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TERMINÉ
Development of a late-onset-Alzheimer’s disease (LOAD) profile for accurate diagnosis and identification of potential therapeutic approaches (LOAD Profile)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that ...
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TERMINÉ
Identification of the protein interactome of the A2A-adenosine receptor (adenosine-receptor)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
The A2A-adenosine receptor is a Gs-coupled receptor, which has several unique structural and functional characteristics. Recently, the C-terminus of the receptor has been appreciated as a binding site for several “accessory” proteins, of which only half a dozen are established. It is clear that (i) this list cannot be exhaustive and (ii) that all these proteins cannot bind simultaneously to the re ...
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