Rechercher des projets européens

20 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

PTX3 in Humoral Innate Immunity (PHII)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The innate immune system includes a cellular and a humoral arm. Structural diversity is a characteristic of humoral fluid phase pattern recognition molecules. These include complement components, collectins, ficolins, and pentraxins. We have used the long pentraxin PTX3, identified by the applicant (cDNA and genomic, mouse and human), as a prototypic fluid phase pattern recognition molecule to ...
Voir le projet

 1

 TERMINÉ 

Generation and maintenance of long-lived memory T cells in humans (PERSYST)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Defining the molecular mechanisms governing memory T cell differentiation and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers. Considerable knowledge in this regard has been acquired in mouse models but is still limited about human T cells. In particular, some mechanisms are assumed to occur in humans but were never formally d ...
Voir le projet

 1

 TERMINÉ 
ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) to determine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics for sepsis will be developed by buildin ...
Voir le projet

 7

 TERMINÉ 
Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative disorder of the brain and spinal cord affecting some 40,000 individuals in Europe, causing 11,000 deaths each year. Our pioneering work on riluzole showed that it is possible to modify ALS progression but all subsequent trials of potential neuroprotective agents have failed. Thus, drug development in ALS, including trial design, patient s ...
Voir le projet

 12

 TERMINÉ 
A key feature of the immune response is its specificity and macrophages must be able to discriminate precisely between an infectious stimulus and a non-infectious one and tune their response in accordance with the molecular context in which the target particle is recognized. In recent years, scientists have proposed the concept of the phagocytic synapse, to stress the fact that a particle does not ...
Voir le projet

 2

 TERMINÉ 

Epigenetics and microRNAs in Myocardial Function and Disease (CARDIOEPIGEN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2018,

Heart failure (HF) is the ultimate outcome of many cardiovascular diseases. Re-expression of fetal genes in the adult heart contributes to development of HF. Two mechanisms involved in the control of gene expression are epigenetics and microRNAs (miRs). We propose a project on epigenetic and miR-mediated mechanisms leading to HF.Epigenetics refers to heritable modification of DNA and histones that ...
Voir le projet

 1

 TERMINÉ 
... er Europe. The project will be carried out by the forerunners of robotic surgery in the field of urology. The European Association of Urology (NL), ORSI (BE), the University of Saarland (DE) and the Humanitas Research Hospital (IT) combined their state of the art knowledge and expertise, to develop these training programmes. The partners have a solid track-record on (1) the latest developments in ...
Voir le projet

 4

 TERMINÉ 
Innovative nanoparticle formulation for a miR-133 based treatment of cardiac hypertrophyCardiovascular diseases (CDs) are growing problems worldwide, affecting as much as 1% of the population. The causes include ischemic, toxic, genetic, post-inflammatory and structural defects; often multiple etiologies are present within an individual patient germane to the contraction failing, resulting in a mo ...
Voir le projet

 1

 TERMINÉ 
This project is focused on the development of novel nanomedicines effective in targeting the immunosuppressive, pro-tumoural, Tumour-Associated Macrophages (TAM) with the aim to manipulate the host’s immune system and improve anti-tumour responses. In most patients, chronic inflammation and immune suppression are the dominant effects in the tumour microenvironment. The infiltration of TAM in tumou ...
Voir le projet

 1

 TERMINÉ 

mRNA translational regulation in heart failure (MRNA IN HEART)

Date du début: 1 avr. 2014, Date de fin: 29 août 2016,

Protein synthesis is among the principal biological processes underlying cardiac hypertrophy, an early event in many forms of heart failure (HF). It is associated with worsening of cardiac function after long-term exposure to noxae. The rate-limiting step of protein synthesis is mRNA translation, which is controlled by factors involved in initiation and/or elongation. 4E-BPs regulate the translati ...
Voir le projet

 1

 TERMINÉ 
"Here we seek to identify the genetic program at the basis of T memory stem cell persistence in vivo and use their properties to improve the adoptive T cell transfer for the treatment of human cancer. Adoptive cell transfer with tumour-specific T lymphocytes is currently under test in the clinic for the treatment of solid tumours such as melanoma. However, the poor persistence in vivo of adoptivel ...
Voir le projet

 1

 TERMINÉ 
d-LIVER applies scenario-driven development methodologies to address an unmet need for bio-artificial liver support via continuous detoxification as remote transient therapy at the Point-of-Need. The liver is a complex organ with various vital functions in synthesis, detoxification and regulation; its failure is life-threatening and the only curative treatment is transplantation. Whilst awaiting t ...
Voir le projet

 15

 TERMINÉ 
Cardiometabolic diseases (CMD) (such as atherosclerosis, hypertension) are the primary cause of death and disability in the Western world. Although lifestyle programmes and therapeutic approaches have significantly reduced the socio-economic burden of CMD, a large number of events still cannot be avoided (residual risk). Neointimal hyperplasia is the principal pathogenic occurrence underlying athe ...
Voir le projet

 2

 TERMINÉ 
MicroRNAs (miRNAs) are non-coding RNA molecules that repress translation and stability of target mRNAs. They are key regulators of cell cycle and differentiation in embryonic stem cells, and are differentially expressed among many tumors, but their function in adult stem cells (SC) is not known. Somatic SC are able to self-renew, at the same time generating a differentiated progeny that replenish ...
Voir le projet

 1

 TERMINÉ 
"HIV is an urgent global health problem and a safe and effective vaccine is desperately required. Although many studies have shown that the innate immune system, and in particular, natural killer (NK) cells play a central role in determining the quality of the host immune response to HIV -1, the full host beneficial potential of the anti-HIV-1 NK-mediated activity can not be realized in vivo, as N ...
Voir le projet

 1

 TERMINÉ 
"This program encompasses the coordinated action of three major Biomedicine Research Centers and a Biotech shell in Lombardy, to launch a new Structured International Post-Doctoral program (SIPOD). These research centers operate in conjunction with the Scuola Europea di Medicina Molecolare (SEMM) whose aim is to promote the training and research of young scientists within emerging sectors of biome ...
Voir le projet

 4

 TERMINÉ 

The humoral innate immune system: long pentraxins as a paradigm (HIIS)

Date du début: 1 juin 2009, Date de fin: 31 mai 2014,

"The innate immune system consists of humoral and a cellular arm, but attention has largely been focused on cells and their receptors. The humoral innate immune system (HIIS) is generally represented as a collection of diverse molecules (collectins, ficolins, pentraxins). A tenet underlying this application is that in spite of molecular diversity, the HIIS is built on general principles and logic ...
Voir le projet

 1

 TERMINÉ 

Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
Voir le projet

 16

 TERMINÉ 
"Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammat ...
Voir le projet

 21

 TERMINÉ 

Role of innate immunity in the pathogenesis of autoimmune diseases (RIISPAD)

Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,

"We propose a multidisciplinary “translational research” project that will exploit the molecular and cellular features of innate immunity potentially involved in the pathogenesis of autoimmune diseases in humans. Given the significant scientific advances over the past years in characterizing the physiology of cells from the innate immune system, we will attempt to identify the role of natural kill ...
Voir le projet

 1