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 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

European Multicentre Tics in Children Studies (EMTICS)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2017,

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorder ...
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 33

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

Risk, Stem Cells and Tissue Kinetics – Ionising Radiation (RISK - IR)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,

The magnitude of cancer risk in humans exposed to low radiation doses (
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 16

 TERMINÉ 

Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2017,

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most rele ...
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 27

 TERMINÉ 

A common European approach to the regulatory testing of nanomaterials (NANOREG)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answe ...
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 73

 TERMINÉ 

Biomarkers For Enhanced Vaccine Safety (BIOVACSAFE)

Date du début: 1 mars 2012, Date de fin: 31 déc. 2016,

BioVacSafe is a concise consortium of selected academic, public, and SME participants used to co-working in industry-led projects, organised into focused Activity Cores to generate knowledge and tools to benchmark licensed vaccine reactogenicity, and create practical and generalizable guidelines and techniques to enhance immunosafety of novel vaccines from pre-development to post-marketing surveil ...
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 24

 TERMINÉ 
The rapid worldwide increase in mobile phone use in adolescents and, more recently, children has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. The current project aims to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on tumours of the central nervous system. The study ...
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 18

 TERMINÉ 
This proposal aims to close gaps that have been identified in nuclear and radiological preparedness following the first evaluation of the Fukushima disaster. It addresses the call Fission-2010-3.3.1: Update of emergency management and rehabilitation strategies and expertise in Europe. The consortium intends to review existing operational procedures in dealing with long lasting releases, address th ...
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 50

 TERMINÉ 

Realizing the European Network in Biodosimetry (RENEB)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

Creating a sustainable network in biological dosimetry that involves a large number of experienced laboratories throughout the EU will significantly improve the accident and emergency response capabilities in case of a large-scale radiological emergency. A well organised cooperated action involving EU laboratories will offer the only chance for a fast and trustworthy dose assessment urgently neede ...
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 28

 TERMINÉ 
... ound database and repository of selected test compounds, and a reference resource for cells, cell lines and tissues of relevance for in vitro systemic toxicity research carried out across the FP7 HEALTH.2010.4.2.9 Alternative Testing Strategies SEURAT program. The project develops infrastructure and service functions to create a sustainable predictive toxicology support resource going beyond the l ...
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 10

 TERMINÉ 

Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
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 16

 TERMINÉ 

Low Dose Research towards Multidisciplinary Integration (DOREMI)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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 39

 TERMINÉ 
Biomedical research depends on the availability of living non-human primates and biological material with primate origin. The need for animal research using non-human primates is therefore recognised by all governments that support internationally competitive biomedical research aimed at addressing the world’s most pressing medical challenges. While essential for biomedical research owing to their ...
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 13

 TERMINÉ 
The NANOPUR-project aims at leveraging on promising bottom-up technologies to develop intensified water treatment concepts based on nano-structured and nano-functionalized membranes as well as nanofilm deposition for micropollutants and virus removal.Major research needs targeted include the preparation of membranes with selective properties at the nanoscale able to maintain high permeability with ...
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 15

 TERMINÉ 
... n apoptosis, cell proliferation, differentiation and genomic instability will be explored with 2D cell cultures and 3D tissue models. This includes research on stem cells, which will be isolated from healthy human breast tissue. The results of the radiobiological studies will be integrated in the development of models of carcinogenesis for evaluation of major epidemiological cohorts: Atomic Bomb S ...
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 23

 TERMINÉ 
Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models ...
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 15

 TERMINÉ 

"Neutralizing antibodies against botulinum toxins A,B,E" (ANTIBOTABE)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2015,

"Botulinum neurotoxins (BoNTs), the most toxic substances known, are susceptible for use as bioweapons (listed as class A agents by CDC). Currently licensed animal derived antibodies or F(ab’)2 preparations, are at a high risk of inducing adverse effects and their privately-owned stockpiles are limited. In this project, we will target the most lethal types of BoNTs: A (subtypes A1 and A2), B (B1 a ...
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 11

 TERMINÉ 

Epidemiological Studies of Exposed Southern Urals Populations (SOLO)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,

This project aims to improve estimates of the risks of long-term health effects associated with protracted external and internal radiation exposures, through further studies of exposed populations in the Southern Urals (Russian Federation). Specific objectives of the project are as follows: 1. To develop improved modules for estimating external doses to exposed cohorts in the Southern Urals. It is ...
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 13

 TERMINÉ 

European Virus Archive (EVA)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2014,

"During the past 70 years or more, thousands of viruses have been isolated and partly characterised by experts working in different countries worldwide. These viruses potentially provide a unique and extremely valuable medical and educational resource for research and development to understand the basis of virus diseases, and to develop modern state of the art strategies for disease control. Howev ...
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 11

 TERMINÉ 
The objective of PRACTICE project is to improve the preparedness and resilience of the EU member states and associated countries to an attack from a terrorist group using non conventional weapons such as CBRN (Chemical, Biological, Radiological and/or Nuclear agents) materials. The existing situation is characterized by a fragmented structure as regards technology, procedures, methods and organiza ...
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 28

 TERMINÉ 

European Research Infrastructure on Highly Pathogenic Agents (ERINHA)

Date du début: 1 nov. 2010, Date de fin: 31 août 2014,

In the context of the emerging and re-emerging infectious diseases involving highly pathogenic microorganisms, European countries have to be well-prepared to face such threats. However, the Biosafety Level 4 (BSL4) capacity in Europe is not sufficient enough to cover the efficient development of diagnosis, prophylactic and therapeutics means against these pathogens. Moreover, there is no global co ...
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 27

 TERMINÉ 

Standardisation of laboratory analytical methods (SLAM)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

SLAM is a project proposal for a supporting and coordinating activity with the objective of reviewing the needs for standardisation of CBRN analysis and suggesting a road map for its implementation. All partners to the SLAM consortium are significant players in on-going dialogues on CBRN analytical requirements and procedures on the European scene. The composition of this consortium is well-balanc ...
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 10

 TERMINÉ 
"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
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 39

 TERMINÉ 
This project aims on the one hand to keep the momentum gained through the European Project EURANOS in establishing a platform where the operational and research community can meet and discuss with all the relevant stakeholders the topics related to emergency response and recovery preparedness and on the other hand to tackle urgent research topics in the area of nuclear emergency response and recov ...
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 22

 TERMINÉ 

European Clearing House for Open Robotics Development (ECHORD)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

Description Strengthening the knowledge transfer between scientific research and industry in robotics and stimulating their cooperation In Europe the robotics industry is strong, but still fragmented and dispersed. The objective of ECHORD is to provide new opportunities for coordinated and target- ...
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 105

 TERMINÉ 

Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

 TERMINÉ 

European Network of Vaccine Development and Research (TRANSVAC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"The TRANSVAC infrastructure will accelerate the pharmaceutical and clinical development of promising vaccine candidates by bringing the gap between academic research and clinical trials through carefully managing the advancement of promising vaccine candidates from preclinical animal models to early proof-of-principle studies in humans. Although expertise already exists within Europe spanning dif ...
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 18

 TERMINÉ 
"In the event of a large scale radiological emergency biological dosimetry is an essential tool that can provide timely assessment of radiation exposure to the general population and enable the identification of those exposed people, who should receive medical treatment. A number of biodosimetric tools are potentially available, but they must be adapted and tested for a large-scale emergency scena ...
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 17

 TERMINÉ 
We will determine the adverse and beneficial health effects of personal UVR exposure and their relationships with climatic and environmental factors that modify the solar UVR spectrum. Date and time stamped personal electronic wristwatch dosimeters will be worn to measure individual UVR exposure over extended periods. Satellite and ground station data will be gathered to establish terrestrial UVR ...
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 10

 TERMINÉ 
"As is the case with all nuclear expertise, there is a trend of a decreasing number of experts in radiation protection due to various reasons. On the other hand, current activities in the nuclear domain are expanding: the nuclear industry faces a so-called "renaissance", high-tech medical examinations based on ionising radiation are increasingly used, and research and non-nuclear industry also mak ...
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 13

 TERMINÉ 

European coordination action on human biomonitoring (COPHES)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2012,

... d including scientists, government institutions and authorities, NGOs and industry. The main goal is to develop a coherent approach to HBM in Europe as requested by ACTION 3 of the EU Environment and Health Action Plan through coordination of ongoing and planned HBM activities. The project will exploit existing and planned HBM projects and programmes of work and capabilities in Europe. The consort ...
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 40

 TERMINÉ 
Outstanding progress has been made in recent years in developing novel structures and applications for direct fabrication of 3D nanosurfaces. However, exploitation is limited by lack of suitable manufacturing technologies. In this project we will develop innovative in-line high throughput technologies based on atmospheric pressure surface and plasma technologies. The two identified approaches to d ...
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 22

 TERMINÉ 

Translational Research on Combating Antimicrobial Resistance (TROCAR)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

"The health care systems of most European countries are based on a continuum from acute care hospitals, though other health care facilities to the community. Such a framework provides the perfect opportunity for the wide-spread dissemination of high-risk resistant clones or genetic resistant elements. The driving concept of TROCAR is to investigate the fundamentals of the epidemiology of new high ...
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 14

 TERMINÉ 
"Enteric infections remain a major cause of morbidity and mortality globally, accounting for an estimated 2 millions deaths each year. Effective preventive and therapeutic interventions are not yet available for many etiological agents of diarrheal diseases. Furthermore, even where vaccines are available, the lag time needed to induce an immune response can be critical in epidemic situations. We ...
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 8

 TERMINÉ 

Nasal Pandemic Influenza Vaccine (NASPANVAC)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2012,

"The project is being undertaken in response to the need to develop an effective, user friendly, heat stable vaccine to control the highly pathogenic form of avian influenza virus (H5 and H7 subtypes) which has the potential to cause another global influenza pandemic. The overall objective of this programme is to develop a nasal avian influenza vaccine using ChiSys® (chitosan), which is a chitosan ...
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 8

 TERMINÉ 

Initiative on Optimizing Malaria Vaccine Lab Assays Evaluation (OPTIMALVAC)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2012,

"A broad-range of candidate malaria vaccines derived from diverse novel technologies have resulted from the multiple approaches being taken by different groups in developing malaria vaccines. The majority of the candidates are recombinant proteins based on complex native antigens found on the surface of the parasite. Vaccine potential of these parasite surface antigens is often supported by epidem ...
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 14

 TERMINÉ 

Human ModeL MATROSHKA for Radiation Exposure Determination of Astronauts (HAMLET)

Date du début: 1 sept. 2008, Date de fin: 30 sept. 2011,

"The European Space Agency’s project MATROSHKA (MTR), dedicated to determine the radiation load on astronauts in- and outside the International Space Station (ISS), launched in Jan. 2004 and is currently in its experimental phase 3. MTR is an anthropomorphic upper torso phantom containing over 6,000 radiation detectors to determine the depth- and organ dose distribution in the body. It is the larg ...
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 8

 TERMINÉ 
"Direct vaccination cannot prevent diseases that affect neonates in the first days of life. Group B Streptococcus (GBS) is the major cause of neonatal septicemia and meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that ...
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 10

 TERMINÉ 
"RANGER addresses the HEALTH-2007-2.3.3-4: Innovative point-of-care (POC) diagnostic tests for influenza call by providing a innovative solution to the immediate need for a rapid, robust, cost effective & user friendly POC diagnostic for influenza. We will develop the following real-time PCR system: 1) A robust, portable system allowing testing at the POC anywhere in the world 2) Raw sample to ...
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 9