20 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Modelling the mechanisms of nanoparticle-lipid interactions and nanoparticle effects on cell membrane structure and function (MEMBRANENANOPART)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,
The central goal of our proposal is to develop physically justified models and computational tools to quantitatively describe and understand the molecular mechanisms of nanoparticle-cell membrane interactions, which we consider to be a crucial point in any predictive model of nanoparticle toxicity. We consider mechanisms of nanoparticle protein corona formation, the protective function of the memb ...
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4
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TERMINÉ
Charge Carrier Transport in Soft Matter: From Fundamentals to High-Performance Materials (SOFTCHARGE)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,
... and small energy barriers for CT, which renders standard theories such as band theory or activated electron hopping in many cases entirely inadequate. Here, I propose the development of a disruptive computational method‚ based on non-adiabatic molecular dynamics (NAMD), that will open the door for ground-breaking new insight into this problem. The method will be able to access length and time sca ...
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1
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TERMINÉ
Bird Inspired Autonomous Flight (BIAF)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,
...at bird flight behaviour and aerodynamics. The first track looks at developing path planning algorithms for UAVs in urban environments based on how birds fly in these areas, by using GPS tracking and computational fluid dynamics alongside trajectory optimization. The second track aims to develop artificial wings with improved gust tolerance inspired by the features of feathered wings. Here, high s ...
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1
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TERMINÉ
IMMUNOBIOLOGY OF LYMPHOID STROMAL CELLS (STROMA)
Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,
...med LNs and (iii) their subsequent fate in LNs that have returned to homeostasis. To this aim, I have developed several original, cutting-edge multicolor fluorescent reporter mouse models and computational modeling approaches to map the fate of single stromal cells and their progeny in situ. Using this innovative approach, my group will investigate the spatio-temporal behavior and molecular cues t ...
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2
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TERMINÉ
Programming in vitro evolution using molecular fitness functions (ProFF)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
...ysts working in non-natural environments, possibly build from non-natural chemistries and targeting an unlimited range of non-natural functions. However, their design is still an arduous process; computational design lacks precision while the combinatorial approach, directed evolution, is limited by labor-intensive or ad hoc selection stages.We will remove the selection bottleneck in directed evol ...
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1
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TERMINÉ
Phosphonic Acids: Surface Electrochemistry (PHASE)
Date du début: 3 déc. 2014, Date de fin: 2 déc. 2016,
...ic force microscopy and the recently developed in situ infrared technique, PM-IRRAS (Polarisation Modulation Infrared Reflection Absorption Spectroscopy). These results will be combined together with computational simulations, a combination of density functional theory and molecular dynamics simulations, to form a complete picture of the surface aggregation phenomena of these molecules. The strate ...
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1
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TERMINÉ
Improving the selectivity of kinase inhibitors: Characterizing binding mechanisms of inhibitors targeting inactive states and allosteric sites (KIBinding)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
... many different conformations and provide a clear picture of the mechanisms of inhibitor binding. Since straightforward molecular dynamics simulations suffer from a time scale problem we use a novel computational technique, metadynamics, to enhance sampling. Using metadynamics calculations we propose to investigate the binding mechanisms of inhibitors which target the inactive conformation and a ...
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2
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TERMINÉ
Industrial optimal design using adjoint CFD (IODA)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Adjoint-based methods have become the most interesting approach in numerical optimisation using Computational Fluid Dynamics (CFD) due to their low computational cost compared to other approaches. The development of adjoint solvers has seen significant research interest, and a number of EC projects have been funded on adjoint-based optimisation. In particular, partners of this proposal are member ...
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10
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TERMINÉ
Development of multi-level electron correlation methods in quantum chemistry (NewQuantum)
Date du début: 1 juin 2014, Date de fin: 31 mai 2017,
... behavior of molecular systems. Advancement of these methods is the main objective of this proposal. The applicability of accurate electron correlation methods is limited by the steep increase in the computational cost when the size of the molecular system is increased.In this project a new approach is proposed where the computational cost of the electron correlation part becomes constant with the ...
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1
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TERMINÉ
Hybrid quantum networks for spin coherent technologies (HYSCORE)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,
...etworks.To achieve these ambitious goals, I will exploit and combine the key strengths of different types of quantum information carriers: the robustness of nuclear spins for storage and core computational tasks, the optical interface of electron spins for initializing and reading the nuclear spin registers, and the mobility and coherence of photons for establishing truly long-distance links. Two ...
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1
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TERMINÉ
Coherent ultrafast spectroscopy and manipulation of excitonic Q-bits (CUSMEQ)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,
... background from the optical excitation pulses. Having this technique at hand, the coherent control and the implementation of all-optical quantum gates can be approached. The demonstration of quantum computational operations using individual quantum systems in solid state is the next step towards the realization of a solid state quantum computer. The project will include an advanced training of th ...
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1
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TERMINÉ
Multiscale Modelling of Femtosecond Spin Dynamics (FEMTOSPIN)
Date du début: 1 juin 2012, Date de fin: 31 mai 2015,
...cesses and to make a critical comparison with experimental data. The overall goal of the project is to use this understanding to optimise materials for ultrafast (femtosecond) reversal and to develop computational tools for future materials and device design."
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9
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TERMINÉ
Integrated Roof Wind Energy System (IRWES)
Date du début: 1 mars 2011, Date de fin: 28 févr. 2013,
...wind energy harvesting systems can bring solution of our renewable energy shortage. The Project focuses on bridging knowledge gaps among existing theories of fluid mechanics, wind power generation, computational fluid dynamics, wind tunnel testing, structural design and material engineering. From a multidisciplinary perspective, these studies address a spectrum of topics including skewed flow, geo ...
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1
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TERMINÉ
ENtanglement renormalization and GAuGE Symmetry (ENGAGES)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2013,
...ry limited ability to perform time evolutions. These limitations prevent our complete understanding of LGT.By applying ER directly to the LGT Hamiltonian formulation, Dr. Tagliacozzo will provide new computational tools to override these limitations and gain access to: 1) scaling of the entanglement entropy and non local observables and fidelities, 2) simulations of LGT with either bosonic or ferm ...
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1
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TERMINÉ
A Systems Biology Approach to Elucidate the Yeast Metabolic Network (MRM-Yeast Metabolism)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2010,
... targeted proteomics approach, pioneered in the host group and which I preliminarily developed in the first months of my work. In the context of a well-established collaboration with metabolomics and computational systems biology groups at ETH Zurich, the generated proteomic and phosphoproteomics data on metabolic enzymes will be coupled to quantitative data of the associated mRNA transcripts, met ...
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1
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TERMINÉ
Advanced Turbulence Simulation for Aerodynamic Application Challenges (ATAAC)
Date du début: 1 avr. 2009, Date de fin: 30 juin 2012,
"The ATAAC project aims at improvements to Computational Fluid Dynamics (CFD) methods for aerodynamic flows used in today’s aeronautical industry. The accuracy of these is limited by insufficient capabilities of the turbulence modelling / simulation approaches available, especially at the high Reynolds numbers typical of real-life flows. As LES will not be affordable for such flows in the next 4 d ...
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22
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TERMINÉ
Probabilistic Assessment of the Retention and Transport of Sediments and Associated Pollutants in Rivers (PARTS)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2011,
...ich the fate of each particle can be individually tracked and modelled. Such a form of sediment modelling is still limited by the existing knowledge of the relevant grain scale physics rather than by computational limitations. The oldest but still most difficult questions to answer about river sediments is whether they do or do not move under the action of the flow and when in motion, where do the ...
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1
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TERMINÉ
Design oriented flow distribution optimization of the solid oxide fuel cell stack operating under electric load (HYDROSOFC)
Date du début: 1 oct. 2008, Date de fin: 30 sept. 2011,
...in the scale-up process or even a stack failure at high electric load, high fuel utilization conditions. Efficient and uniform supply of reactants and removal of products was previously studied using computational fluid dynamics (CFD) methods. These methods, although accurate, require significant computing power, computing time and offer limited optimization capabilities. The flow networks modelin ...
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1
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TERMINÉ
Transcription Factor Dynamics in Living Cells at the Single Molecule Level (TF dynamics in vivo)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,
...al describes new state-of-the-art single molecule microscopy methods for studying kinetics and diffusion of TFs in living cells. The proposed experimental techniques will be accompanied by pioneering computational methods for stochastic reaction-diffusion modeling of intracellular kinetics. Only by the concomitant advancement of both methodologies will we gain understanding of how transcription fa ...
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1
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TERMINÉ
Thermal-hydraulics of Innovative Nuclear Systems (THINS)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2015,
For the long-term development of nuclear power, innovative nuclear systems such as Gen-IV reactors and transmutation systems need to be developed for meeting future energy challenges. Thermal-hydraulics is recognized as a key scientific subject in the development of innovative reactor systems. This project is devoted to important crosscutting thermal-hydraulic issues encountered in various innovat ...
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