5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Beta Cell Generation by Stem Cell-Derived Implants in Diabetes (BetaCellTherapy)
Date du début: 1 déc. 2015, Date de fin: 31 août 2020,
Despite improved treatment, diabetes remains a chronic disease with major health risks and heavy burden on patients and society. Serious forms are caused by depletion in pancreatic beta cells and associated loss in insulin’s homeostatic control throughout life. Their cure requires restoration of a metabolically adequate beta cell mass. Implants of beta cell grafts prepared from human pancreases ha ...
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8
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TERMINÉ
Chromatin and MetabolismChromatin-metabolism interactions as targets for healthy living (ChroMe)
Date du début: 1 mars 2016, Date de fin: 29 févr. 2020,
Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chrom ...
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12
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TERMINÉ
"Health and the Understanding of Metabolism, Aging and Nutrition" (HUMAN)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
"Recently intense research identified around 4,000 single nucleotide polymorphisms (SNPs) associated with human age related diseases such as metabolic disorders. Despite their highly significant association to pathology, the functional role of these genetic variants is, in most cases, yet to be elucidated. The evolutionary distance of most animal models from humans represents a major limitation fo ...
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17
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TERMINÉ
New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe (NU-AGE)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
"NU-AGE is a large multidisciplinary consortium (30 partners, from 16 EU countries) involving nutritionists, biogerontologists, immunologists and molecular biologists from the most prestigious institutions in Europe, 5 large food industries, 8 traditional food companies and 1 biotech SME, SPES GEIE and FooDrinkEurope, covering the SME Food Industrial Associations of 13 European countries and the ...
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35
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TERMINÉ
Control of mouse metabolism by circadian clock-coordinated mRNA translation (CIRCATRANS)
Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,
The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid, glucose and xenobiotic metabolism. Impairment of this rhythm has been show to lead to diverse pathologies including metabolic syndrome. At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level. We have now co ...
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