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Functional characterization of FAN1, a structure-specific DNA repair nuclease (FanDamAge)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,
DNA interstrand crosslinks (ICLs) are toxic lesions, which prevent the separation of strands necessary for DNA replication. ICLs arise in cells when common endogenous metabolites react with DNA and when cells are exposed to commonly used chemotherapeutic drugs, such as mitomycin-C (MMC) and cisplatin. Defects in the repair of endogenous ICLs cause Fanconi anaemia, characterized by chromosome insta ...
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