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 TERMINÉ 

Mitochondrial regulation of structural and functional plasticity within adult neurogenic circuits (MITOPLASTICITY)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits. Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. ...
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 2

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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 13

 TERMINÉ 

Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (CarBon)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic p ...
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 9

 TERMINÉ 

Investigating the impact of meditation training on mental health and wellbeing in the ageing population (MEDIT-AGEING)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potent ...
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 12

 TERMINÉ 

Antibody-Mediated Therapy of HIV-1 Infection (HIV1ABTHERAPY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 repl ...
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 2

 TERMINÉ 

European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry (EN_ACTI2NG)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors an ...
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 11

 TERMINÉ 

Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES) (BRIDGES)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast cancer affects more than 360,000 women per year in the EU and causes more than 90,000 deaths. Identification of women at high risk of the disease can lead to disease prevention through intensive screening, chemoprevention or prophylactic surgery. Breast cancer risk is determined by a combination of genetic and lifestyle risk factors. The advent of next generation sequencing has opened up th ...
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 20

 TERMINÉ 

A systematic characterization of human regulatory architectures and their determinants of regulatory activity (SCORA)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity.Genome-wide chromatin assays have provided insight into the properties and co ...
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 4

 TERMINÉ 

Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)

Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,

Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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 23

 TERMINÉ 

Combatting Bacterial Resistance in Europe (COMBACTE-NET)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2019,

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies. The estimated costs of ARB are aro ...
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 38

 TERMINÉ 

Advanced Regenerative and REStorative Therapies to combat corneal BLINDNESS (ARREST BLINDNESS)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Over 30 million Europeans are blind or visually impaired, leading to reduced quality of life and a tremendous loss of productivity in society. Corneal blindness is the second largest cause of blindness globally and while treatable, millions remain unnecessarily blind due to issues of access to transplantable tissue, lack of standardized treatments, and the lag in translating new regenerative medic ...
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 14

 TERMINÉ 

Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases (PRECISESADS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therape ...
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 30

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Systems biology for the functional validation of genetic determinants of skeletal diseases (SYBIL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth char ...
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 19

 TERMINÉ 

Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography (INSCAPE)

Date du début: 15 mai 2015, Date de fin: 14 mai 2018,

Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare du ...
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 2

 TERMINÉ 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

Neovascular glaucoma (NVG) is a very aggressive and rare type of glaucoma: yet, it contributes disproportionately to blindness from all eye diseases. NVG is also the second most common cause for the removal of the eye-ball across all eye diseases, usually because of intractable pain. The major cause of NVG is Ischaemic Central Retinal Vein Occlusion (CRVO) leading to neovascularisation, obstructio ...
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 9

 TERMINÉ 

Mitochondrial unfolded protein response and the role in ageing (MITOUPR)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Cells use sensor pathways compartmentalized in subcellular organelles to recognize stress conditions, including aberrant protein folding, and in response activate gene expression programs aimed at maintaining cell survival and restoring homeostasis. Fine-tuning of the protein-folding environment in organelles like mitochondria is important for adaptive homeostasis and may participate in developme ...
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 2

 TERMINÉ 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

La mobilité Erasmus+ -"Défi et chance pour les acteurs en formation professionnelle dans le domaine des professions de santé -"

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

he apprentices are going to conduct an internship in a hospital or care institution abroad. They will be in possession of a booklet or portfolio which will clearly explain the level and type of training as well as the specific objectives of the course. The booklet will also include an evaluation form of the professional skills, which the apprentice has to work with during the probationary period. ...
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 9

 TERMINÉ 

Genome Stability Mechanisms in Aging (GENSTAGE)

Date du début: 1 juil. 2011, Date de fin: 28 févr. 2017,

"Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant experimental system to study the role of genome stability in aging. Using the NER system we recently uncovered a novel link ...
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 2

 TERMINÉ 

European Bank for induced pluripotent Stem Cells (EBISC)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 TERMINÉ 

EUROPEAN FORENSIC GENETICS Network of Excellence (EUROFORGEN-NOE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

The EUROFORGEN-NoE proposal aims to develop a network of excellence for the creation of a European Virtual Centre of Forensic Genetic Research. Forensic genetics is a highly innovative field of applied science with a strong impact on the security of citizens. However, the genetic methods to identify offenders as well as the creation of national DNA databases have caused concerns to the possible vi ...
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 19

 TERMINÉ 

Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation (IMPACT)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in ...
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 10

 TERMINÉ 

Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health (Full4Health)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

Full4Health is a multidisciplinary European collaboration of internationally renowned laboratories investigating the mechanisms of hunger, satiety and feeding behaviour, effects of dietary components and food structure on these processes, and their possible exploitation in addressing obesity, chronic disease and under-nutrition. The proposal integrates investigation of both human volunteers (dieta ...
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 16

 TERMINÉ 

Optimisation of treatment with off-patent antimicrobial agents of ventilator-associated pneumonia (VAP) (MagicBullet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Background. Ventilator-associated pneumonia (VAP) is one of the most common and severe hospital-adquired infections, and multidrugresistant gram-negative bacilli (MDR-GNB) constitute the main etiology in many countries. Inappropriate empiric antimicrobial treatment is associated with increased mortality. In this context, the empirical treatment of choice for VAP is unknown. Colistin, and “old” dru ...
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 11

 TERMINÉ 

Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems (DETECTIVE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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 15

 TERMINÉ 

Systems Biology of Stem Cells and Reprogramming (SyBoSS)

Date du début: 1 juin 2010, Date de fin: 30 nov. 2015,

Stem cells are central to emerging concepts in health, medicine and therapy. The realization that specific cell reservoirs retain multipotency for tissue establishment and replenishment has implications for both the emerging field of regenerative therapy and the long standing problems of cancer, ageing and degenerative diseases. Recently the prospects for regenerative therapy have been boosted by ...
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 11

 TERMINÉ 

La mobilité Erasmus Plus - Un défi pour les jeunes en formation professionnelle du domaine des professions de santé - Formation de l'aide-soignant et de l'infirmier responsable de soins généraux.

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2015,

The apprentices are going to conduct an internship in a hospital or care institution abroad. They will be in possession of a booklet or portfolio which will clearly explain the level and type of training as well as the specific objectives of the course. The booklet will also include an evaluation form of the professional skills, which the apprentice has to work with during the probationary period. ...
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 7

 TERMINÉ 

European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interaction ...
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 27

 TERMINÉ 

Development of a novel FGL therapy and translational tests for regenerative treatment of neurological disorders (NEUROFGL)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

Neurodegenerative disorders such as, Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), stroke, Traumatic Brain Injury (TBI) and chronic stress create a major economic burden to society and a substantial reduction in quality of life for patients and families. The development of neuroregenerative therapies is notoriously difficult and requires significant investment. NeuroFGL will contribut ...
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 7

 TERMINÉ 

Data Infrastructure for Chemical Safety (diXa)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry w ...
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 7

 TERMINÉ 

European Communication on Research Awareness Needs (ECRAN)

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

"The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with me ...
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 10

 TERMINÉ 

A IAPP on the Role of NCAM in Stem Cell Differentiation (STEMCAM)

Date du début: 1 sept. 2010, Date de fin: 31 août 2014,

The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMC ...
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 6

 TERMINÉ 

Determining (epi)genetic therapeutic signatures for improving lung cancer prognosis (CURELUNG)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

"Lung cancer (LC) is still the most lethal type of cancer worldwide. The extremely poor prognosis for LC patients is partly due to the lack of effective therapies. At present, most patients with pulmonary carcinomas are treated with chemotherapy. This essentially consists of classic cytotoxic drugs which only improve survival in small cohorts in few cases. In spite of the rapidly growing understan ...
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 11

 TERMINÉ 

Host and viral factors in acute hepatitis C (HEPACUTE)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2014,

Chronic hepatitis C is one of the most common chronic viral infections of humans and a major cause of chronic liver disease, cirrhosis and liver cancer. Still about 4 million new infections occur world-wide each year with 50-85% of patients progressing to chronic hepatitis C. Currently there is no marker to predict spontaneous viral clearance and to guide treatment decisions.The major objectives o ...
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 17

 TERMINÉ 

Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

 TERMINÉ 

European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
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 10

 TERMINÉ 

Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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 16