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17 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

The ecology of metabolic phenotypes: from cells to populations (METAPHEN)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"Metabolic rate is a fundamental life history trait. Yet it also shows remarkable intra-specific variation: some individuals consistently have 2-3 times the maintenance costs of conspecifics the same size, age and sex. The predicted consequences of this variation are central to our understanding of optimal life history strategies and resource allocation trade-offs. But how is this intra-specific v ...
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 1

 TERMINÉ 

Defining the cellular interactions that control the retention of and tolerance induction in CD4 T cells at inflammatory sites (CD4InEar)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

Inflammatory sites contain a number of different cell types that contribute to the swelling and the destruction of surrounding tissue. In rheumatoid arthritis this inflammation occurs at joints. The cells implicated in coordinating and amplifying this damage are CD4 T cells. Much is known about the mediators responsible for attracting CD4 T cells into inflammatory sites. However, the signals respo ...
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 1

 TERMINÉ 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

Targeting microRNAs for ColoRectal Cancer Therapy (TAMIRCRT)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

MicroRNAs are small non-coding RNAs involved in cell homeostasis and carcinogenesis. MicroRNA deregulation is associated with colorectal cancer (CRC) progression. My study proposes to identify genetic and epigenetic events leading to microRNAs deregulation and use them as targets for drug development. My research proposal will address two important questions. First it will assess the contribution ...
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 2

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 

Towards Early diagnosis and biomarker validation in Arthritis Management (EURO-TEAM)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

An ideal intervention in a chronic inflammatory disease such as Rheumatoid Arthritis (RA) would be a preventive one. In order to develop preventive strategies and therapies two key developments need to occur: (1) Biomarkers need to be identified that can be used to predict an individual’s risk of developing RA. (2) Modifiable disease mechanisms need to be identified and characterized in the early ...
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 17

 TERMINÉ 

Electronic Health Record systems for Clinical Research (EHR4CR)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

Current medical needs, the growth of targeted therapies and personalized medicines, and escalating R&D costs result in formidable cost pressures on healthcare systems and the pharmaceutical industry. Clinical research is also growing in complexity, labour intensity and cost. There is a growing realization that the development and integration of Electronic Health Record systems (EHRs) for medical ...
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 37

 TERMINÉ 

Interfacing Oxides (IFOX)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2015,

The goal of IFOX is to explore, create and control novel electronic and magnetic functionalities, with focus on interfaces, in complex transition metal oxide heterostructures to develop the material platform for novel ‘More than Moore’ (MtM) and ‘beyond CMOS’ electronics, VLSI integratable with performance and functionality far beyond the state-of-the-art. To this end it will:-Establish a theoreti ...
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 19

 TERMINÉ 

Advanced SuperConducting devices for ENhanced infrared Detection (ASCEND) (ASCEND)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,

"This Marie Curie Fellowship proposal is aimed at developing a novel type of infrared single photon detector to meet the stringent requirements of advanced imaging, quantum communications and remote sensing applications. This will be achieved by exploiting the potential of superconducting nanowire single photon detectors (SNSPDs) when detecting infrared photons of energy below 1eV. Excellent signa ...
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 1

 TERMINÉ 

Identification and therapeutic targeting of common arrhythmia trigger mechanisms (EUTRIGTREAT)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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 15

 TERMINÉ 

European large-scale functional genomics in the rat for translational research (EURATRANS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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 19

 TERMINÉ 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

 TERMINÉ 

Study of Strongly Interacting Matter (HADRONPHYSICS3)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The Project promotes the access to five European Research Infrastructures, and it is structured into nine Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities.The Project will profit of the success of the previous HadronPhysics project in FP6 and the current HadronPhysics2 in FP7, and originates from the initiative of more than 2.500 European scienti ...
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 52

 TERMINÉ 

Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices (Masterswitch)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity. State of the Art and beyond: The ...
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 20

 TERMINÉ 

TERASCALE RELIABLE ADAPTIVE MEMORY SYSTEMS (TRAMS)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

Technology projections indicate that future electronic devices will keep shrinking, being faster and consuming less energy per operation. In the next decade, a single chip will be able to perform trillions of operations per second and provide trillions of bytes per second in off-chip bandwidth. This is the so called Terascale Computing era, where terascale performance will be mainstream, available ...
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 4

 TERMINÉ 

Clinical Continuity by Integrated Care (Homecare)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2012,

Our comprehensive approach to clinical continuity by integrated care (IC) across the secondary-primary interface departs from a preliminary literature review selecting frequent chronic conditions (CC) as stroke, COPD and HF as our focus areas. However, within each of these areas IC is a small activity, still, requiring more basic research. As IC for these different CC are based on the same patient ...
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 13

 TERMINÉ 

The evolution of post-orogenic landscapes: bedrock rivers, lithology and relief development (PostOroLand)

Date du début: 1 juin 2009, Date de fin: 31 mai 2011,

Post-orogenic landscapes occupy by far and away the bulk of the Earth’s surface but their evolution remains under-researched and poorly understood, providing the central motivation for this proposal. The principal outcome will be the testing of competing models for post-orogenic landscape evolution. The proposal is strongly linked to studies that analyse how climatic and tectonic factors influence ...
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 1