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 EN COURS 

Mechanism of centriole inheritance and maintenance (CentrioleBirthDeath)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Centrioles assemble centrosomes and cilia/flagella, critical structures for cell division, polarity, motility and signalling, which are often deregulated in human disease. Centriole inheritance, in particular the preservation of their copy number and position in the cell is critical in many eukaryotes. I propose to investigate, in an integrative and quantitative way, how centrioles are formed in t ...
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 1

 EN COURS 
The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st ...
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 33

 EN COURS 
Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options outside of infection control and organ support measures. Based on our recent discovery that anthracycline drugs prevent organ failure without affecting the bacterial burden in a model of severe sepsis, we propose that strategies aimed at target organ protection have e ...
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 1

 EN COURS 
Genome stability relies on accurate partition of the genome during nuclear division. Proper mitosis, in turn, depends on changes in chromosome organization, such as chromosome condensation and sister chromatid cohesion. Despite the importance of these structural changes, chromatin itself has been long assumed to play a rather passive role during mitosis and chromosomes are usually compared to a “c ...
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 1

 TERMINÉ 

YOUNG OPERA MAKERS Programme by enoa

Date du début: 11 mai 2016, Date de fin: 10 mai 2020,

YOUNG OPERA MAKERS PROGRAMME by enoaThe role of creation, development of new forms, exploration of innovative creative processes and audience renewal are all major challenges facing today’s European opera world. Young artists must be the drivers of this change: their training and employability are crucial issues. In a globalized and competitive sector young artists should be fundamentally mobile a ...
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 13

 TERMINÉ 

Alternative splicing and SR proteins in ABA-mediated plant stress responses (AS-ABA)

Date du début: 1 sept. 2017, Date de fin: 31 août 2019,

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and ...
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 1

 TERMINÉ 
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Mechanisms of Chromatin-based Epigenetic Inheritance (EpiMechanism)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

Epigenetic mechanisms heritably maintain gene expression states and chromosome organization across cell division. These include chromatin-based factors that are propagated independent of local DNA sequence elements, and are critical for normal development and prevent reprogramming, e.g. during induction of pluripotency. We focus on the role of nucleosomes, the histone-DNA complexes that make up ch ...
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 1

 TERMINÉ 

REGULATORY T CELLS AND TISSUE DAMAGE CONTROL (REGDAM)

Date du début: 1 avr. 2017, Date de fin: 31 mars 2019,

Regulatory T cells (TREG) are critical players in the control of innate and adaptive immune responses while impacting as well on the functional output of parenchyma tissues. This later effect is exerted by tissue-resident TREG, via an ill-defined mechanism that modulates tissue damage control, that is, a protective response of parenchyma tissues that limits cellular dysfunction and/or damage impos ...
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 1

 TERMINÉ 
For the most disadvantaged children, high quality early childhood services can make a tremendous difference in reducing disparities in learning outcomes. Currently, high inequality in the Early Childhood Education and Care (ECEC) systems in Europe has a strong impact on the most vulnerable groups: migrant children, Roma children, children with special needs, children living in poverty. This projec ...
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 9

 TERMINÉ 
Maintaining a stable karyotype is essential for the use of pluripotent stem cells (PSCs) in regenerative medicine and translational and basic research. Although around 10-30% of PSC lines present karyotypic abnormalities, the molecular mechanisms underlying this genomic instability are largely unknown. Centromeres, the chromosomal loci that drive chromosome segregation are central to mitotic fidel ...
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 1

 TERMINÉ 
My goal is to understand how cell-autonomous immunity (CAI) can detect intracellular parasites such as Toxoplasma gondii in their membrane-bounded intracellular niches, how recognition induces necrosis of the host cell, and how host death signalling pathways contribute to inflammatory disorders. Although adaptive immunity ultimately contributes to host survival, the initial response is controlled ...
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 1

 TERMINÉ 
Assessing the stress resilience of optimistic and pessimistic phenotypes is crucial for the study of stress-related mental disorders (SRMD) in humans (e.g., anxiety and depression). However, only by understanding the neural mechanisms of cognitive bias and its role in the triggering of the stress response can these personality traits be meaningfully linked to susceptibility to SRMD. In this way, B ...
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 1

 TERMINÉ 

"Intramembrane Proteases, their Inactive cognates, and Disease" (IPAD)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

"The ability to release signals from the cell surface is dependent on the correct functioning of the secretory pathway. This proposal focuses on trafficking regulation and quality control within the secretory pathway by members of the rhomboid superfamily, and members of the Signal Peptide Peptidase-Like family (SPPL).The metalloprotease TACE (TNF alpha converting enzyme) is an important sheddase ...
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 1

 TERMINÉ 

The mechanics of nuclear division and positioning (Mechanicus)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

During mitosis the genetic material of the mother cell is separated and distributed between two daughter cells. Responsible for this coordinated segregation is an assembly of polymers, molecular motors and adapter proteins– the mitotic spindle. This super-molecular machine moves the chromosome halves in opposite directions over impressive cellular scales (tens of µm) within a relatively short time ...
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 1

 TERMINÉ 
"We propose to study evolutionarily conserved stress-responsive protective mechanisms that limit the extent of tissue damage caused by pathogens or by the innate as well as adaptive immune response elicited by those pathogens, which, without a countervailing response would lead to irreversible tissue damage and disease. We refer to these protective mechanisms as “tissue damage control”, and will a ...
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 1

 TERMINÉ 

Control of Centriole Structure And Number (CentriolStructNumber)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Centrioles are essential for the formation of several microtubule organizing structures including cilia, flagella and centrosomes. These structures are involved in a variety of functions, from cell motility to division. Centrosome defects are seen in many cancers, while abnormalities in cilia and flagella can lead to a variety of human diseases, such as polycystic kidney disease. The molecular mec ...
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 1

 TERMINÉ 

Chromosome Condensation and Cohesion (CCC)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"Accurate cell division relies on the fact that the genetic information encoded in the DNA molecules is equally segregated into the two daughter cells. Proper partitioning of the genome, in turn, depends on two key changes in chromosome organization: 1) chromatin is converted into compact structures with the right mechanical properties (size, flexibility, rigidity) to facilitate their segregation; ...
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 1

 TERMINÉ 
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:• Develop a series of mutant alleles for every gene in the mouse genome• Determine the phenotypic consequences of each mutation• Identify mouse models for the complete dise ...
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 24

 TERMINÉ 

Innovation and social learning in HEI

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2016,

The ISOLearn project is in line with the principles stated in main charters and declarations of intention by major international and European institutions and governments (e.g. UN Convention on the Rights of Persons with Disabilities (Article 24, Education); Salamanca Statement on Special Needs Education (1994); (European Convention on Human Rights), Article 2 Right to Education; European Social ...
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 8

 TERMINÉ 
Today’s teacher’s are confronted with mastering the huge amount of digital skills and simultaneously also challenged by the need to be updated and to be innovative and creative in a world were the digital format constitutes an indispensable bridge towards the day by day reality of the students. The idea is to reinforce digital bridges of communication in a learning and teaching context, seeking to ...
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 7

 TERMINÉ 

TOO YOUNG TO FAIL

Date du début: 1 sept. 2014, Date de fin: 31 août 2016,

Early school leaving is the result of a mix of individual, educational and socio-economic factors. Many triggering effects make ESL a complex multisector phenomenon: school failure (disengagement, low achievement, transition between schools and school levels), pull effects from labour market, social and family situation. If it differs from country to country and from region to region, there are s ...
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 9

 TERMINÉ 
Telomeres are DNA-protein complexes that reside at the end of the chromosomes. These are key structures in order to prevent loss of genetic information and DNA damage activation at the chromosome termini, thus avoiding genomic instability, which can potentiate tumorigenesis. When a telomere became dysfunctional, for example by loss of telomeric proteins or due to telomere shortening, the DNA damag ...
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 1

 TERMINÉ 
"Current interest in neural stem cells derives from the prospect of using them in brain repair strategies, but also to understand neurodevelopmental pathologies. This will require, however, a significant improvement of our understanding of the gene expression programs associated with their maintenance and differentiation, and how these are regulated. Recently, several lines of evidence suggest a ...
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 1

 TERMINÉ 
The process of adaptation to novel environments is of extraordinary importance to understand the existence of biological diversity. The development of a theory of adaptation during the last 150 years identified natural selection as its cause, and the conditions under which it depends on the existence of the heritable variation encoded in DNA sequences, introduced in finite populations by mutation, ...
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 2

 TERMINÉ 

Optogenetic Analysis of Serotonin Function in the Mammalian Brain (5HT-OPTOGENETICS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2015,

Serotonin (5-HT) is implicated in a wide spectrum of brain functions and disorders. However, its functions remain controversial and enigmatic. We suggest that past work on the 5-HT system have been significantly hampered by technical limitations in the selectivity and temporal resolution of the conventional pharmacological and electrophysiological methods that have been applied. We therefore propo ...
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 2

 TERMINÉ 

Microbial adaptation within ecosystems (ECOADAPT)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2015,

All natural populations are constantly subject to new mutations, and frequently face new environments, to which they adapt. Knowledge of the genetics of adaptation should provide the centerpiece of a unified theory of evolution. Despite its extreme importance, the process of adaptation is far from being understood. How does the shape of distribution of fitness effects of mutations depend on the en ...
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 1

 TERMINÉ 

Targeted research effort on African swine fever (ASFORCE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2015,

"African Swine Fever (ASF) is a devastating disease affecting swine caused by a complex virus, the only member of the Asfarviridae family. Disease transmission is maintained under different and complex epidemiological scenarios involving domestic and wild swine and arthropod vectors (soft ticks Ornithodoros sp). Due to the fact that no vaccine has been obtained so far, prevention, control, and era ...
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 20

 TERMINÉ 
Symbiosis is a major adaptive process allowing bacteria to interact with other organisms to colonise diverse and adverse environments. The genetic mechanisms behind these symbioses are poorly understood despite the fact that some have a major weight on human health and/or welfare. The goal of this project is to investigate the molecular mechanisms involved in monospecific bacterial-host interactio ...
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 1

 TERMINÉ 

Novel immunotherapies for type 1 diabetes (NAIMIT)

Date du début: 1 nov. 2009, Date de fin: 30 avr. 2015,

This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on a solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted for future clinical application. Four work packages are grouped around ‘Reversal of autoimmunity’, in which two ke ...
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 15

 TERMINÉ 

Metabolic Reprogramming by Induction of Transcription (MERIT)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

Plants continually monitor the environment to modify physiology and development at the molecular level to ensure maximal fitness. Central in the signaling network is the SnRK1 kinases (homologous to AMPK and SNF1 in mammals and yeast respectively). These kinases are vital to the energy balance of the organism and regulate primary metabolism by controlling transcription factors, which control the e ...
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 8

 TERMINÉ 

Epithelial Resealing (RESEAL)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2014,

Epithelia have the essential role of acting as a barrier that protects living organisms and its organs from the surrounding milieu. Therefore, it is crucial for epithelial tissues to have robust ways of maintaining its integrity despite the frequent damage caused by normal cell turnover, inflammation and injury. All epithelia have some capacity to repair themselves, however, the wound-healing proc ...
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 2

 TERMINÉ 
In every day life, we constantly have to select the appropriate actions to obtain specific outcomes. Actions can be selected based on their consequences, for example when we press an elevator button to get to the particular floor where we live. This goal-directed behaviour is crucial to face the ever-changing environment but demands an effortful control and monitoring of the response; one way to b ...
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 2

 TERMINÉ 
"Sexual reproduction is a fundamental biological process common among eukaryotes. In angiosperms, fertilization although associated with pollination, is actually a fairly late phenomenon in the process of reproduction and involves a double fusion event between two male and two female gametes. In contrast to animal fertilization, the molecular mechanisms underlying this process in flowering plants ...
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 1

 TERMINÉ 

PLANT developmental biology: discovering the ORIGINS of form (PLANTORIGINS)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2014,

"The main objective of PLANTORIGINS-ITN is to improve career prospects of young researchers in the growing field of plant evolutionary developmental biology through a programme of research, training and transfer of knowledge that integrates new discoveries and approaches in the fields of plant morphology, systematics, and developmental genetics with the overall goal of understanding the origins of ...
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 7

 TERMINÉ 

Innate Neuronal Circuits (INC)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

"Animals exhibit behavioral repertoires that are often innate and result in stereotyped sexual and social responses to their environment. Sexual behaviors represent a robust set of innate responses. Genetic studies in Drosophila strongly imply the FruM, a male-specific isoform of the fruitless gene in programming male courtship. The circuit of female behavior on the other has been largely uncharac ...
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 1

 TERMINÉ 

Neural Mechanisms Underlying Mate Preference and selection in Mice (MCM)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"Mate choice is a behavior observed through all animal kingdom with deep evolutionary consequences, since only the genes of animals that can successfully mate will pass to the next generation. If not everybody has the ability of passing its genes, this means that each individual looks different at the eyes of choosers, which has classically been approached in terms of attractiveness. Mate selecti ...
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 1

 TERMINÉ 
"DNA damage response (DDR) monitors chromosome status to ensure correct homologous recombination, genomic integrity and chromosome segregation. Thus the effect of DDR activation upon exogenous DNA breaks has been intensely studied. Less is known about the effects of such mechanisms due to endogenous breaks. In multicellular organisms meiosis is a classical example of double strand break (DSB) prod ...
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 1

 TERMINÉ 

Developing the Framework for an Epidemic Forecast Infrastructure (EPIWORK)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,

In recent years a huge flow of quantitative social, demographic and behavioural data is becoming available spurring the quest for innovative technologies that can improve the traditional disease-surveillance systems, providing faster and better localized detection capabilities and resulting in a broad practical impact. Improved ICT techniques and methodologies support the inter-linkage and integra ...
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 12

 TERMINÉ 

Neural mechanisms of action learning in mouse models (Neuroaction)

Date du début: 1 août 2009, Date de fin: 31 juil. 2013,

The learning of novel skills is characterized by an initial stage of rapid improvement in performance, followed by a phase of more gradual improvements as the skills are automatized and performance asymptotes. Although the striatum has been implicated in skill learning, the detailed mechanisms and circuits underlying its role in the acquisition and consolidation of skills are not understood. Usin ...
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 1