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 TERMINÉ 

DIabetes REsearCh on patient sTratification (DIRECT)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2019,

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.There is heterogeneity in who develops diabetes, the rate at which th ...
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 27

 TERMINÉ 

"Proposal to assess an innovative Immunotherapy, based on a thioredox peptide antigen, in a Phase I Trial for Type-1 Diabetes" (EXALT)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Type-1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are gradually destroyed by autoreactive T-cells recognising autoantigens (Auto-Ag) such as GAD65 and insulin. ImCyse, a small SME, has developed a new technology based on short synthetic peptides flanked with a thioredox motif, which silence the pathogenic immune response against several auto-Ag through activation of one a ...
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 7

 TERMINÉ 

Wheat and barley Legacy for Breeding Improvement (WHEALBI)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

WHEALBI will combine genomics, genetics and agronomy to improve European wheat and barley production in competitive and sustainable cropping systems. Germplasm representing the species diversity will be selected and characterised in unprecedented detail by next-generation-sequencing. Life history and adaptive traits will be evaluated in both transnational field experiments and a state-of-the-art p ...
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 20

 TERMINÉ 

Multi-dimensional omics approach to stratification of patients with low back pain (PAIN-OMICS)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

"Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capital ...
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 11

 TERMINÉ 

Phytoremediation driven energy crops production on heavy metal degraded areas as local energy carrier (Phyto2Energy)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

The scientific and technological (S&T) goal of the project is to develop and validate an innovative approach combining phytoremediation and production of biomass on heavy metal contaminated (HMC) areas which could be used as local energy carrier. The S&T objectives of the project are as follows: Objective1) selection of optimal plant species suitable for phytoremediation driven energy crops produc ...
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 6

 TERMINÉ 

Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation (MagnetoGenetics)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms.Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetrat ...
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 2

 TERMINÉ 

Identification and validation of novel pharmaceutical drug targets for cardiovascular disease (CARTARDIS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"Cardiovascular disease (CVD) is one of the major diseases in Europe and the Western world, killing over 2 million people per year in Europe alone and is the foremost cause of premature mortality and disability-adjusted life years, representing an annual economic cost of ∼€ 192 billion in direct and indirect healthcare expenses. The available therapies are insufficient to fulfill the need. The int ...
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 13

 TERMINÉ 

Organic Bioelectronics (ORGBIO)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Organic Bioelectonics is a new discipline which holds promise to shape, direct, and change future medical treatments in a revolutionary manner over the next decades. At the moment Europe has a unique leading position in this area, being almost all the world-leading groups in this field located in Europe and constituting the core of this international training network. However, realizing the promis ...
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 15

 TERMINÉ 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

Specificity of Rc3h1/2 proteins in post-transcriptional control of immunity and autoimmune disease (RC3H1/2-SPECIFICITY)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,

We are constantly protected by our adaptive immune system. Its functioning requires precise control of gene expression in lymphocytes, since deregulation can cause autoimmune diseases (affecting ~5% of our population) as well as allergic reactions (~9-16%, with increasing incidence). Post-transcriptional control of gene expression is crucial in many immune decisions, however the determinants of sp ...
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 2

 TERMINÉ 

European-study on Quantifying Utility of Investment in Protection from Tobacco (EQUIPT)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Tobacco smoking costs the EU an estimated 98 to 130 billion Euros each year – just above 1% of the EU Gross Domestic Product in 2000. A large, robust and consistent evidence base indicates that coordinated, high impact and comprehensive approaches are the most effective way to reduce smoking initiation, prevalence and intensity. Despite this, policy makers and public health procurers often lack th ...
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 11

 TERMINÉ 

European Medicines Research Training Network (EMTRAIN)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2016,

EMTRAIN is an essential element for the success of the IMI Education & Training (E&T) Call Topics in Europe (current and future). It will establish a pan-European platform of excellence for education and training covering the whole life-cycle of medicines from basic research through clinical development to pharmaco-vigilance. It will underpin the successful delivery of the current and future IMI-f ...
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 32

 TERMINÉ 

OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
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 25

 TERMINÉ 

Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)

Date du début: 1 mars 2011, Date de fin: 30 juin 2016,

The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
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 40

 TERMINÉ 

Priming epithelial cell activation to regenerate the lung (PEARL)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

Chronic obstructive pulmonary disease (COPD), a global health problem, will be the third leading cause of death by 2020. No effective therapy exists for COPD, which is characterized by a progressive loss of lung tissue, in particular functional alveolar epithelium, due to the inability of the lung to regenerate. Thus, regeneration of functional lung tissue would be a tremendous step forward, which ...
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 1

 TERMINÉ 

Modelling latent causes in molecular networks (LATENTCAUSES)

Date du début: 1 janv. 2011, Date de fin: 31 mars 2016,

In systems biology, we aim at deriving gene-regulatory or signaling models based on multivariate readouts, thereby generating predictions for novel experiments. However any model only approximates reality, leaving out details or other types of regulation. Here I ask why a given model fails to predict a set of observations with acceptable accuracy and how to refine the model using this experimental ...
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 1

 TERMINÉ 

Studies on a cohort of Serbian children exposed to x-irradiation to determine the contribution of the non-coding genome to susceptibility at low doses (DARK.RISK)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2016,

"The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be use ...
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 5

 TERMINÉ 

Low Dose Research towards Multidisciplinary Integration (DOREMI)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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 39

 TERMINÉ 

SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2015,

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as we ...
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 27

 TERMINÉ 

Uncovering the mechanisms of inflammation induced liver tissue destruction and carcinogenesis (LIVERCANCERMECHANISM)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2015,

Hepatocellular carcinoma (HCC) is caused by chronic hepatitis and is the third most common cause of cancer-related death worldwide, with a rising incidence in first world countries. To date no effective therapies other than liver transplantation are available for this disease.Previous studies have provided evidence that inflammatory signalling pathways (e.g. the NF-b pathway) are crucial modulato ...
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 1

 TERMINÉ 

Deep Tissue Optoacoustic Imaging for Tracking of Dynamic Molecular and Functional Events (DYNAMIT)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2015,

The ability to visualize biological processes in living organisms continuously, instead of at discrete time points, holds a great promise for studies of functional and molecular events, disease progression and treatment monitoring. Optical spectrum is particularly attractive for biological interrogations as it can impart highly versatile contrast of cellular and sub-cellular function as well as em ...
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 1

 TERMINÉ 

A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
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 33

 TERMINÉ 

Mechanisms of the Development of ALLergy (MEDALL)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2015,

Causes explaining the epidemic of IgE-associated (allergic) diseases are unclear. MeDALL (Mechanisms of the Development of Allergy) aims at generating novel knowledge on mechanisms of allergy initiation, in particular in childhood. To understand how a complex network of genetic and environmental factors leads to complex allergic phenotypes, a novel stepwise, large and integrative translational app ...
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 24

 TERMINÉ 

Infectious triggers of chronic autoimmunity (INTRICATE)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the ...
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 13

 TERMINÉ 

Deciphering mechanisms of ciliary disease (CiliaryDisease)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2015,

Ciliopathies are pleiotropic diseases with a wide spectrum of human phenotypes. These include cyst formation in the liver and pancreas, respiratory disorders and a predisposition to diabetes and cancer. The pleiotropic nature of these disorders may reflect the many roles cilia play in physiology and signalling, highlighting the clinical importance of understanding their function in organ developme ...
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 1

 TERMINÉ 

"CATO - CBRN crisis management: Architecture, Technologies and Operational Procedures" (CATO)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

"CATO proposes to develop a comprehensive Open Toolbox for dealing with CBRN crises due to terrorist attacks using non-conventional weapons or on facilities with CBRN material. CATO will:• combine CBRN knowledge, planning & response know-how, DSS building blocks and dedicated models and algorithms• enable the development of specific holistic CBRN-DSS• cover the entire CBRN disaster life cycle from ...
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 28

 TERMINÉ 

PREvention of Late Stent Thrombosis by an Interdisciplinary Global European effort (PRESTIGE)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,

"According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous ...
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 16

 TERMINÉ 

Reduction of Suicides and Trespasses on RAILway property (RESTRAIL)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The aim of the RESTRAIL project is to reduce the occurrence of suicides and trespasses on railway property and the costly service disruption these events cause, by providing the rail industry with an analysis and identification of cost-effective prevention and mitigation measures.The project starts by identifying the state of the art of best practices and research findings (inside and outside Euro ...
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 19

 TERMINÉ 

Next Generation in-vivo imaging platform for post-genome biology and medicine (MSOT)

Date du début: 1 mars 2009, Date de fin: 30 juin 2014,

With re-defined challenges in post-genome biology and medicine related to understanding the regulation and function of genes, proteins and multi-factorial disease, the development of accelerated and quantitative in-vivo observation of functional -omics at different system levels becomes a vital target. This proposal offers to develop therefore a next-generation biomedical imaging platform, designe ...
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 2

 TERMINÉ 

Groundwater and dependent Ecosystems: NEw Scientific basIS on climate change and land-use impacts for the update of the EU Groundwater Directive (GENESIS)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2014,

Groundwater resources are facing increasing pressure from consumptive uses (irrigation, water supply, industry) and contamination by diffuse loading (e.g. agriculture) and point sources (e.g. industry). This cause major threat and risks to our most valuable water resource and on ecosystems dependent on groundwater. New information is need on how to better protect groundwaters and groundwater depen ...
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 28

 TERMINÉ 

“Effect of diet on the mental performance of children” (NUTRIMENTHE)

Date du début: 1 mars 2008, Date de fin: 31 déc. 2013,

Current evidence on the effect of diet on mental performance (MP) is largely based on animal, retrospective studies, and short-term nutritional intervention studies in humans. NUTRIMENTHE will significantly improve this knowledge through studying the role, mechanisms, risks & benefits of specific nutrients & food components to respond to specific needs and improve the MP of children. The research ...
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 22

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

Development of rehabilitation technologies and approaches for multipressured degraded waters and the integration of their impact on river basin management (AQUAREHAB)

Date du début: 1 mai 2009, Date de fin: 31 déc. 2013,

Within the AQUAREHAB project, different innovative rehabilitation technologies for soil, groundwater and surface water will be developed to cope with a number of hazardous (nitrates, pesticides, chlorinated and aromatic compounds, mixed pollutions,…) within heavily degraded water systems. The technologies are activated riparian zones/wetlands; smart biomass containing carriers for treatment of wa ...
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 19

 TERMINÉ 

Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services (EUROGENTEST2)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe.This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the tar ...
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 22

 TERMINÉ 

European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2013,

"The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the developmen ...
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 19

 TERMINÉ 

“The International Data Coordination Centre” (I-DCC)

Date du début: 1 janv. 2009, Date de fin: 30 sept. 2013,

"The I-DCC coordination and support project responds to the topic defined by HEALTH-2007-2.1.2-6 “International activities in large-scale data gathering and systems biology”. I-DCC integrates European skills, efforts, resources, and infrastructure in an international collaborative programme to establish a European Data Coordination Centre for mouse genetic resources. Large-scale mouse mutagenesis ...
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 10

 TERMINÉ 

European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs (EurOCHIP)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply ...
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 10

 TERMINÉ 

Innovative Techniques and Models to Study Glia-Neuron Interactions (EdU-GLIA)

Date du début: 15 sept. 2009, Date de fin: 14 sept. 2013,

It became evident over the last 20 years that glial cells are involved in virtually every aspect of nervous system function. Neurons and glia exchange chemical signals that are essential for the normal function of the nervous system, and are crucial in disease. Recently it was discovered that glial cells also act as neural stem cells both in early development and adulthood, and in synapse formatio ...
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 14

 TERMINÉ 

Proteomics Standards International Molecular Exchange - Systematic Capture of Published Molecular Interaction Data (PSIMEx)

Date du début: 1 mars 2009, Date de fin: 31 août 2013,

The aim of the PSIMEx proposal is to systematically make published molecular interaction data computationally accessible. We plan to further develop the existing standard for molecular interactions developed by the HUPO Proteomics Standards Initiative, and to promote its implementation in the entire chain from experiment planning via data formatting and analysis to data representation in journal p ...
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 15

 TERMINÉ 

Multi-disciplinary biodosimetric tools to manage high scale radiological casualties (MULTIBIODOSE)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,

"In the event of a large scale radiological emergency biological dosimetry is an essential tool that can provide timely assessment of radiation exposure to the general population and enable the identification of those exposed people, who should receive medical treatment. A number of biodosimetric tools are potentially available, but they must be adapted and tested for a large-scale emergency scena ...
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 17