Rechercher des projets européens

"There is now increasing evidence that specific nucleic acid structures modulate gene expression levels both at the transcriptional and at the translational level. In particular, G-quadruplex (G4) structures are attractive targets for anticancer strategies, since several studies showed that their stabilization by ligands caused proliferation arrest, telomere deprotection and changes in gene expres ...

Certain nucleic acids sequences can form unusual structures, like triplexes, G-quadruplexes and i-motif. Nowadays, several genetic diseases have proved to be mediated by the formation of non-B DNA structures at certain chromosomal locations. Therefore, it is very important to inversigate these unusual DNA structures, which may well be biologically relevant, at the molecular level. To study the fun ...