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TERMINÉ
Breaking the code of RNA sequence-structure-function relationships: New strategies and tools for modelling and engineering of RNA and RNA-protein complexes (RNA+P=123D)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
Ribonucleic acid (RNA) is a large class of macromolecules that plays a key role in the communication of biological information between DNA and proteins. RNAs have been also shown to perform enzymatic catalysis. Recently, numerous new RNAs have been identified and shown to perform essential regulatory roles in cells.As with proteins, the function of RNA depends on its structure, which in turn is en ...
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TERMINÉ
Engineered Sequence-Specific RNases: New Reagents for RNA biotechnology (ERNASES)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2013,
The basic idea to be taken to the proof of concept is creation of novel molecular biology tools, ie. enzymes acting on DNA/RNA hybrids and dsRNA that are able to cut the RNA strand(s) in a site specific manner. We have already created prototypic proteins of those two classes of ‘RNA restriction enzymes’ and performed initial steps towards commercialization of the project. We are applying for fundi ...
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