6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Gene x environment interactions in affective disorders - elucidating molecular mechanisms (GxE-molmech)
Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,
Exposure to traumatic experiences as well as chronic stress has been shown to increase the risk for a number of psychiatric disorders including major depression and anxiety disorders by inducing longterm alterations in the reactivity of the stress hormone system. These effects can be moderated by genetic variants, one of them being functional polymorphisms in glucocorticoid receptor (GR) co-chaper ...
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1
Participant partenaire
TERMINÉ
Switchbox: Maintaining health in old age through homeostasis (SWITCHBOX)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,
Healthy aging requires maintenance of homeostatic control of the physiological systems and functions that are integrated by the hypothalamus. Driven by work in previous EU projects (Crescendo/Lifespan) highlighting insulin signalling and the hypothalamic/pituitary/adrenal and thyroid axes in the regulation of aging, SWITCHBOX will examine the flexibility of these neuroendocrine systems in response ...
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6
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TERMINÉ
Developmental Origins of Healthy and Unhealthy Ageing: The Role of Maternal Obesity (DORIAN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,
Europe has the highest proportion of elderly people in the world. Cardiovascular disease (CVD), type 2 diabetes (T2D), sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Obesity is a main health concern in the world. In the EU one-third of women of reproductive age are overweight and 20% are obese, a pr ...
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10
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TERMINÉ
Neuroendocrine Immune Networks in Ageing (NINA)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,
Current demographic trends indicate that by the year 2020 almost 1 in 5 of the European population will be aged over 65. However, although life expectancy is increasing in the developed world, the period of good health enjoyed by its people is not keeping pace. The ageing population is thus a major health and economic issue for Europe. Although ageing is a complex process, we know much about its a ...
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9
Participants partenaires
TERMINÉ
The functional significance of soluble amyloid beta (Abeta) oligomers for learning and memory deficits in Alzheimer's disease (AbetaCognition)
Date du début: 1 janv. 2011, Date de fin: 7 nov. 2013,
Alzheimer’s disease (AD) is characterised by a gradual cognitive decline, which initially affects learning and memory, and gradually impairs other cognitive functions. Despite considerable scientific effort, the cause and pathogenesis of AD is still unknown. Recent in vitro studies suggest that the destruction of synapses by soluble aggregates of amyloid beta (Abeta) might play a role in mediating ...
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1
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TERMINÉ
Synaptic mechanisms of memory loss: novel cell adhesion molecules as therapeutic targets (MemStick)
Date du début: 1 févr. 2008, Date de fin: 30 avr. 2011,
Memory loss is a central symptom in different diseases, and represents a significant social and economic burden for a large percentage of European citizens. The molecular and neurobiological bases of memory deficits are largely unknown and there are currently no drugs available that can markedly decelerate or prevent memory decline. To address this major problem, this project will investigate the ...
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