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 TERMINÉ 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 TERMINÉ 

Children’s Liver Tumour European Research Network (ChiLTERN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying ...
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 21

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 

EXperimental Computational Hybrid Assessment of Natural Gas pipelines Exposed to Seismic Risk (EXCHANGE-Risk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

EXCHANGE-Risk is an Intersectoral/International Research and Innovation staff exchange scheme between academia and the industry in Europe and North America focusing on mitigating Seismic Risk of buried steel pipeline Networks that are subjected to ground-imposed permanent deformations. It also aims at developing a Decision Support System for the Rapid Pipeline Recovery to minimize the time require ...
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 10

 TERMINÉ 

DOLORisk: Understanding risk factors and determinants for neuropathic pain (DOLORisk)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2019,

Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their int ...
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 14

 TERMINÉ 

Continuous Regional Analysis Device for neonate Lung (CRADL)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

Each year 15 million babies are born prematurely and many suffer from respiratory failure due to immaturity of the lung and lack of control of breathing. Although respiratory support, especially mechanical ventilation, can improve their survival, it also causes severe injury to the vulnerable lung resulting in severe and chronic pulmonary morbidity lasting in to adulthood. Heterogeneity of lung ae ...
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 11

 TERMINÉ 

Human Rights – MUtually Raising excellence (HURMUR)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

The project “HURMUR: Human rights – mutually raising excellence” will decisively expand the world-class research area of human rights in Europe. Tallinn University Law School will develop research excellence of human rights and become involved in global research and regional dissemination networks through specific activities of an outstanding consortium, where two other partners are premier global ...
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 3

 TERMINÉ 

Development and Epilepsy - Strategies for Innovative Research to improve diagnosis, prevention and treatment in children with difficult to treat Epilepsy (DESIRE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 

Enhancing ecoSysteM sERvices mApping for poLicy and Decision mAking (ESMERALDA)

Date du début: 1 févr. 2015, Date de fin: 31 juil. 2018,

Mapping and assessment of ecosystems and their services (ES) are core to the EU Biodiversity (BD) Strategy. They are essential if we are to make informed decisions. Action 5 sets the requirement for an EU-wide knowledge base designed to be: a primary data source for developing Europe’s green infrastructure; resource to identify areas for ecosystem restoration; and, a baseline against which the goa ...
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 25

 TERMINÉ 

Graphene-based disruptive technologies (GrapheneCore1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CS ...
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 158

 TERMINÉ 

Systems medicine of chronic inflammatory bowel disease (SYSMEDIBD)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillat ...
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 13

 TERMINÉ 

Enhancing prediction of tropical Atlantic climate and its impacts (PREFACE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Tropical Atlantic climate recently experienced pronounced shifts of great socio-economic importance. The oceanic changes were largest in the eastern boundary upwelling systems. African countries bordering the Atlantic strongly depend upon their ocean - societal development, fisheries, and tourism. They were strongly affected by these climatic changes and will face important adaptation challenges a ...
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 30

 TERMINÉ 

WELCOME - Wearable Sensing and Smart Cloud Computing for Integrated Care to COPD Patients with Co-morbidities (WELCOME)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Description Innovative solutions for COPD multi-morbid patients To help Chronic Obstructive Pulmonary Disease (COPD) patients with comorbidities and to reduce the burden on our health systems, the WELCOME project aims to create innovative solutions such as an integrated care management tool and a ...
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 13

 TERMINÉ 

Exploring Functional and Developmental Osteoclast Heterogeneity in Health and Disease (EUROCLAST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

Euroclast proposes a research training program on osteoclast biology in the context of osteoclast-driven diseases. Osteoclasts are the complex, multinuclear cells responsible for bone breakdown. Many diseases of osteoclast malfunctioning manifest in bone loss, for example, osteoporosis, cancer-induced bone disease, periodontitis, or rheumatoid arthritis, all conditions set to increase in an ageing ...
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 11

 TERMINÉ 

Responses to coastal climate change: Innovative Strategies for high End Scenarios -Adaptation and Mitigation- (RISES-AM-)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

"Coastal areas concentrate vulnerability to climate change due to high levels of population, economic activity and ecological values. Because of that RISES-AM- addresses the economy-wide impacts of coastal systems to various types of high-end climatic scenarios (including marine and riverine variables). It encompasses analyses from global to local scales across the full range of RCPs and SSPs. It ...
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 12

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

Graphene-Based Revolutions in ICT And Beyond (GRAPHENE)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2016,

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries – from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.Our main scientific and technological objectives in the different tiers of the value chain are to develop material technologies fo ...
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 154

 TERMINÉ 

"Maximising yield of fisheries while balancing ecosystem, economic and social concerns" (MYFISH)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

"The MSY concept was included as a principle in the 2009 Green Paper on the reform of the Common Fisheries Policy (CFP) in accordance with the global imperative to manage fish stocks according to the maximum sustainable yield (MSY). This implies a commitment to direct management of fish stocks towards achieving MSY by 2015. Attaining this goal is complicated by the lack of common agreement on the ...
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 31

 TERMINÉ 

EUROPEAN NETWORK for CANCER research in CHILDREN and ADOLESCENTS (ENCCA)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

"ENCCA aims to establish a durable, European Virtual Institute clinical and translational research in childhood and adolescent cancers that will define and implement an integrated research strategy and will facilitate the necessary investigator-driven clinical trials to introduce the new generation of biologically targeted drugs into standard of care for children and adolescents with cancer. This ...
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 34

 TERMINÉ 

Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing (EpiHealth)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient de ...
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 7

 TERMINÉ 

Understanding chronic pain and improving its treatment (EUROPAIN)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2015,

We will establish an international team of leading researchers and clinicians (EuroPain) to undertake multidisciplinary translational research which will: 1) increase the understanding of chronic pain mechanisms; 2)facilitate the development of novel analgesic drugs; and 3) improve the treatment of chronic pain patients.Nineteen researchers drawn from the London Pain Consortium, the Danish Pain Re ...
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 29

 TERMINÉ 

Ion Transport Proteins in Control of Cancer Cell Behaviour (IonTraC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

"With over 3 million new cases and 1.5 million arising deaths each year in Europe, cancer is a major public health problem with an urgent need for new therapies. This proposal builds upon mounting evidence that ion channels and transporters underlie many of the hallmarks of cancer. Thus, proteins involved in membrane transport, long known as important drug targets in other pathologies (channelopat ...
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 11

 TERMINÉ 

Architecture and roadmap to manage multiple pressures on lagoons (ARCH)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

The ARCH research project “Architecture and roadmap to manage multiple pressures on lagoons” aims to develop participative methodologies in collaboration with policy makers, local authorities and stakeholders to manage the multiple problems affecting lagoons (estuarine coastal areas). These areas represent ecosystems that are very vulnerable for climate change, increasing urbanisation and industri ...
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 12

 TERMINÉ 

Enhanced plant productivity through control of lifespan (CROPLIFE)

Date du début: 1 déc. 2010, Date de fin: 30 juin 2015,

The world-wide demand for primary plant products to be used for food, feed and fuel is increasing dramatically. The foreseen climate changes are expected to have a negative impact on plant productivity in addition. Future agriculture urgently needs new crop plant varieties with enhanced and sustainable productivity. To meet this challenge, “CropLife” focuses on leaf lifespan as a major determinant ...
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 11

 TERMINÉ 

Microbes in Allergy and Autoimmunity Related to the Skin (MAARS)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

"Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know ver ...
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 10

 TERMINÉ 

Socio economic effects of management measures of the future CFP (SOCIOEC)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,

SOCIOEC is an interdisciplinary, European wide project bringing together scientists from several fisheries sciences with industry partners and other key stakeholders to work in an integrated manner on solutions for future fisheries management, that can be implemented at a regional level. The central concept is to provide a mechanism for developing measures that are consistent with the overarching ...
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 26

 TERMINÉ 

Dynamic Molecular Nanostructures (DYNAMOL)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

The ITN DYNAMOL will establish a powerful new approach for the preparation of nanostructures based on dynamic covalent chemistry. This approach combines the advantages of covalent synthesis (robustness of bonds) with those of non-covalent synthesis (error correction, responsiveness) without any of the disadvantages. It therefore has the potential to provide unique solutions for several important c ...
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 13

 TERMINÉ 

Groundwater and dependent Ecosystems: NEw Scientific basIS on climate change and land-use impacts for the update of the EU Groundwater Directive (GENESIS)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2014,

Groundwater resources are facing increasing pressure from consumptive uses (irrigation, water supply, industry) and contamination by diffuse loading (e.g. agriculture) and point sources (e.g. industry). This cause major threat and risks to our most valuable water resource and on ecosystems dependent on groundwater. New information is need on how to better protect groundwaters and groundwater depen ...
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 28

 TERMINÉ 

Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme (ALPHA-MAN)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2014,

Alpha-Mannosidosis is a rare Lysosomal Storage Disorder with a worldwide incidence of about 1:500 000. This orphan and devastating disease is caused by the deficiency of the lysosomal alpha-mannosidase (LAMAN) which is responsible for the intralysosomal degradation of mannosyl linked oligosaccharides. To date no causative treatment for alpha-Mannosidosis is available and since most of the children ...
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 12

 TERMINÉ 

Technet_nano – Transnational network of public clean rooms and research facilities in nanotechnology making accessible innovation resources and services to SMEs in the BSR (Technet_nano)

Date du début: 28 sept. 2011, Date de fin: 27 mars 2014,

Technet_nano sets up a transnational network of public clean rooms and research facilities in micro- and nanotechnology making accessible innovation resources and services to SMEs in the BSR.The problem addressed is that especially SMEs and R&D institutions in branches such as energy, climate or medical technology do not fully exploit their innovation and growth potentials in the field of micro- a ...
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 14

 TERMINÉ 

Climate Induced Changes on the Hydrology of Mediterranean Basins: Reducing Uncertainty and Quantifying Risk through an Integrated Monitoring and Modeling System (CLIMB)

Date du début: 1 janv. 2010, Date de fin: 28 févr. 2014,

"With regard to the objectives specified in ENV-2009.1.1.5.2, modeling capabilities must be improved and appropriate tools developed to advance the capability to assess climate effects on water resources and uses. The project consortium will employ a combination of novel field monitoring concepts, remote sensing techniques, integrated hydrologic (and biophysical) modeling and socioeconomic factor ...
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 21

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

Transparency of Food Pricing (TRANSFOP)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

"The overall objective of this project is to address the key aspects of the food chain both that determine the transmission of price changes from farm to consumer levels, emphasising the role of competition in the intermediate and retail stages of the food chain and the broader regulatory environment in which firms in food supply chains across the EU compete. Given that the characteristics of the ...
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 13

 TERMINÉ 

Multi-level assessment of ocean-climate dynamics: a gateway to interdisciplinary training and analysis (GATEWAYS)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

"GATEWAYS will conduct interdisciplinary climate change research on an ocean regime of regional and global significance: the Agulhas Current off southern Africa. It will provide 15 Early-Stage (ESR) and 3 Experienced Researchers (ER) with extensive multi-level scientific and complementary skills training in (1) processes relevant to climatic developments and projections, (2) efficient organization ...
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 11

 TERMINÉ 

Resolve Chronic Inflammation and Achieve Healthy Aging by Understanding Non-regenerative Repair (RESOLVE)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"RESOLVE has been outlined to better understand the regulatory networks that control the devel-opmental processes in organ repair and to identify mechanisms which cause the termination of regu-lar organ development leading to fibroproliferative wound healing. Fibroproliferative wound healing represents a major pathology in elderly people shifting regular organ development into progressive organ fi ...
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 14

 TERMINÉ 

MOFs as Catalysts and Adsorbents: Discovery and Engineering of Materials for Industrial Applications (MACADEMIA)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2013,

A major challenge facing European industry involves the development of more specific, energy saving processes with less environmental impact. The recent development of Metal Organic Frameworks (MOFs) may prove a major milestone in achieving these goals. MACADEMIA project is an extension to an FP6 STREP (DeSANNS) which highlighted some MOF materials for CO2 capture and storage. It will expand and c ...
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 17

 TERMINÉ 

MERGING ATOMISTIC AND CONTINUUM ANALYSIS OF NANOMETER LENGTH-SCALE METAL-OXIDE SYSTEMS FOR ENERGY AND CATALYSIS APPLICATIONS (MACAN)

Date du début: 1 juin 2009, Date de fin: 31 mai 2013,

The stability of thin films in contact with different materials is a critical issue for a wide range of modern devices, including high-k films in the microelectronics industry, metal electrodes for fuel cells, and nanometer sized particles on oxides for catalysis. Some groups are working on thermodynamic analysis of thin film stability, who correlate relative interface energies with dopant adsorpt ...
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 16

 TERMINÉ 

Forging Identities: The Mobility of Culture in Bronze Age Europe (FORGING IDENTITIES)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

This ITN will continue and enhance the success of a recent RTN ‘The Emergence of European Communities (2-2001-00366)’: Several PhDs have been educated and new knowledge has been unearthed concerning the economic and political foundations of intercultural interaction in Bronze Age Europe – a golden epoch between 3000 and 500 BC with new patterns of social identification, specialised production, co ...
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 7

 TERMINÉ 

REvolutionary Approaches and Devices for Nucleic Acid Analysis (READNA)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

"The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible w ...
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 20

 TERMINÉ 

Model driven Soil Probing, Site Assessment and Evaluation (ModelPROBE)

Date du début: 1 juin 2008, Date de fin: 30 sept. 2012,

Conventional techniques for site characterization are time consuming, cost intensive, and do not support decision making. Therefore, new techniques for step by step site characterization strategy with smart feed back loops are necessary. These will be able to support a future “soil framework directive”. Advanced geophysical site characterization techniques combined with new types of vegetation ana ...
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 17