Date du début: 1 janv. 2017,
Date de fin: 31 déc. 2021,
Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b ...
Date du début: 1 sept. 2015,
Date de fin: 31 août 2019,
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
Date du début: 1 janv. 2015,
Date de fin: 31 déc. 2018,
Active pharmaceutical ingredients (APIs) can be released to the natural environment during the manufacturing process, following use by patients or when unused medicines are disposed of. As APIs are biologically active compounds concerns have been raised about the potential effects of APIs in the environment on human and environmental health. Over the past 15 years, a substantial amount of work has ...
Date du début: 1 avr. 2012,
Date de fin: 30 sept. 2017,
The long-term goal of this proposal is to explore a novel immune pathway that involves an unexpected interplay between marginal zone (MZ) B cells and neutrophils. MZ B cells are strategically positioned at the interface between the immune system and the circulation and rapidly produce protective antibodies to blood-borne pathogens through a T cell-independent pathway that remains poorly understood ...
Date du début: 1 janv. 2010,
Date de fin: 31 déc. 2016,
The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This will be achieved by coordinating the efforts of specialists from academia and SMEs in the wide scope of disciplines that are required to move towards a more reliable modell ...
Date du début: 1 sept. 2009,
Date de fin: 31 mai 2016,
Physical activity (PA) is essential in maintaining optimal health in chronic diseases, including COPD.More physically active patients have less hospital admissions and better survival. Validated physicalactivity monitors have become available in recent years, and together with patient report of symptomsand distress of physical (in)activity, this may form a potent new Patient Reported Outcome (PRO) ...
Date du début: 1 mars 2009,
Date de fin: 29 févr. 2016,
The rapid worldwide increase in mobile phone use in adolescents and, more recently, children has generated considerable interest in the possible health effects of exposure to radio frequency (RF) fields. The current project aims to assess the potential carcinogenic effects of childhood and adolescent exposure to RF and ELF from mobile telephones on tumours of the central nervous system. The study ...
Date du début: 1 mars 2011,
Date de fin: 28 févr. 2015,
"Anti-nuclear antibodies (ANAs) are the most common types of autoantibodies in SLE. Elevated levels of ANAs belonging to the IgD class have long been observed in SLE patients, reflecting dysregulation of the IgD compartment, but the significance of this dysregulation in SLE pathogenesis is completely unknown. IgD in healthy individuals reacts more frequently with nuclear antigens than IgG, the ant ...
Date du début: 1 mai 2012,
Date de fin: 30 avr. 2014,
Hematopoietic Stem Cell (HSC)-based therapies are becoming a great expectation for the cure of several disorders that require HSCs for treatment. However, the incapacity to generate and maintain fully potent transplantable HSCs in vitro is still nowadays one of the main limitations for their wide application in cellular therapies. The study of the molecular mechanisms underlying HSC ontogeny in em ...
Date du début: 1 févr. 2011,
Date de fin: 31 juil. 2013,
Biomedical Informatics deals with the integrative management and synergic exploitation of the wide ranging and inter-related scope of information that is generated and needed in healthcare settings, biomedical research institutions and health-related industry.Some key present challenges of Biomedical Informatics are:- The effective and synergic integration between computational methods and technol ...
Date du début: 1 janv. 2008,
Date de fin: 30 juin 2013,
"The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seaml ...
Date du début: 1 janv. 2010,
Date de fin: 30 juin 2013,
The ability of some compounds to prolong the QT interval of the electrocardiogram and to precipitate Torsade de Pointes (TdP, a potentially fatal arrhythmia) has caused several regulatory interventions, including drug withdrawals. Specific guidelines have been implemented to detect QT liability of new compounds as early as possible. However there is growing evidence that an increase in the QT inte ...
Date du début: 1 nov. 2008,
Date de fin: 30 avr. 2012,
"The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs). The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD an ...
Date du début: 1 févr. 2008,
Date de fin: 31 janv. 2012,
Serious adverse effects resulting from the treatment with thalidomide prompted modern drug legislation more than 40 years ago. Post-marketing spontaneous reporting systems for suspected adverse drug reactions (ADRs) have been a cornerstone to detect safety signals in pharmacovigilance. It has become evident that adverse effects of drugs may be detected too late, when millions of persons have alrea ...
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