3 projets européens trouvés
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TERMINÉ
Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
"NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D ...
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13
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TERMINÉ
A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA)
Date du début: 1 juin 2010, Date de fin: 31 mai 2015,
AIM: To identify the molecular mechanisms characterizing cilium function, and the discrete perturbations associated with dysfunction caused by mutations in inherited ciliopathies, applying a systems biology approach. BACKGROUND: Cilia are microtubule-based, centriole-derived projections from the cell surface. They transduce extracellular signals and regulate key processes in which signals of the e ...
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17
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TERMINÉ
Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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