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 TERMINÉ 
... may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD.To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The pri ...
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 38

 TERMINÉ 

Molecular basis of the outer membrane permeability (TRANSLOCATION)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

Overcoming the barriers that the cell envelope and efflux pumps provide to Gram-negative bacteria is a major bottleneck in the discovery and development of new antibiotics. To respond to this Call we are extending our current network on antibiotic translocation and propose an ambitious project ranging from identification of novel resistance mechanisms in clinical bacterial isolates to crystallizat ...
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 28

 TERMINÉ 
Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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 20

 TERMINÉ 
"""LCA to go"" develops sectoral methods and tools for bio-based plastics, industrial machinery, electronics, renewable energy, sensors and smart textiles. These sectors have been chosen, as the manufacturers show a high interest in making clear the environmental benefits of their products to customers (""Green industries"") and in prioritizing so they can reduce their environmental impacts. This ...
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 18

 TERMINÉ 
...m. It will be a flexible tool that can be adapted and used for applications beyond the scope of REACH and in the post-REACH period. It will use in silico methods for prescreening chemicals for all relevant toxic effects. When found positive, this will be followed by further in silico and in vitro tests, most of which are available already. To fill the gap of suitable alternative methods for reprod ...
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 11

 TERMINÉ 
...ed or novel treaty provisions becomes a high priority for interdisciplinary research-based teaching curricula in EU studies. Only a European academic network will be able to exploit input from the relevant disciplines with wide geographical coverage. LISBOAN promotes synergies between research and teaching, highlights innovative approaches and establishes best practices in teaching this key issue ...
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