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Influenza neuraminidase (NA) is the enzyme that releases influenza virions from the infected cells, cleaving the sialic acid receptor on host cells. It has been recently demonstrated that influenza A has neuraminidase subtypes that belong to two distinct subgroups. The crystal structures of the three subtypes N1, N4 and N8 (group-1 enzymes) were found to be virtually identical in the shapes of the ...

"A number of methods exist for the production of enantiopure pharma intermediates. Among them, classical resolution by crystallization is the least efficient and most used one, while asymmetric catalysis, arguably the most efficient, is much less used. This paradox is due to a number of factors, such as: 1. High cost of the catalyst. 2. Lack of scope. 3. Time-to-market pressure. In this project we ...