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26 projets européens trouvés

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 EN COURS 
Understanding how brain controls social interactions is one of the central goals of neuroscience. Whereas social interactions and their effects on the emotional state of an individual are relatively well described at the behavioral level, much less is known about neural mechanisms involved in these very complex phenomena, especially in the amygdala, a key structure processing emotions in the brain ...
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 1

 TERMINÉ 
ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimer’s disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic co ...
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 8

 TERMINÉ 
FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of ...
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 11

 TERMINÉ 

International Doctoral Programme in Biological Bases of Human Diseases (Bio4Med)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

The major aim of Bio4Med (Biology for Medicine) programme is to provide unique, international, inter-disciplinary and inter-sectoral doctoral training for Early Stage Researchers (ESRs) in the domain of biological bases of human diseases. To achieve this goal it combines 22 leading research groups at the Nencki Institute and their scientific partners from world-class laboratories located in EU Mem ...
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 1

 TERMINÉ 

The Extracellular Matrix in Epileptogenesis (ECMED)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network ...
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 10

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Euro-BioImaging Preparatory Phase II - Project (EuBI PPII)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2017,

Euro-BioImaging (EuBI) is the pan-European research infrastructure project for imaging technologies in biological and medical sciences and has been on the ESFRI Roadmap since 2008. In close match with the scope and objectives of the INFRADEV2 call, Preparatory Phase II (PPII) funding will enable EuBI:• to finalize the submission and approval procedure of its ERIC statutes with the EC and bring the ...
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 21

 TERMINÉ 

nEUROinflammation

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuroinflammation is a hallmark of multiple sclerosis and ischemic stroke. Investigating neuroinflammation as a common theme in neurological disorders, this ITN will focus in particular on myeloid cells, microglia, and endothelial cells. Sixteen partners from the academic and private sector with complementary scientific background join forces to train 13 ESRs in neuroinflammatory concepts and tech ...
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 13

 TERMINÉ 
Brain disorders comprise a major burden for the society. Recent analyses of the neuropsychiatric disease-related gene polymorphisms as well as genomics and proteomics have identified the components of the extracellular matrix (ECM) and the cell adhesion molecules (CAMs) in the brain as pivotal for those diseases. The ECM/CAMs span the synaptic cleft and regulate the synaptic dynamics. Furthermore, ...
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 9

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2014, Date de fin: 30 sept. 2015,

This is a higher education student and staff mobility project, please consult the website of the organisation to obtain additional details.
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 1

 TERMINÉ 
"We identify Neuroelectronics as a novel mature discipline, at the boundaries between neurobiology, electrophysiology, computational neurosciences, microelectronics, materials sciences, and nanotechnologies. In the proposed Marie-Curie consortium, each of these components, as well as the specific application contexts (i.e. basic research, neuroprosthetics, and pharmaceutical applications), are rep ...
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 14

 TERMINÉ 
Cilia are microtubule (MT)-based external cell extensions that perform sensory and locomotory functions. Disruption of ciliary beating leads to human disorders such as infertility, airways diseases and hydrocephalus. The central pair of MTs (CP) apparatus is required for proper cilia motility yet the molecular mechanism that regulates its assembly is unknown. Loss of function mutations of MTs seve ...
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 1

 TERMINÉ 

BIO-IMAGing in research INnovation and Education (BIO-IMAGINE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

This Project aims at enhancing the potential of the Nencki Institute to participate actively in international research in neurobiology that uses cutting edge biological imaging techniques. Over the recent years bio-imaging has become the primary investigation method at the Institute and represents one of its strategic development areas for the next decade. A multi-level application of bio-imaging ...
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 1

 TERMINÉ 
Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

 TERMINÉ 

Role of the Grhl1 gene in skin cancer (Grhl1in skin cancer)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

Many functions of the Grainyhead-like (Grhl) transcription factors have already been studied in various animal models. So far these studies have been primarily concerned with the roles of such factors in development and wound healing. Now we have new preliminary data indicating that the Grhl factors are potential novel tumor suppressors. We have already established that the Grhl1-deficient mice ha ...
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 1

 TERMINÉ 

SRF target genes in epilepsy (EpiTarGene)

Date du début: 1 juin 2009, Date de fin: 29 nov. 2013,

The aim of this project is to identify genes regulated by SRF (Serum Response Factor) in the epilepsy. Epilepsy is a chronic neurological disorder, affecting 1-3% of human population with temporal lobe epilepsy (TLE) being the most common type in adults. Unfortunately, current anti-epileptic drugs are ineffective in more than 70% of TLE patients. Therefore, it is very important to understand the m ...
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 1

 TERMINÉ 

European Study to Establish Biomarkers of Human Ageing (MARK-AGE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variab ...
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 28

 TERMINÉ 

Affording Recovery In Stroke (ARISE)

Date du début: 1 mars 2008, Date de fin: 31 août 2013,

"Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and o ...
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 17

 TERMINÉ 
Understanding molecular basis of alcohol addiction still remains a great challenge for science and at the same time the only chance for designing successful molecular therapy. Calcium and calmoduline-dependent kinase II alpha (alpha CaMKII) is a major protein of forebrain glutamatergic neurons with well established function in various aspects of cell physiology, e.g. actin remodelling. Alcohol-ind ...
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 1

 TERMINÉ 
The aim of this project is to identify the microenviromental factors and their downstream cellular effectors determining the fate of adult CNS precursor cells which could be modulated in order to control remyelination process. Remyelination is the best example of regenerative processes in adult CNS, in which new myelin sheaths are restored to axons that have been demyelinated as a result of oligod ...
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 1

 TERMINÉ 
"Neurodegenerative diseases all cause damage to the circuitry of the nervous system, with loss of connections, axons and neurons. The loss can be gradual, as in Alzheimer’s disease, rapid as in stroke, or intermediate as in the delayed neuronal loss after stroke. Following damage, the nervous system is able partially to compensate through the formation of alternative connections and pathways, a pr ...
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 16

 TERMINÉ 

Axonal regeneration, plasticity & stem cells (AXREGEN)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

This is a multi-disciplinary training programme focussed on the experimental and clinical problems associated with axonal damage and repair in the central nervous system. This is a central feature of a wide variety of disorders of the CNS. Future advances in this area depend on training a cohort of young researches with multiple skills. The programme encompasses ten academic and two commercial org ...
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 13

 TERMINÉ 
The EECAlink is a coordination action aimed at identification of joint research priorities of the EU and EECA countries and strengthening scientific collaboration among them. International Cooperation Partner Countries targeted by our proposal are: Armenia, Belarus, Georgia, Kazakhstan, Moldova, Russia, Ukraine and Uzbekistan. EECAlink represents (i) a measure of active encouragement of the inter ...
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 17

 TERMINÉ 
Memory loss is a central symptom in different diseases, and represents a significant social and economic burden for a large percentage of European citizens. The molecular and neurobiological bases of memory deficits are largely unknown and there are currently no drugs available that can markedly decelerate or prevent memory decline. To address this major problem, this project will investigate the ...
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