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36 projets européens trouvés

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 EN COURS 
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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 44

 TERMINÉ 

Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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 3

 TERMINÉ 
How lipids are regulated on a global scale during vascular inflammation is not known. Thus, a major challenge exists to describe and catalog the total lipidome, in particular enabling the identification of new biologically active lipids, and description of changes. This is analogous to ‘omics’ of DNA, RNA and protein, but instead describing diversity of lipids in tissue samples. Importantly, thi ...
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 2

 TERMINÉ 
IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and (II) the focused application of this pipeline to derive clinically significant mechanistic taxonomies of neurodegenerativ ...
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 20

 TERMINÉ 
DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Pluripotent stem cell resources for mesodermal medicine (PLURIMES)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progeni ...
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 12

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Improving Children's Auditory Rehabilitation (iCARE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Improving Children’s Auditory REhabilitation (iCARE)Communication through language is vital to develop and maintain everything around us. By 15 years of age, about 5 out of 1000 children suffer from a moderate, severe or profound hearing impairment that can potentially affect communication, learning, psychosocial development and academic achievement if not appropriately handled.The EU promotes the ...
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 9

 TERMINÉ 

Developing an European American NGS Network (DEANN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

The DEANN project is a network formation initiative that involves six research institutions and universities from four EU countries and equivalently, six research entities from four Latin American countries. The overall goal is to strengthen research partnership among the participants by developing a shared scientific knowhow in the field of Next Generation Sequencing data analysis. More specific ...
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 7

 TERMINÉ 
Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time func ...
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 12

 TERMINÉ 

"Training in neurodegeneration, therapeutics intervention and neurorepair" (TINTIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"Dopamine neurons play a central role in major illnesses, such as anxiety and mood disorders, schizophrenia, autism-spectrum disorders, Parkinson’s disease, epilepsy, and dementia. A multidisciplinary approach must be taken by European researchers to discover the molecular basis of dopamine neurodegeneration and how new technologies will lead to repair and regeneration of neuronal systems in the b ...
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 8

 TERMINÉ 
TRANSLINK is a project devoted to assessing the mid-to long-term risk factors and improve the outcome of animal (bovine/porcine)-derived Bioprosthetic Heart Valve (BHV) implants. 300,000 patients/year benefit from BHV, a major healthcare problem (second most frequent cardiac surgery). BHV clinical outcome suffers from late dysfunctions restricting their application to older recipients. Based on a ...
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 14

 TERMINÉ 

Global Research in Paediatrics (GRiP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

 TERMINÉ 

Co-morbidity in relation to Aids (COBRA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, de ...
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 12

 TERMINÉ 
Gait and postural control impairments, and falls are ubiquitous among the elderly, and lead to enormous personal, occupational and health care burden. Especially patients with PD are severely affected by the progressive deterioration of these gait and postural control mechanisms. Elucidating mechanisms of age- and disease-related motor control impairments and devising focussed treatment strategies ...
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 9

 TERMINÉ 

European Bank for induced pluripotent Stem Cells (EBISC)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 TERMINÉ 
Substantial evidence supports the therapeutic potential of ex vivo gene therapy based on Hematopoietic Stem Cell (HSC) or T lymphocytes to treat inherited diseases or cancer. Yet, the intrinsic limitations of current gene replacement approaches based on semi-randomly integrating vectors, and the occurrence in some clinical trials of severe adverse events related to gene transfer, prevent safe depl ...
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 5

 TERMINÉ 
"In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected ...
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 12

 TERMINÉ 

The Human Brain Project (HBP)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the ...
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 116

 TERMINÉ 

Drug Disease Model Resources (DDMORE)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capa ...
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 28

 TERMINÉ 

Microcircuits for behavioral modulation of sensory cortex (SENSMOD)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

An outstanding question in Neuroscience is to understand how the brain integrates sensory and non-sensory information. Strikingly, this integration takes place even in the primary sensory cortices, where sensory processing is strongly modulated by non-sensory context. For example, in primary visual cortex (V1), responses depend not only on visual stimulation, but also on locomotion (Niell and Stry ...
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 1

 TERMINÉ 
One of the major challenges of modern molecular biology is to understand how healthy cells transform into malignant, proliferating cells leading to diseases such as cancer and which proteins trigger these aberrant signalling cascades. The ErbB family of receptor tyrosine kinases (RTKs) are pivotal mediators of the signalling network that transmit extracellular signals into the cell and control cel ...
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 1

 TERMINÉ 

Targeting Glioblastoma Signalling (GBMTARGET)

Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,

This project will establish a computational strategy which exploits polypharmacology to identify drug targets in biological systems implicated in cancer. The value of our polyphamacology platform will be tested by application to glioblastoma multiforme, a deadly brain cancer. The aim will be to identify multiple targets in protein networks linked to glioblastoma to thereby enable repositioning of ...
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 1

 TERMINÉ 

Spatial Cognition (SpaceCog)

Date du début: 1 mars 2013, Date de fin: 29 févr. 2016,

Humanoid robots will become important machines to support mankind if they develop similar capabilities as humans have. One of those capabilities is to orient in space and to extract the relevant information from its environment. A common approach has been to build a spatiotopic map of the external world, so called an internal world model. However, since the sensors, such as the eyes (cameras) are ...
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 6

 TERMINÉ 

Cutaneous and Mucosal HIV Vaccination (CUT'HIVAC)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

Despite significant effort over the past decade to design and implement new vaccines strategies against HIV, no one has met its promise to prevent infection and/or to reduce viral load until reaching eradication of the HIV reservoir. To reach this goal, a translational research is critical to propose innovative approaches for an HIV vaccine enhancing broadly cross-reactive mucosal, humoral and cel ...
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 18

 TERMINÉ 
Antisocial behaviour is a substantial problem in Europe: detrimental to victims, the youth, families and society as a whole. Among promising research avenues are the use of genetically informative longitudinal studies, as well as research designs aimed to determine which predictors of antisocial behaviour are causative. Using such innovative designs, my primary purpose is to provide a better under ...
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 1

 TERMINÉ 
Inflammation of the lung is central to the pathogenesis of most respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), cystic fibrosis (CF) and pneumonia. Leukocytes traffic through normal lung for immune surveillance; but these numbers increase in response to toxins or pathogens and can be overwhelming. Leukocytes can exit from the lung inte ...
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 1

 TERMINÉ 

SEROTONERGIC REGULATION OF SLEEP RELATED NEURAL CIRCUIT (SerotoninSleep)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

Summary: The appropriate regulation of sleep and wakefulness is a fundamental biological process that impacts human health, cognitive performance, and quality of life. However, the neural mechanisms regulating sleep/wake behavior and its associated circuits in the brain are largely unknown. Recent studies have illustrated the role of hypocretin/orexin (Hcrt) in sleep regulation, but the mechanis ...
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 1

 TERMINÉ 
Synaptic connectivity within and between neurons in brain networks determines the flow of information, how signals are combined and how they are transformed. However, our understanding of information processing in brain networks remains poor. The cerebellar cortex is an attractive model to study network processing because it consist of relatively few, well defined cell types and a relatively simpl ...
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 1

 TERMINÉ 

Protein-RNA networks ALS (PRANA)

Date du début: 1 août 2013, Date de fin: 31 juil. 2015,

Interactions between proteins and RNAs regulate processing, localization, decay and translational regulation of mRNAs. Recently, it was revealed that the number of putative RBPs in mammalian cells is about three times larger than appreciated. However, the exposed interaction network was inspected only in a single given state; furthermore the functional gene expression mechanism is yet unknown. In ...
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 1

 TERMINÉ 
How do neurons in the brain process information from the outside world? Although generations of neuroscientists have focused on this question, it remains a mystery. The crux of the problem is to understand the neural code, or the rubric by which the brain converts information about the world into brain activity. Primary sensory cortices, where much of the transformation of information takes pla ...
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 1

 TERMINÉ 

Signalling mechanisms of the class II isoforms of PI 3-kinase (PI3K-C2-SIG)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

"PI 3-kinases (PI3Ks) generate intracellular lipid second messengers in signal transduction and membrane trafficking pathways. PI3Ks are implicated in cancer, inflammation and autoimmunity, and represent attractive drug targets. Mammalian PI3K isoforms are divided into class I, II and III PI3Ks. While the class I PI3Ks have been extensively studied and targeted in drug development, the other PI3Ks ...
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 2

 TERMINÉ 
"Coordinated migration of cells is an important process in development and physiology. Collective migration has been extensively studied in tightly connected cell sheets, or epithelia, with recent studies reporting forces in epithelial collective migration. Although a physical and functional connection between the cells throughout the whole process has been thought necessary for collective migrati ...
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 1

 TERMINÉ 
"Background: Schizophrenia and bipolar disorder are severe mental illnesses which cause high rates of disability, social and economic costs. Although there is compelling evidence of a genetic contribution to psychosis and we know deficits in neuronal connectivity are a key factor, the pathophysiology and aetiology of the disease remain poorly understood. Aims: (i) To identify biomarkers of neural ...
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 1

 TERMINÉ 

Global Alliance for Chronic Diseases (GACD)

Date du début: 1 janv. 2013, Date de fin: 31 mars 2014,

"The Global Alliance for Chronic Diseases (GACD) brings together leading health research funding agencies of key countries (currently USA, Canada, UK, Australia, China, India and South Africa) to coordinate research activities addressing on a global scale the prevention and treatment of chronic, non-communicable diseases such as cardiovascular diseases, diabetes, respiratory diseases, cancer and m ...
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 1

 TERMINÉ 
An important question of modern neurobiology is how neurons regulate synaptic function in response to excitation. In particular, the roles of alternative pre-mRNA splicing and mRNA translation regulation in this response are poorly understood. We will study the RNA-binding proteins (RBPs) that control these post-transcriptional changes using a UV crosslinking-based purification method (CLIP) and u ...
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 3