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 TERMINÉ 

Polymeric ligands for molybdenum and rhenium clusters (PolyMoRe)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2015,

... fully exploit the terrific potential of MeCs, methods will be developed to incorporate them into organic polymers to create novel materials with a plethora of applications that include bioimaging, cancer treatment, LEDs and solar cells. These materials will provide alternatives to expensive and environmentally harmful materials currently in use. Thus PolyMoRe will contribute significantly to the ...
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 1

 TERMINÉ 

Blood test for clinical therapy guidance of non-small cell lung cancer patients (LungCARD)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not presen ...
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 8

 TERMINÉ 

IN-OVO AUTOMATION FOR CANCER DRUG DISCOVERY (OVOMATIC)

Date du début: 1 janv. 2017, Date de fin: 30 juin 2017,

...tion of 6-9 months. It represents a huge obstacle for the pharmaceutical industry, leading to fewer new drugs brought to market each year, and insufficient treatments for severe pathologies such as cancer or orphan diseases. INOVOTION can play a major role in solving this huge societal issue: we have the technology to revolutionize drug discovery by automating in vivo drug evaluation for efficacy ...
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 1

 TERMINÉ 

Amélioration de l'efficaité et de la biodisponibilité des médicaments (Improving Drugs Efficacy and Availability) (IDEA)

Date du début: 31 mai 2009, Date de fin: 29 juin 2013,

...e regulatory authorities since 1995 have poor solubility, poor permeability, or both. The IDEA project aims at overcoming this major bottleneck. All types of diseases will be addressed, although, anticancer drugs exhibit particular challenges during formulation. Cancer is currently the second leading cause of death in Europe and the disease takes a very high human toll. This is particularly true f ...
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 6

 TERMINÉ 

Enabled Media

Date du début: 1 août 2015, Date de fin: 29 févr. 2016,

... Health Organisation shows that around 15% of the world population are disabled, equating to over 1bn people. Disabled adults are 3 times more likely to have heart disease, stroke, diabetes, or cancer than non-disabled adults. They also often have to deal with secondary/ associated conditions (pain, fatigue, depression, weight gain, spasticity, seizures, balance and thermoregulatory problems) r ...
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 2

 TERMINÉ 

Precision Therapies in Lung Squamous Cell Carcinoma (PrecTherLSCC)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,

Lung squamous cell carcinoma (LSCC) represents one third of lung tumours; 550,000 cases are diagnosed annually worldwide (20% occur in Europe). Treatment options for this cancer type are still scarce. Identification of LSCC genetic drivers is thus an essential unmet need for developing novel therapies for this disease.In a stepwise multidisciplinary approach, we will determine if TNIK (Traf-2 and ...
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 1

 TERMINÉ 

Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis (ChondUb)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,

...esis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been eluc ...
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 1

 TERMINÉ 

Feasibility study on Opto-Magnetic Imaging Spectroscopy for cancer screening (OMIS)

Date du début: 1 mars 2016, Date de fin: 31 août 2016,

Cancer is among the leading causes of death in the modern world with over 8 million cancer related deaths globally and over 1 million in the EU. The estimated economic costs of this EU social problem in 2009 was over €120 billion with the healthcare costs at 40% of this amount. Early identification of cancers continues as a key priority to reducing loss of life and subsequent treatment costs. Scr ...
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 1

 TERMINÉ 

Identification of genes and pathways regulated by the HAT activity of MOZ (HAT-MOZ-sphere)

Date du début: 1 sept. 2015, Date de fin: 31 août 2017,

... wide range of new and transferable skills through a variety of multidisciplinary training programs. Relying on the knowledge and expertise of her supervisor and the exceptionally high calibre of the Cancer Research UK Manchester Institute, this project will enable Dr Anne Largeot to achieve her long-term objective of obtaining a leadership position in a competitive European Institute
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 1

 TERMINÉ 

Improving physical dosimetry and developing biologically-relevant metrology for spot-scanned proton therapy beams (ProtonSpotScanMet)

Date du début: 4 sept. 2014, Date de fin: 3 mars 2017,

...n Therapy Centre, and the return host will be University College London, who are currently building a spot scanning proton therapy clinic. Collaborators from IBA Particle Therapy, the UK Institute of Cancer Research and the UK National Physical Laboratory will also be involved.The applicant will be trained in proton therapy dosimetry research techniques, as well as receive clinical training in pro ...
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 1

 TERMINÉ 

The use of genetic profiling to guide prostate cancer targeted screening and cancer care (BARCODE)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,

"Prostate cancer is the commonest solid cancer in men in the European Community. There is evidence for genetic predisposition to the development of prostate cancer and our group has found the largest number of such genetic variants described to date worldwide. The next challenge is to harness these discoveries to advance the clinical care of populations and prostate cancer patients to improve scre ...
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 1

 TERMINÉ 

The interaction and clearance of senescent vascular cells by the innate immune system (ICSIS)

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease. Therefore, the aim of this research is to understand why senescent ...
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 1

 TERMINÉ 

Understanding the functional role of Retinoic Acid Receptor Beta2 in the development of oral cancer (RARBETA2 IN OSCC)

Date du début: 15 oct. 2013, Date de fin: 14 oct. 2015,

The most common cancer in India is oral squamous cell carcinoma (OSCC), a tumour with poor survival whose incidence has also markedly increased in the UK over the past 30 years. There has been much interest in chemoprevention of OSCC, but large clinical trials of agents such as Vitamin A analogues (retinoids) have proved disappointing. One reason is that the function of retinoids in precancerous ...
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 1

 TERMINÉ 

Global Alliance for Chronic Diseases (GACD)

Date du début: 1 janv. 2013, Date de fin: 31 mars 2014,

...ica) to coordinate research activities addressing on a global scale the prevention and treatment of chronic, non-communicable diseases such as cardiovascular diseases, diabetes, respiratory diseases, cancer and mental health. The first coordinated research programme of the GACD focuses on hypertension prevention and control in Low and Middle Income Countries. The specific objectives of the forthco ...
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 1

 TERMINÉ 

Irradiation of model biomolecular nano-systems (RAD-NANO-BIOMOL)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

...um. This represents a major current research challenge for physicists, chemists, and biologists, with important applications in quantifying the effects of radiation exposure, in particular during cancer therapies. A mobile cluster source will be constructed at the Open University (UK) in order to carry out 2-photon ionization experiments which probe the effects of solvated water molecules upon th ...
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 1

 TERMINÉ 

Magnetic Energy Conversion in Fine Nanoparticle Systems (MENCOFINAS)

Date du début: 1 août 2011, Date de fin: 31 juil. 2013,

...nment-friendly nanotechnologies or in biomedicine. Examples include the use of magnetic nanoparticles (MPs) in devices for magnetocaloric refrigeration or for heating in the hyperthermia treatment of cancer. Investing in these areas is imperative if the European Research Area and the European nanotechnologies industry it to gain a worldwide leadership. Essential are scientific developments and als ...
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 1

 TERMINÉ 

The association between type 2 diabetes diagnosis and diabetes medications with risk of cancer (Diabetes and cancer)

Date du début: 1 sept. 2011, Date de fin: 31 août 2013,

Type 2 diabetes and cancer are two chronic diseases that negatively influence the survival of millions of people worldwide. Diabetes has been shown in meta-analyses to be associated with an increased risk of several cancers, but these associations are not yet documented as causal. The evidence for specific diabetes drugs affecting cancer risk is limited, because randomized clinical trials are not ...
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 1

 TERMINÉ 

Breaking Tolerance - Combination of Virotherapy and Immunotherapy for Cancer Treatment (Viral&Immune Therapy)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2013,

... to escape host immune system. Here, we propose to use the chemotherapeutic agent cyclophosphamide to temporally deplete suppressor T cells and recruit new dentritic cell progenitors. Second, to kill cancer cells, we propose to systemically deliver the potent tumour-killing (oncolytic) adenovirus ICOVIR15, which replicates selectively in cancer cells with pRB pathway mutations. In order to favour ...
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 1

 TERMINÉ 

Characterisation of PI3K isoform roles in pancreatic cancerogenesis (PaCa/PI3K)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2014,

...sited classification of PI3Ks.PI3K signalling is altered (constitutively active) and correlated with a poor pronostic in pancreatic adenocarcinoma. Pancreatic adenocarcinoma is one of the most lethal cancers and no chemotherapeutic treatment is currently available for this type of cancer. In this proposal, I will study the isoform-specific role of the signalling enzymes PI3Ks using new unique mous ...
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 1

 TERMINÉ 

Molecular and cellular heterogeneity of tumour stem cells in human glioblastoma (tumourstemcells)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2013,

"Despite the emergence of new targeted therapies, there is still no curative treatment for many human cancers. Through the need for the best combination and solution, a new theory has suggested that cancer is as a stem cell-driven disease and a growing body of evidence has supported this hypothesis.In this context, the applicant proposes to investigate the biological function and complexity of the ...
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 1

 TERMINÉ 

Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below (EpiRadBio)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

Recent epidemiological studies suggest that cancer risk after exposures with doses comparable to the dose limits for occupationally exposed workers may be larger than assumed by ICRP in the derivation of these limits. The value of cancer risk from such exposures and its dependence on tissue, radiation type and individual factors is largely unknown. The innovative approach proposed here combines ep ...
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 23

 TERMINÉ 

Pulmonary Imaging Network (Π-NET)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2014,

...dies. The main research activity line aims at applying MRI based techniques for diagnosis (human and preclinical activities) and treatment (only preclinical) monitoring of lung diseases (COPD, lung cancer, cystic fibrosis, asthma), without excluding the possibilities that other imaging techniques (nuclear, CT and optical imaging) and molecular approaches (including molecular imaging and metabolomi ...
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 11

 TERMINÉ 

New bioactive agents based on natural products (NABIO)

Date du début: 1 juin 2010, Date de fin: 31 mai 2012,

"More than 1 in 3 people in the EU will develop cancer during their lifetime. Despite huge investment, insufficient new bioactive molecules are emerging, and there is urgent need for a different approach to research in this area. Drawing inspiration from Nature, the Fellow will investigate natural products with anticancer potential. The objective of the IEF is to support the career development of ...
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 1

 TERMINÉ 

Quantum chemical and combined quantum mechanical/molecular mechanical (QM/MM) modelling of oestrogen biosynthesis and metabolism (OestroMetab)

Date du début: 1 oct. 2009, Date de fin: 29 sept. 2012,

...nifold role in the correct functioning of the human body, which is especially pronounced in the case of women. Prolonged exposure to oestrogen has been shown to increase the risk of developing breast cancer due to the cumulative effect of toxic metabolites formed from oestrogens. State-of-the-art treatment of breast cancer involves inhibition of aromatase, the enzyme responsible for the last step ...
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 1

 TERMINÉ 

Transgenic models of mammalian meiotic exit (Perry/mII/tg)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

...xit in mammals. Ignorance about meiotic exit can and must be addressed; the mechanisms that underlie the period of meiotic exit impact all changes in cellular potency, including those predisposing to cancer and rationales for deriving induced pluripotent stem (iPS) cells and the emergent field of regenerative medicine in general. The present proposal addresses this gap in our understanding in mice ...
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 1

 TERMINÉ 

Particle Training Network for European Radiotherapy (PARTNER)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

...g field of hadron therapy. This is an interdisciplinary, multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of ion therapy in cancer treatment, and promote clinical, biological and technical developments at a pan-European level, for the benefit of all European inhabitants. This need has particular urgency since two particle ...
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 10

 TERMINÉ 

Oral Off-patent Oncology Drugs for Kids (03K)

Date du début: 1 sept. 2008, Date de fin: 31 août 2011,

"There is an urgent need for appropriate oral formulations of anticancer drugs for the treatment of paediatric malignancies in children. The goal of the O3K consortium is to develop oral liquid formulations of Cyclophosphamide and Temozolomide, important chemotherapeutics which have been identified in the list of paediatric needs by EMEA (EMEA/197972/2007). Both off-patent drugs are widely used or ...
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 9

 TERMINÉ 

Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes (THESEUS)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, th ...
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 3

 TERMINÉ 

EUBET

Date du début: 1 sept. 2016, Date de fin: 31 août 2018,

Bromangymnasiet in Hudiksvall is situated in a region of very high unemployment, among the young it is the highest percentage in the country (25 %). Our school has the task and mission to develop an intercultural teaching practice supported by inclusive, innovative methods and entrepreneurship to achieve a more entrepreneurial learning for the benefits of our students. For some years now, we have ...
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 62

 TERMINÉ 

iManageCancer - Empowering patients and strengthening self-management in cancer diseases (iManageCancer)

Date du début: 1 févr. 2015, Date de fin: 31 juil. 2018,

Chronic cancer treatment places new demands on patients and families to manage their own care. The iManageCancer project will support this challenge and provide a cancer disease self-management platform designed according to the specific needs of patient groups and focusing on the wellbeing of the cancer patient with special emphasis on psycho-emotional evaluation and self-motivated goals. The pla ...
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 11

 TERMINÉ 

Design Principles of Microtubule Cytoskeleton Architectures during Cell Division (SPINDLEDESIGN)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,

The microtubule cytoskeleton provides an intracellular coordinate system and a mechanical scaffold for a multitude of essential cellular functions. The design principles underlying the dynamic organisation and function of the microtubule cytoskeleton are not understood. Using an in vitro reconstitution approach, we will determine the rules that govern which combination of mechano-chemical elements ...
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 2

 TERMINÉ 

Vivre et travailler en Europe

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

Our goal is to provide students with additional foreign language skills in their professional field, but also open-mindedness and adaptability towards foreign countries in the perspective of living and working abroad.The 14 students concerned are in their junior year in a vocational high-school, and they will go abroad for 4 weeks (from May 29th to June 23th 2017).The teachers who are concerned a ...
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 11

 TERMINÉ 

Targeting RAS oncogene addiction (RASTARGET)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

Lung cancer is the most common type of malignant tumour worldwide and the leading cause of cancer-related death (335,000 deaths per year in Europe). The KRAS oncogene is frequently activated by point mutation in human lung cancer and mutations in the RAS family oncogenes are responsible for driving some 20% of all human malignancies. Most cell lines from RAS mutant tumours remain “oncogene addicte ...
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 2

 TERMINÉ 

ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN (ATMINDDR)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2018,

ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand bre ...
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 2

 TERMINÉ 

QUantitative Imaging in Cancer: CONnecting CEllular Processes with Therapy (QUIC-CONCEPT)

Date du début: 1 sept. 2011, Date de fin: 31 déc. 2017,

...nt that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce ...
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 26

 TERMINÉ 

MAL: an actin-regulated SRF transcriptional coactivator (ACTINONSRF)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

MAL: an actin-regulated SRF transcriptional coactivatorRecent years have seen a revitalised interest in the role of actin in nuclear processes, but the molecular mechanisms involved remain largely unexplored. We will elucidate the molecular basis for the actin-based control of the SRF transcriptional coactivator, MAL. SRF controls transcription through two families of coactivators, the actin-bindi ...
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 2

 TERMINÉ 

The impact of chromosomal instability on health: Molecular causes and consequences of aneuploidy (PLOIDYNET)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Aneuploidy, an abnormal number of chromosomes, is a hallmark of cancer cells, affecting the majority of all human tumours. Aneuploidy arises when errors occur during mitosis, as the duplicated chromosomes are distributed between the two new daughter cells. Paradoxically, aneuploidy appears to have detrimental consequences for the physiology of untransformed cells in vitro, inhibiting rather than s ...
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 14

 TERMINÉ 

Cross-species characterisation of CD8alpha+ dendritic cells and their role in immune regulation (DCSUBSET)

Date du début: 1 sept. 2011, Date de fin: 31 août 2017,

...8alpha+ DC equivalents in humans. The results from this proposal will illuminate the function of CD8alpha+ DC across species and open the door for using this intriguing DC subset in immunotherapy of cancer, infectious and autoimmune diseases.
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 2

 TERMINÉ 

Investigating eukaryotic replisome dynamics at the single molecule level (SMI REP)

Date du début: 1 août 2015, Date de fin: 31 juil. 2017,

For cells to reproduce, an accurate duplicate of the genome must be created. This is no small task. The genetic information stored in each cell consists of ~6 billion pairs of nucleobases (base pairs, bp) assembled as a polymer 2 metres long and 2 nanometres in diameter, with the structural form of a double helix. For a mammalian cell to divide, this deoxyribonucleic acid (DNA) must be copied in a ...
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 2

 TERMINÉ 

Vivre et travailler en Europe

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

Our goal is to provide students with additional foreign language skills in their professional field, but also open-mindedness and adaptability towards foreign countries in the perspective of living and working abroad. The 15 students concerned are in their junior year in a vocational high-school, and they will go abroad for 4 weeks (from May 29th to June 25th 2016). The teachers who are concerned ...
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 10