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 EN COURS 
Phenotypic variation arises from the heritable acquisition of cell-type specific gene-expression programs. Key in understanding cellular specification is to elucidate the epigenetic mechanism that underlies transcriptional heterogeneity. Thus a central question in biology is how cell-to-cell variability in the epigenome contributes to the emergence of phenotypic differences. However, current tech ...
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 1

 EN COURS 
Gene expression is a highly dynamic and inherently variable process. Yet, it needs to be tightly regulated, especially during the cell cycle, when continuous large-scale changes occur to the proteome. Even small deviations in the expression levels of a single protein in individual cells can de-regulate cell cycle entry and promote tumorigenesis. Here, I will develop new technology to study gene ex ...
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 1

 EN COURS 

Fuel and chemicals from lignin through enzymatic and chemical conversion (FALCON)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The transition to a biobased economy puts strong challenges on researchers and industry to develop sustainable processes. 2G biofuel plants use waste streams as substrates, but themselves generate a new waste stream of lignin-rich sludge that is left after saccharification of the carbohydrates. This waste stream is expected to exponentially increase with an increasing number of 2G bioethanol plant ...
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 9

 EN COURS 
Experimentation in mesocosms is arguably the single most powerful approach to obtain a mechanistic quantitative understanding of ecosystem-level impacts of stressors in complex systems, especially when embedded in long-term observations, theoretical models and experiments conducted at other scales. AQUACOSM builds on an established European network of mesocosm research infrastructures (RI), the FP ...
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 23

 EN COURS 

ACCELERATing Europe's Leading Research Infrastructures (ACCELERATE)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

CERIC-ERIC (CERIC) is a distributed research infrastructure for fundamental and applied research on novel materials and biomaterials. The RI has been in operation for 2 years and provides open access to a broad range of instruments and expertise across research communities, in order to support the research community world-wide in tackling the most challenging problems of materials research. The A ...
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 8

 EN COURS 
Environmental perturbations to lakes and reservoirs occur largely as episodic climatic events. These range from relatively short mixing events to storms and heat waves. While the driving events occur along a continuum of frequency and magnitude, however, their effect is generally longer lasting than the events themselves. In addition, the more extreme weather events are now becoming increasingly ...
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 8

 EN COURS 

INtestinal Tissue ENgineering Solution (INTENS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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 9

 EN COURS 
We pioneered the essential role of Wnt signals in adult stem cells, i.e. in intestinal crypts. We also found that loss of the APC gene activates the Wnt pathway and causes colorectal cancer (CRC). We then identified a Wnt target gene, Lgr5, which allowed us to define the crypt stem cells. In a previous ERC grant based on these findings, we identified novel Lgr5 stem cells in multiple organs, and d ...
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 1

 EN COURS 
Major depression is among the most burdening health hazards. Its prevalence is 1-3%, an additional 8-16% have clinically significant symptoms, and prognosis is poor. Unfortunately, less than 20% of the cases are detected and treatment effectiveness is moderate. The Global Consortium for Depression Prevention stresses that our best chance to combat the global burden of depression is provide prevent ...
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 1

 TERMINÉ 
The Industrial Revolution is one of the most important events in human history: within a century, some countries multiplied their per capita income while others stagnated, exacerbating international inequality. Reducing this enduring inequality through industrial development has been a crucial policy goal; however, as no precise understanding of industrial development exists, no consistent interna ...
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 1

 TERMINÉ 

Tumor cell death supports recurrence of cancer (Cancer-Recurrence)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Introduction: Current anti-cancer treatments are often inefficient, while many patients initially benefit from anti-cancer drugs eventually experience relapse of resistant tumors throughout the body. Current clinical strategies mainly aim at inducing tumor cell death, but this induction may have unintentional and unwanted side effects on surviving tumor cells.Preliminary data: We show that after c ...
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 1

 TERMINÉ 
The basal ganglia consist of a set of neuroanatomical structures that participate in the representation and execution of action sequences. Dopamine neurotransmission in the striatum, the main input nucleus of the basal ganglia, is a fundamental mechanism involved in learning and regulation of such actions. The striatum has multiple functional units, where the limbic striatum is thought to mediate ...
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 2

 TERMINÉ 
European aquaculture production provides direct employment to 80,000 people and a 3-billion € annual turnover. Parasites cause severe disease outbreaks and high economic losses in finfish aquaculture. The overarching goal of ParaFishControl is to increase the sustainability and competitiveness of European Aquaculture by improving understanding of fish-parasite interactions and by developing innova ...
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 31

 TERMINÉ 
European societies face rapid social changes, challenges and benefits, which can be studied with traditional tools of analysis, but with serious limitations. This rapid transformation covers changes in family forms, fertility, the decline of mortality and increase of longevity, and periods of economic and social instability. Owing to population ageing across Europe, countries are now the experienc ...
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 10

 TERMINÉ 

Generations and Gender Programme: Evaluate, Plan, Initiate (GGP-EPI)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

The Generations and Gender Programme (GGP) provides high quality cross-national, longitudinal data for the study of population change. The data provided by the GGP have been used by more than 3,000 researchers worldwide and have led to over 500 peer-reviewed journal articles. The data have provided insights into some of the most pressing societal challenges such as care for older persons, female e ...
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 9

 TERMINÉ 
All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As ...
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 11

 TERMINÉ 

From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts (OPATHY)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

OPATHY is an innovative translational research training network that will explore the potential of omics technologies, including genomics, transcriptomics and proteomics, to study the interactions of yeasts that cause disease to humans (e.g. Candida and Cryptococcus sp.) with their host, and to develop new diagnostic tools to monitor yeast infections in the clinic. Today, these infections are poor ...
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 10

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

 TERMINÉ 

Synergies for Europe's Research Infrastructures in the Social Sciences (SERISS)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2019,

Europe is facing huge socio-economic challenges: an economic crisis with a young generation in search of jobs, population ageing potentially straining inclusion and innovation of our societies, climate change with its pressures to redesign energy, transport and housing patterns, just to name some of the most urgent “Grand Challenges”. SERISS brings together three research infrastructures in the so ...
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 6

 TERMINÉ 
PARTHENOS aims at strengthening the cohesion of research in the broad sector of Linguistic Studies, Humanities, Cultural Heritage, History, Archaeology and related fields through a thematic cluster of European Research Infrastructures, integrating initiatives, e-infrastructures and other world-class infrastructures, and building bridges between different, although tightly, interrelated fields. PAR ...
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 19

 TERMINÉ 

Cortical algorithms for perceptual grouping (Cortic_al_gorithms)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Why do we perceive objects? Visual perception starts with localized filters that subdivide the image into fragments that undergo separate analyses. Our visual system has to reconstruct the objects that surround us. It has to bind image fragments of the same object and to segregate them from other objects and the background. The standard view in psychology is that perceptual grouping is achieved by ...
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 1

 TERMINÉ 

European Holocaust Research Infrastructure (EHRI)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

The European Holocaust Research Infrastructure (EHRI) project seeks to transform archival research on the Holocaust. The vision of EHRI is to integrate the data, services and expertise of existing Holocaust infrastructures on an unprecedented scale. It will allow researchers from across the globe transnational and virtual access to the integrated infrastructure, and provide them with innovative di ...
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 25

 TERMINÉ 

MicroRNA function in cardiac and metabolic disease (MICARUS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

"Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Despite numerous treatment options the prevalence of cardiovascular indications continues to increase, underscoring the need for new therapeutic strategies.In recent years, prominent roles of microRNAs (miRNAs) have been uncovered in a variety of cardiovascular disorders. miRNAs are short, single stranded RNAs that ...
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 1

 TERMINÉ 

Advancing the European Multilingual Experience (ATHEME)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

"The project Advancing The European Multilingual Experience (AThEME) takes an integrated approach towards the study of multilingualism in Europe by incorporating and combining linguistic, cognitive and sociological perspectives; by studying multilingualism in Europe at three different levels of societal magnitude, viz. the individual multilingual citizen, the multilingual group, and the multilingu ...
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 18

 TERMINÉ 

The European Open Science Cloud for Research Pilot Project. (EOSCpilot)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,

The EOSCpilot project will support the first phase in the development of the European Open Science Cloud (EOSC) as described in the EC Communication on European Cloud Initiatives [2016]. • It will establish the governance framework for the EOSC and contribute to the development of European open science policy and best practice; • It will develop a number of pilots that integrate service ...
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 39

 TERMINÉ 
Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multipl ...
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 11

 TERMINÉ 
The world is seasonal and organisms’ adjustment of their seasonal timing to this environmental variation is crucial for their fitness. Climate change is strongly impacting seasonal timing which makes a better understanding of the potential for micro-evolution of timing in natural populations essential. As any phenotypic change ultimately involves changes in the physiological mechanism underlying t ...
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 1

 TERMINÉ 
The proposed project aims at the intensification of cooperations between research infrastructure organisations in German, the Netherlands and Thailand that are recognised internationally as strongholds in mycological, biotechnological and microbiological research. The cooperation is intended to explore the mycological and microbiological biodiversity of Europe and Southeast Asia, in particular wit ...
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 2

 TERMINÉ 

A novel approach for modeling development of breast cancer (BRCANCER)

Date du début: 4 janv. 2016, Date de fin: 3 juil. 2018,

Inheriting one mutant copy of the BRCA1 or BRCA2 gene is associated with a significant increased risk for developing aggressive and difficult to treat breast cancer, the most common cancer type in women worldwide. Despite previous efforts to recapitulate tumorigenesis with the use of mouse models and cancer cell lines, the exact mechanisms that underlie BRCA1 or BRCA2-dependent tumor development r ...
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 1

 TERMINÉ 

Open Access Infrastructure for Research in Europe 2020 (OpenAIRE2020)

Date du début: 1 janv. 2015, Date de fin: 30 juin 2018,

OpenAIRE2020 represents a pivotal phase in the long-term effort to implement and strengthen the impact of the Open Access (OA) policies of the European Commission (EC), building on the achievements of the OpenAIRE projects. OpenAIRE2020 will expand and leverage its focus from (1) the agents and resources of scholarly communication to workflows and processes, (2) from publications to data, software ...
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 50

 TERMINÉ 
"In an era of worldwide increasing inequalities, key social science issues about the production and reproduction of social inequality gain renewed attention. One central issue is the role played by demographic events and trajectories in producing and reproducing inequalities. This proposal examines this issue by studying the relationships between the experience of childhood social disadvantage, de ...
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 1

 TERMINÉ 
"Climate warming promotes intra-continental range shifts of plants, animals and microbes from lower to higher latitudes and altitudes. Plants may shift their ranges independent of their co-evolved aboveground and belowground biota, however little is known about how these communities re-assemble in the new range and how that process influences community dynamics and ecosystem functioning. Thus far, ...
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 1

 TERMINÉ 
"In many European countries at least 20% of young men exhibit sperm parameters below the lower WHO reference level and this will affect their fertility. Male infertility has a dramatic impact on the individual and couple’s psychological and social well-being and results in significant healthcare costs. Currently male patients that do not produce sperm have no therapeutic options to father children ...
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 7

 TERMINÉ 

Knowledge Complexity (K-PLEX)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2018,

One of the major terminological forces driving ICT development today is that of ‘big data.’ While the phrase may sound inclusive and integrative, in fact, ‘big data’ approaches are highly selective, excluding any input that cannot be effectively structured, represented, or, indeed, digitised. Data of this messy, dirty sort is precisely the kind that humanities and cultural researchers deal with ...
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 4

 TERMINÉ 
In the adult neurogenic niches, neural stem cells (NSCs) generate neurons throughout life. During aging, the number of newborn neurons is clearly reduced, although it is still very debated what specifically happens to the NSCs: do they die, increase their quiescence or change their fate? It is emerging that NSCs are heterogeneous, with different subtypes, in particular quiescent and active NSCs, r ...
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 1

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

European Consortium for Communicating Stem Cell Research (EuroStemCell)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2018,

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Inf ...
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 32

 TERMINÉ 

EUDAT2020

Date du début: 1 mars 2015, Date de fin: 28 févr. 2018,

EUDAT2020 brings together a unique consortium of e-infrastructure providers, research infrastructure operators, and researchers from a wide range of scientific disciplines under several of the ESFRI themes, working together to address the new data challenge. In most research communities, there is a growing awareness that the “rising tide of data” will require new approaches to data management and ...
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 36

 TERMINÉ 
The ability to understand and predict the actions of others is critical for human social interaction but how the brain accomplishes this function is still poorly understood. This project will explore this fundamental question using an original and innovative approach, by studying how we anticipate the actions of others before they even start to act. The final aim will be to develop a model that in ...
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 1

 TERMINÉ 

Humanities at Scale: Evolving the DARIAH-ERIC (HaS-DARIAH)

Date du début: 1 sept. 2015, Date de fin: 31 déc. 2017,

The ‘Humanities at Scale’ project will further the DARIAH ERIC’s aim to integrate digitally enabled research in the arts and humanities in Europe and beyond and to operate a platform to enable trans-national arts and humanities research. The project will help DARIAH sustain existing knowledge in digital arts and humanities in Europe and enable new one. DARIAH connects various hubs of excellence in ...
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 5