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17 projets européens trouvés

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 EN COURS 
Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omi ...
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 13

 TERMINÉ 
Cancer, the second most common form of death after cardiovascular disease, is a major European health concern. In 2006, 3.1 million new cases were diagnosed and 1.7 million deaths were attributed to cancer within Europe. The European Commission has a “European Partnership for Action against Cancer” (IP/09/1380) with the aim of reducing the number of cancer cases by 15% by 2020. A key challenge is ...
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 10

 TERMINÉ 

Understanding Klebsiella pneumoniae respiratory infections (U-KARE)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

"Pneumonia is leading cause of death from infection. During infection, microbial presence is monitored by receptors recognizing evolutionary conserved structures. Pathogen recognition is associated with the activation of few regulators and signaling pathways controlling host defence systems. A better understanding of the host-pathogen interaction offers the potential for pharmacological interventi ...
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 1

 TERMINÉ 
Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caus ...
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 15

 TERMINÉ 
Optimal, healthy pregnancy followed by normal birth is the ideal. Caesarean section (CS) doubles the risk of mortality and morbidity (hysterectomy, blood transfusion), and increases the risk of postnatal infection by 5, compared with vaginal birth (WHO Global Survey on Maternal and Perinatal Health). The European Perinatal Health Report (2008) notes “widespread concern” over rising CS rates, which ...
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 11

 TERMINÉ 
"The increasing number of bacteria resistant to all antibiotics and antimicrobials and the virtual lack of antiviral drugs make necessary to develop therapeutics based on new targets/approaches. European-wide-acting sectors must permanently improve their capabilities and capacities to cope with these challenges. Thus, the demand for experts trained to understand infectious diseases in their whole ...
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 11

 TERMINÉ 

Repair of Diabetic Damage by Stromal Cell Administration (REDDSTAR)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines ...
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 10

 TERMINÉ 

Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2016,

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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 31

 TERMINÉ 

Reproductive Biology Early Research Training (REPRO-TRAIN)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The “Reproductive Biology Early Research Training” network (REPRO-TRAIN) aims to provide all the elements required to train the nextgeneration of researchers with the latest skills to solve the current societal problems in male reproductive biology (Andrology). Thedecline in sperm counts and concomitant increase in testicular cancer demands research in this field as an urgent priority.Spermatogene ...
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 8

 TERMINÉ 
Histopathology has traditionally been a low-throughput, labour-intensive technique. Conventional manual annotation of tissue slides requires a pathologist to examine the tissue and cellular components to grade the level of disease progression. However, digital pathology and automated digital image analysis solutions can provide a more rapid solution. In recent years, there has been a rapid uptake ...
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 6

 TERMINÉ 

Non-genetic mechanisms of intrinsic antimicrobial resistance (NONANTIRES)

Date du début: 1 août 2013, Date de fin: 31 juil. 2015,

NONANTIRES is a groundbreaking project to discover alternative ways for controlling the problem of infection treatment failures due to multidrug antimicrobial resistance. Specifically, my efforts will focus on Gram-negative bacterial opportunistic pathogens that exhibit pan-antibiotic, intrinsic resistance. My team has recently uncovered a novel resistance mechanism based on a cooperative behaviou ...
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 1

 TERMINÉ 
CHANCES aims at combining and integrating on-going cohort studies in order to produce evidence on ageing-related health characteristics and determinants in Europe, and their socio-economic implications. 15 cohorts participate, covering populations from 18 EU Member States, 4 associate countries, and 3 additional countries. The combination of these different studies would lead to an integrated appr ...
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 17

 TERMINÉ 

The COMET (Core Outcome Measures in Effectiveness Trials) Initiative (COMET)

Date du début: 1 oct. 2012, Date de fin: 31 déc. 2014,

"Clinical trialists often struggle when trying to choose the outcomes to measure which would be of most use to the patients, practitioners and policy makers who will use their research to help them make decisions. These difficulties are passed on to those producing and reading systematic reviews, many of whom have experienced the frustration of finding that the original researchers either did not ...
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 11

 TERMINÉ 

Apoptosis Modelling for Treatment Decisions in Colorectal Cancer (APO-DECIDE)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2014,

"With the arrival of new colorectal cancer (CRC) therapeutics targeting specific cell signalling pathways, such as anti-EGFR therapy, personalised cancer treatment is at the door step of clinical practise. This progress in drug development contrasts strikingly with current clinical practice, where decision making depends largely on clinical factors such as tumour staging and age of patient, with t ...
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 7

 TERMINÉ 

EUROpean consortium on NEUTralising antibodies using gp41 (EURONEUT-41)

Date du début: 1 janv. 2008, Date de fin: 31 mars 2014,

There is now an increasingly solid body of scientific evidence which demonstrates that the binding of small molecular weight compounds, peptides and antibodies (Abs) to fusion-intermediate conformations of gp41 leads to an inhibition of HIV cell entry. The principal aim of this project is to exploit this information by establishing a platform where gp41-derived vaccine candidates will be designed ...
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 19

 TERMINÉ 

European Network for Genetic and Genomic Epidemiology (ENGAGE)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2012,

"ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a sub ...
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 26

 TERMINÉ 

The mechanisms of cardiovascular risks after low radiation doses (CARDIORISK)

Date du début: 1 févr. 2008, Date de fin: 30 juin 2011,

"Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular dis ...
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 14