4 projets européens trouvés
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TERMINÉ
Long Non-coding RNAs with specific regulation and function in the Drosophila Central Nervous System (LNCRNADROCNS)
Date du début: 1 juil. 2014, Date de fin: 17 mars 2017,
The scientific and technical breakthrough of the draft sequence of the human genome in 2001 and the advent of genome wide technologies have dramatically altered our view of genome organization and function. We know now that more than 70% of the human genome is transcribed, although only 2% encode proteins. Within this huge percentage of supposedly “garbage” transcripts, thousands of long non-codin ...
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TERMINÉ
Mechanics of compaction in the mouse pre-implantation embryo (MECHACOMPA)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,
Compaction is the earliest morphogenetic event in mouse embryonic development during which blastomeres increase the size of their cell-cell interfaces. This permits the establishment of apico-basal polarity and thereby the 1st fate specification of the blastomeres: trophectoderm derives from blastomeres with a large apical membrane at the cell-medium interface; whereas blastomeres composing the in ...
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TERMINÉ
Characterization of the cellular mechanics of lineage segregation during mouse blastocyst morphogenesis by SPIM-based 4D-imaging and micromanipulation (SPIM MOUSE)
Date du début: 1 juin 2014, Date de fin: 31 mai 2016,
In mammalian development, the first cell lineages are established in the blastocyst, in which the inner cell mass (ICM) and the trophectoderm (TE) occupy distinct compartment along the embryonic inner-outer axis. The inner and outer cell layers in the embryo are generated during the transition from the 8-cell to 32-cell stage in principle by two dynamic processes, cell division and cell sorting. H ...
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TERMINÉ
Statistical methods for 3D imaging mass spectrometry in proteomics and metabolomics (3D-MASSOMICS)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2015,
Since biology is by and large a 3-dimensional phenomenon, 3D imaging has a significant impact on many challenges in life sciences. 3D matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is an emerging label-free 3D imaging technology with high potential in proteomics and metabolomics. 3D MALDI-IMS is based on 2D MALDI-IMS, which in the last years has proven its valu ...
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