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Role of Adipose DPP4 Deletion in Diet-Induced Obesity (ADDIO)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2015,

"Dipeptidyl peptidase-4 (DPP-4) is an exoprotease that cleaves N-terminal dipeptides from several substrates such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GLP), impairing the function of the incretin system, which is of key importance for glucose homeostasis. Indeed, DPP4 inhibitors are currently in clinical use for type 2 diabetes. The host group has described for th ...
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