming security and regulatory challenges that today prevent this data being exchanged with those who need it. This will make it possible to provide better health care to mobile citizens across European borders, and facilitate legitimate commercial uses of health data.The exchange of health data is already possi ...
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 11

 TERMINÉ 

Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes (iHealth-T2D)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinica ...
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 13

 TERMINÉ 

DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID) (SCIDNET)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for ...
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 13

 TERMINÉ 

Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac ...
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 14

 TERMINÉ 

Brain injury and trauma monitoring using advanced photonics (BitMap)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Our vision is to develop a suite of standardised non-invasive devices that will provide essential information about brain health in neurocritical care and neuromonitoring, with a particular emphasis on 1. traumatic brain injury: the “silent epidemic of the third millennium” and 2. hypoxia in newborn children. Survivors present permanent neurological conditions that have a profound impact on the qu ...
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 11

 TERMINÉ 

A pEdiatRic dosimetRy personalized platfORm based on computational anthropomorphic phantoms (ERROR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The main objective of ERROR is to develop a new software tool, which will offer to the clinician the possibility to assess alternative imaging and therapeutic protocols, in real time, in silico, in order to minimize patient dose, while maintaining image quality of therapeutic effect. This tool will be designed, implemented and evaluated with specific focus on pediatric patients, since this is a ra ...
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 5

 TERMINÉ 

Glaucoma – Advanced, LAbel-free High resolution Automated OCT Diagnostics (GALAHAD)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

The project GALAHAD targets the critical need for better glaucoma diagnostic systems. Glaucoma is an age-related major cause of blindness. The eye disease is characterized by an irreversible damage to the optic nerve head caused by increased intra-ocular pressure. The current screening and basic diagnostics for the disease involve intra-ocular pressure measurement, visual field tests and detection ...
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 10

 TERMINÉ 

EVidenced based management of hearing impairments: Public health pΟlicy making based on fusing big data analytics and simulaTION. (EVOTION)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2019,

Hearing Loss (HL) is one of the most prevalent chronic diseases and the 5th cause of disability. HL increases the risk of cognitive decline, mental illness, and depression, and leads to social isolation, unemployment/early retirement, loss of income and work discrimination. The pre-eminent management strategy for HL is the provision of Hearing Aids (HAs), although their use is often problematic, c ...
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 14

 TERMINÉ 

Female cancer prediction using cervical omics to individualise screening and prevention (FORECEE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions t ...
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 14

 TERMINÉ 

Accelerated market launch of MedEye, a plug-and-play medication safety solution (MedEye)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2019,

Medication errors occur daily and form a major burden to society. Medication errors often lead to adverse drug reactions, lengthened hospital stays, increased healthcare costs, and in the most severe cases, increased mortality. Medication errors pose a significant risk to the European population. It is estimated that 4,7 million Europeans are harmed by a medication error every year, which amounts ...
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 5

 TERMINÉ 

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways (EYE-RISK)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention ...
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 13

 TERMINÉ 

Novel Stromal Cell Therapy for Diabetic Kidney Disease (NEPHSTROM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Type 2 diabetes will affect >500 million adults by 2040 and its secondary complications will generate enormous socioeconomic costs - in particular, diabetic kidney disease (DKD), which is already the most common cause of chronic kidney disease. DKD is associated with greatly increased mortality and frequently progresses to end stage renal failure. Pharmacotherapy, dialysis and transplantation repr ...
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 12

 TERMINÉ 

Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap (ARISE)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2019,

65,000 aortic valve replacements (AVR) are performed in Europe each year to treat acquired and congenital aortic valve diseases. In affected patients, mortality without AVR is extremely high and 50 % die within 2 years. Current AVR options are, however, limited for young patients - especially female patients - and those unwilling to accept life-long medical anticoagulation with its inherent risks. ...
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 9

 TERMINÉ 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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 27

 TERMINÉ 

Personalised Decision Support for Heart Valve Disease (EurValve)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2019,

Valvular Heart Disease currently affects 2.5% of the population, but is overwhelmingly a disease of the elderly and consequently on the rise. It is dominated by two conditions, Aortic Stenosis and Mitral Regurgitation, both of which are associated with significant morbidity and mortality, yet which pose a truly demanding challenge for treatment optimisation. By combining multiple complex modelling ...
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 14

 TERMINÉ 

Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongl ...
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 12

 TERMINÉ 

Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
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 38

 TERMINÉ 

Teaching and Coaching Innovation & Entrepreneurship InnovaTively

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

The project builds on an existing community linked to ISPIM Society focused on innovation and entrepreneurship (I&E) – a theme of central interest in EU as a source of employment and growth. The consortium consists of industrial partners (Nokia Networks, Lufthansa, Torbay Hospital, AachenMuenchener, BMW, Lego) and academics who share a concern with the question:How do we improve on current I&E te ...
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 12

 TERMINÉ 

Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis (ADIPOA2)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Osteoarthritis (OA) is an incurable disease that has evaded pharmacological interference, biologic therapy or surgical intervention to prevent disease progression. Currently, OA is designated the 11th highest contributor (of 291 diseases) of global disability. In the absence of effective treatment options, cellular therapies using mesenchymal stem/stromal cells (MSCs) have emerged as potential can ...
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 20

 TERMINÉ 

Granollers on the move

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2018,

Institut Escola Municipal de Treball in Granollers (Catalonia) submits this mobility project in the field of VET, under the title Granollers on the move (acronym Granmove).The center, whose owner is the City Council of Granollers, starts with this projects its firm commitment to the internationalisation, and specifically in the VET field. This commitment has to do with the II Strategic Plan of the ...
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 5

 TERMINÉ 

I-MOVE+ Integrated Monitoring of Vaccines Effects in Europe: a platform to measure and compare effectiveness and impact of influenza and pneumococcal vaccines and vaccination strategies in the elderly (I-MOVE-plus)

Date du début: 1 mai 2015, Date de fin: 31 oct. 2018,

The I-MOVE+ Consortium includes European Union (EU) Public Health Institutes, SME and Universities. It aims at measuring and comparing the effectiveness (VE) and impact (VI) of influenza and Pneumococcal vaccines and vaccination strategies a in the elderly population in Europe. The goal is to develop a sustainable platform of primary care practices, hospitals and laboratory networks that share val ...
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 33

 TERMINÉ 

Labeling of Enalapril from Neonates up to Adolescents (LENA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Children are often treated as small adults—not as the special patients they are. Regulations exist to encourage the development of drugs and formulation for children. However, off-patent drugs are often administered to children without appropriate formulations or systematic investigations. Therefore, the paediatric use marketing authorisation (PUMA) has been designed.The EMA Paediatric Working Par ...
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 14

 TERMINÉ 

Dobutamine for NEOnatal CIRCulatory failure defined by novel biomarkers (NEO-CIRC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2018,

Dobutamine and adrenaline are widely used as second line therapy for systemic hypotension in infants. Dopamine is currently the most widely used first line drug. In neonates, sustained hypotension may, and impaired organ perfusion will, cause brain injury and poor neurodevelopmental outcomes. All three catecholamines are currently used off-label and have different modes of action which may result ...
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 20

 TERMINÉ 

Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors (REQUITE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million ...
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 15

 TERMINÉ 

Healthy Diversity

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Cultural differences do matter in the capacity to provide and access health services. Exploratory training we have run show that professionals meet challenges related to cultural differences regularly – reflecting different conceptions and norms related to the body, to birth, to illness, to death, to medicine etc. These challenges, when not addressed properly, can result in the refusal of the tr ...
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 7

 TERMINÉ 

Training staff in the use of the Arts for the Benefit of patients with LOng-term conditions

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Chronic diseases are a worldwide burden, causing 36 million deaths each year (World Health Organization, 2013). They are long-lasting conditions, which require regular treatment, administration, management and care, posing staggering socio-economic burdens on societies and health systems around the world. In this context, the use of arts for individuals suffering from long-term conditions can imp ...
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 8

 TERMINÉ 

Assistive Living Training and Skills

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Objectives of the Assistive Living Technology and Skills (ALTAS) project: The ALTAS project addresses the shortfall of assistive living technology (ALT) training courses for health and social care staff that will ultimately enable their clients and patients to benefit from smart solutions to live independently, self-care and improve their health and well-being. Key objectives are to: (1) develop a ...
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 9

 TERMINÉ 

Schulentwicklung-Qualitätssicherung im Fremdsprachenunterricht

Date du début: 4 juil. 2016, Date de fin: 3 juil. 2018,

Background of the project:Our school has been "Neue Mittelschule" for some years - the challenges for the teachers are really big, because the level of the pupils vary from very low to very high. in order to handle this situation - since January 2015 also refugee kids have been attending our school- new, modern, creative methods are essential.In the framework of the project "Schulqualität" our sch ...
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 1