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 TERMINÉ 

Does vascular endothelial growth factor gene therapy safely improve outcome in severe early-onset fetal growth restriction? (EVERREST)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

Fetal growth restriction (FGR) globally occurs in 8% of pregnancies, is severe and early onset in 1:500 cases, affecting 11,000 babies annually in the EU. In most cases, reduced uterine blood flow restricts substrate delivery to the fetus causing growth to slow or cease. There is no treatment. Currently the fetus is delivered very preterm before fetal death or irreversible organ damage occurs. Aff ...
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 10

 TERMINÉ 

The Milking Revolution in Temperate Neolithic Europe (NeoMILK)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

This project explores the introduction and spread of cattle-based agriculture by Neolithic Linearbandkeramik (LBK) farmers and its implications for modelling of the Mesolithic-Neolithic transition in Northern and Central Europe beginning ca. 8,000 years ago. This revolutionary shift in human subsistence strategy completely reshaped prehistoric European culture, biology and economy, in ways which u ...
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 4

 TERMINÉ 

Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) (NET4CGD)

Date du début: 1 déc. 2012, Date de fin: 31 mai 2018,

This project is focused on the clinical development of a new orphan drug that can rapidly become a new treatment option for patients with the X-linked form of chronic granulomatous disease (X-CGD). This rare primary immune deficiency of phagocytes is caused by mutations in the gp91phox gene. Affected patients are highly-susceptible to infections and develop inflammatory granulomas. Several member ...
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 11

 TERMINÉ 

PROduction and CONsumption: Textile Economy and Urbanisation in Mediterranean Europe 1000-500 BCE (PROCON)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

A textile is not simply a system of spun, twisted, or spliced fibres, but first and foremost a result of complex interactions between resources, technology, and society. Textile production and consumption is both ubiquitous and multi-faceted since, after food and shelter, textiles constitute the next most important necessity for people in all societies. Far from being a minor material, the product ...
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 2

 TERMINÉ 

Phase I/II Gene Therapy Trial of Fanconi anemia patients with a new Orphan Drug consisting of a lentiviral vector carrying the FANCA gene: A Coordinated International Action (EUROFANCOLEN)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Fanconi anemia (FA) is a rare inherited syndrome characterized by the early development of bone marrow failure and increasing predisposition to cancer with age. Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for hematopoietic manifestations of FA, although associated with complications arising from myeloablation, graft versus host disease and increased inciden ...
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 13

 TERMINÉ 

Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials ...
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 16

 TERMINÉ 

The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerativ ...
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 23

 TERMINÉ 

An international network of 50 CubeSats for multi-point, in-situ measurements in the lower thermosphere and re-entry research (QB50)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

The QB50 Project will demonstrate the possibility of launching a network of 50 CubeSats built by CubeSat teams from all over the world to perform first-class science and in-orbit demonstration in the largely unexplored middle and lower thermosphere. Space agencies are currently not pursuing a multi-spacecraft network for in-situ measurements in the middle and lower thermosphere because the cost of ...
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 17

 TERMINÉ 

Model-based preclinical development of anti-tuberculosis drug combinations (PREDICT-TB)

Date du début: 1 mai 2012, Date de fin: 30 oct. 2017,

Drug development in TB requires new integrated methods to transition the novel combination regimens needed to shorten first-line therapy and combat multi-drug resistance. Although new agents are emerging, the path to registration of such regimens remains uncertain while capacity for pivotal trials is limited. Selection and optimization of drug combinations for development depends on preclinical sy ...
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 23

 TERMINÉ 

Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn (THE HIP TRIAL)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2017,

Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategie ...
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 17

 TERMINÉ 

Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases (Neuromics)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics ...
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 20

 TERMINÉ 

Stem cells for Biological Assays of Novel drugs and prediCtive toxiCology (StemBANCC) (STEMBANCC)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

StemBANCC, comprising internationally renowned investigators, is ideally positioned to deliver a unique European biorepository and drug discovery pipeline based upon human induced pluripotent stem cells (hiPSC). This unrivalled opportunity will address the pressing therapeutic need in neurodegeneration, neurodysfunction and diabetes. We have immediate access to richly phenotyped subjects with a we ...
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 38

 TERMINÉ 

European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
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 29

 TERMINÉ 

Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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 17

 TERMINÉ 

European Multicentre Tics in Children Studies (EMTICS)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2017,

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorder ...
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 33

 TERMINÉ 

New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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 20

 TERMINÉ 

Indo-European Network in Mathematics for Health and Disease (INDOEUROPEAN-MATHDS)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

"The main aim of this proposal is to set up an Indo-European Research Network in Mathematics for Health and Disease, INDOEUROPEAN-MATHDS, that will allow the transfer of knowledge, research and training between partners. The Network will involve physicists, mathematicians, statisticians, probabilists, biologists, immunologists and engineers. The Network will create new collaborations and reinfor ...
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 7

 TERMINÉ 

Computational Horizons In Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Repositories for In Silico Oncology (CHIC)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

Developing robust, reproducible, interoperable and collaborative hyper-models of diseases and normal physiology is a sine qua non necessity if rational, coherent and comprehensive exploitation of the invaluable information hidden within human multiscale biological data is envisaged. Responding to this imperative in the context of both the broad Virtual Physiological Human (VPH) initiative and the ...
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 17

 TERMINÉ 

Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway (BIOtrachea)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal dis ...
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 13

 TERMINÉ 

Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

 TERMINÉ 

Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy (INSERT)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in ...
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 10

 TERMINÉ 

Anticorruption Policies Revisited. Global Trends and European Responses to the Challenge of Corruption (ANTICORRP)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The central objective of ANTICORRP is to investigate and explain the factors that promote or hinder the development of effective anticorruption policies and impartial government institutions. ANTICORRP directly addresses the objective in the Work Program by examining what the causes of corruption are, how corruption can be conceptualized, measured and analysed, what the impact of corruption on s ...
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 22

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

Intangible Treasures - Capturing the Intangible Cultural Heritage and Learning the Rare Know-How of Living Human Treasures (i-Treasures)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

Cultural expression is not limited to architecture, monuments or collections of artifacts. It also includes fragile intangible live expressions, which involve knowledge and skills. Such expressions include music, dance, singing, theatre, human skills and craftsmanship.These manifestations of human intelligence and creativeness constitute our Intangible Cultural Heritage (ICH). ICH is at the same t ...
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 17

 TERMINÉ 

Rational Bioactive Materials Design for Tissue Regeneration (BIODESIGN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art bioma ...
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 21

 TERMINÉ 

OncoTrack - Methods for systematic next generation oncology biomarker development (ONCOTRACK)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

We propose here an exhaustive analysis of the genome, exome, methylome and transcriptome of primary tumours and metastases from patients with colon carcinoma, based on a combination of deep sequencing and chip based techniques. Dependent on their availability, we shall also perform analyses of tumor stem cells, circulating tumor cells, free tumor DNA in serum and xenografts derived from the same p ...
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 22

 TERMINÉ 

Improving Popoulation Health Through Research Exchanges (IPHTRE)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"The quality of data on health at the population level varies widely across the world. In areas which lack general routine data (and which are often also impoverished in other respects), much can be learnt from detailed studies of populations in specific local areas. One such population in South Africa, the Agincourt Centre, occupies a world-leading position in this respect, having followed a defi ...
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 3

 TERMINÉ 

Wage Dynamics, Sorting Patterns in Labour Markets and Policy Evaluation (WASP)

Date du début: 1 mai 2011, Date de fin: 31 déc. 2016,

WASP is aimed at developing realistic empirical equilibrium search models of the labour market, with heterogeneous agents and long-term self-enforcing contracts, that• Can help better understand rent sharing mechanisms in labour markets, • Allow for multiple sources of productivity dynamics, including deterministic human capital accumulation and idiosyncratic productivity shocks, • Do not rule out ...
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 2

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

Proof of Concept of Model-based Cardiovascular Prediction (CARDIOPROOF)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

CARDIOPROOF is a proof-of-concept project that consolidates the outcomes of previous VPH projects and checks the applicability and effectiveness of available predictive modelling and simulation tools, validating them in interrelated clinical trials conducted in three European centres of excellence in cardiac treatment (from Germany, Italy and the UK). CARDIOPROOF focuses on patients with aortic va ...
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 10

 TERMINÉ 

NEURAL TRANSPLANTATION IN THE TREATMENT OF PATIENTS WITH PARKINSON’S DISEASE (TRANSEURO)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2016,

There are currently no cures for Parkinson's disease (PD) but one of the most effective reparative therapies in patients to date has been with allotransplants of dopamine (DA) neuroblasts obtained from fetal ventral mesencephalic (VM) tissue. However, this cell transplantation approach has given inconsistent results, with some patients doing extremely well and coming off anti-PD medication for yea ...
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 15

 TERMINÉ 

ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours (ASSET)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact ...
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 20

 TERMINÉ 

EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE (EPI-FEM-CARE)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,

CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or ...
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 6

 TERMINÉ 

Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency (CELL-PID)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ...
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 20

 TERMINÉ 

The evolution of cultural norms in real world settings (cultrworld)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2016,

An intense debate is raging within evolutionary anthropology as to whether the evolution of human behaviour is driven by selection pressure on the individual or on the group. Until recently there was consensus amongst evolutionary biologists and evolutionary anthropologists that natural selection caused behaviours to evolve that benefit the individual or close kin. However the idea that cultural b ...
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 1

 TERMINÉ 

ExoMol: molecular line lists for exoplanet atmospheres (ExoMol)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,

The discovery of extrasolar planets was one of the major advances of the last two decades. Over 400 planets have now been detected and astronomers are beginning to characterise their composition and physical characteristics. To do this requires huge quantities of spectroscopic data most of which is not available from laboratory studies. The interdisciplinary ExoMol project will provide acomprehens ...
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 1

 TERMINÉ 

Economic Cycles, Employment and Health: Disentangling Causal Pathways in a Cross-National Study (HEALTHCYCLE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

Research in economics suggests that business cycles are associated with population health: Physical health deteriorates during economic expansions and improves during recessions. At odds with these findings, research in epidemiology and sociology suggests that individual unemployment and job insecurity are associated with poor health and higher mortality. While studies on the impact of economic cy ...
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 4

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Exploring the Terauniverse with the LHC, Astrophysics and Cosmology (Terauniverse)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

The visible matter in the Universe is well described by the Standard Model, but this leaves open major questions in both particle physics and cosmology that may be answered by new physics at the Tera-electron-Volt range: the Terascale. The Large Hadron Collider (LHC) will soon open a new stage in humanity’s direct exploration of the fundamental physical laws at Terascale energies, which governed t ...
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 5

 TERMINÉ 

"Gene networks controlling embryonic polarity, regulation and twinning" (GEMELLI)

Date du début: 1 juin 2010, Date de fin: 29 févr. 2016,

"Much of what we know about how embryos determine their axes of symmetry comes from research in invertebrates (mainly Drosophila) and cold-blooded vertebrates (mainly Xenopus). In both cases, polarity is set up by the localisation of maternal determinants in the cytoplasm of the fertilised egg. These determinants are inherited differentially by daughter cells, leading them to acquire different fat ...
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 1