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Single Molecule Imaging of the DNA Damage Response in Live Cells (SMI-DDR)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
"Accurate DNA replication is key to maintaining genomic stability. Replication is immensely complex requiring error-free duplication of several billion bases each time a human cell divides. The DNA replication machinery must deal with a wide range of DNA damage, aberrant secondary structures and DNA:protein complexes; obstacles that cause replication forks to arrest. Arrested replication complexes ...
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