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33 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Zoonotic Anticipation and Preparedness Initiative (ZAPI)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Emerging infectious diseases are occurring at increasing frequency in Europe and other regions of the world, having profound impacts on public and/or veterinary health as well as disruptive effects on sector, regional or even global economy. The predominantly zoonotic nature of emerging pathogens calls for a One Health approach uniting the human medical and veterinary fields, dedicated to swiftly ...
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 21

 TERMINÉ 

Activation and Regulation of the NLRP3 Inflammasome (InflammAct)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The innate immune system protects the host from infections, detects and repairs tissue damage and functions to maintain tissue homeostasis. Several families of signaling receptors can recognize microbial substances or altered host molecules and orchestrate a coordinated inflammatory response. Inflammasomes are signaling platforms that control proteolytic activation of highly proinflammatory cytoki ...
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 1

 TERMINÉ 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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 27

 TERMINÉ 

The other side of optogenetics: multicolored genetically encoded hybrid voltage sensors (GEVOS) for ultrafast membrane potential measurements in cortical microcircuits (MULTIGEVOS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Optogenetics are used to activate or silence specific sets of neurons, intracellular signaling pathways, or to examine brain structure at an unprecedented detail. The only optogenetic approach lagging behind all others is the genetically encoded optical monitoring of multi-neuronal activity at a time resolution of single action potentials. Such ultrafast (
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 1

 TERMINÉ 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
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 12

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Consortium on Organ Preservation in Europe (COPE)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
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 16

 TERMINÉ 

European stem cell consortium for neural cell replacement, reprogramming and functional brain repair (Neurostemcellrepair)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neurostemcellrepair aims at taking human stem cells through the final steps toward clinical application in cell replacement therapy for neurological disorders. PD will be taken as the prototypical disease because stem cell therapy is now close to clinical translation. Moreover, we will tackle next generation issues pertaining to stem cells at a basic level and develop new approaches and novel cell ...
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 13

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury (MIP-DILI)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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 29

 TERMINÉ 

European Bank for induced pluripotent Stem Cells (EBISC)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cos ...
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 30

 TERMINÉ 

Patient-centered palliative care pathways in advanced cancer and chronic disease (INSUP-C)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Integrated delivery systems of care, e.g. networks of health organizations and professionals who work together to coordinate services to meet their patients’ needs, are an important way of linking fragmented services and maximizing system efficiency and seamlessness of patient transition. Research increasingly shows that patients with advanced cancer and advanced chronic disease are treated well ...
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 11

 TERMINÉ 

Quantitative Large Scale Proteomics of Lysosomal Storage Disease (Storage Proteomics)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Lysosomal storage diseases (LSD) are a group of ~ 50 genetic disorders, which mainly affect children. LSDs are clinically heterogeneous but are frequently dominated by progressive neurologic deterioration. Most patients pass away after years of lingering illness. In general, the molecular pathogenesis of LSDs is still poorly understood. To gain insight into disease mechanisms the project investiga ...
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 1

 TERMINÉ 

Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure (Panacreas)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

Pancreatic ductal adenocarcinoma (PDAC) causes 34000 deaths in the EU every year. Conventional cancer treatments have close to no impact on this disease. As a result, almost all patients diagnosed with PDAC develop metastases and eventually die. Given this poor outlook, the search for new therapeutics is mandatory. These will have to target relevant cancer pathways and be designed based on the ava ...
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 12

 TERMINÉ 

European Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS (EuroCoord)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
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 26

 TERMINÉ 

Stem Cells for Relevant Efficient Extended and Normalized Toxicology (SCR&TOX)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

In the development of products for use by humans it is vital to identify compounds with toxic properties at an early stage of their development, to avoid spending time and resource on unsuitable and potentially unsafe candidate products. Human pluripotent stem cell lines offer a unique opportunity to develop a wide variety of human cell-based test systems because they may be expanded indefinitely ...
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 16

 TERMINÉ 

Epilepsy Pharmacogenomics: delivering biomarkers for clinical use (EpiPGX)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The purpose of the project is to identify genome-based biomarkers for use in clinical practice to individualise treatment of epilepsy, and stratify patients for clinical trials, aiming to avoid chronicity, prevent relapse and reduce adverse drug reactions (ADRs).The need for improved treatments in epilepsy is undoubted. Epilepsy is affects 50,000,000 people of all ages worldwide. Epilepsy is serio ...
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 15

 TERMINÉ 

Infectious triggers of chronic autoimmunity (INTRICATE)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the ...
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 13

 TERMINÉ 

Helminth-induced regulatory mechanisms that prevent the onset of diabetes (HELMINTH & DIABETES)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

In Europe >33 million people suffer from diabetes, a chronic disease associated with long-term pathology representing one of the biggest cost factors for the health care system. The ultimate goal of this proposal is to develop a novel immunomodulatory diabetes therapy by identifying parasitic worm (helminth) regulatory mechanisms which protect against autoimmune diseases. The applicants’ previous ...
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 1

 TERMINÉ 

IMplementation of quality indicators in PAlliative Care sTudy (IMPACT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

"New knowledge is not necessarily readily applied in medicine, even when there is evidence of its effectiveness. As a result of the gap between knowing and doing, policy makers, professional care providers, patients and their families have benefited too little from new developments. Implementation research has developed models for stepwise implementation but it is still unclear which strategies ar ...
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 14

 TERMINÉ 

"CATO - CBRN crisis management: Architecture, Technologies and Operational Procedures" (CATO)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

"CATO proposes to develop a comprehensive Open Toolbox for dealing with CBRN crises due to terrorist attacks using non-conventional weapons or on facilities with CBRN material. CATO will:• combine CBRN knowledge, planning & response know-how, DSS building blocks and dedicated models and algorithms• enable the development of specific holistic CBRN-DSS• cover the entire CBRN disaster life cycle from ...
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 28

 TERMINÉ 

Disaster Training Curriculum (DITAC)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The EU aims to consolidate and enhance its disaster response capacity by creating a European Emergency Response Center. This institution should be complimented by a standardised European training curriculum for professional crisis response.A European multi-disciplinary team of experts is collaborating to develop a standardised curriculum for international crises management hereby referred to as DI ...
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 13

 TERMINÉ 

Access to Opioid Medication in Europe (ATOME)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,

"Medicines derived from opium are very valuable in medicine practice & therefore regarded as essential medicines. However, they are generally not readily available for patients who are in need of them for medical reasons. It is estimated that over 80% of the world's population is inadequately treated, because opioid (pain relieving) medicines have been categorized as ""controlled substances"", du ...
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 11

 TERMINÉ 

Integration of Chikungunya research (ICRES)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,

Since 2005 Chikungunya fever has affected millions of people producing a high fever and a debilitating arthralgia which can persist for months and progress to chronic arthritis. Chikungunya virus has been associated with periodic outbreaks of human disease and is spread by mosquitoes. The current epidemic rose to prominence in 2005/6 following infection of >250,000 people on La Réunion. The virus ...
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 15

 TERMINÉ 

Cytosolic recognition of foreign nucleic acids: Molecular and functional characterization of AIM2, a central player in DNA-triggered inflammasome activation (AIM2 INFLAMMASOME)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,

Host cytokines, chemokines and type I IFNs are critical effectors of the innate immune response to viral and bacterial pathogens. Several classes of germ-line encoded pattern recognition receptors have been identified, which sense non-self nucleic acids and trigger these responses. Recently NLRP-3, a member of the NOD-like receptor (NLR) family, has been shown to sense endogenous danger signals, e ...
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 1

 TERMINÉ 

Paving the Way for Future Emerging DNA-based Technologies: Computer-Aided Design and Manufacturing of DNA libraries (CADMAD)

Date du début: 1 févr. 2011, Date de fin: 31 oct. 2014,

CADMAD aims to make a foundational breakthrough in the way computers and computer-aided design and manufacturing is employed in DNA-based research and development, making a radically new use of information technologies in biology and biotechnology.Biology and biotechnology research involves "DNA programming", which is akin to computer programming. Researchers modify and combine DNA of interest in ...
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 12

 TERMINÉ 

Enhanced Protective Immunity Against Filariasis (E PIAF)

Date du début: 1 mars 2010, Date de fin: 31 août 2014,

"Filarial infections remain a major public health problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reac ...
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 11

 TERMINÉ 

European Research Ethics Committees’ Network (EURECNET)

Date du début: 1 mars 2011, Date de fin: 31 août 2014,

EURECNET is a network that brings together national REC associations, networks or comparable initiatives but also other bodies relevant in the field of research involving human participants like National Ethics Councils and the European Commission’s ethical review system. Such a network forms the infrastructural basis to promote awareness of specific working practices of RECs across Europe, to enh ...
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 22

 TERMINÉ 

Investigation of Beta-Amyloid Peptide Effects On Mitochondria Protein Homeostasis: From Pathogenesis to Therapy of Alzheimer Disease (MITOABETA)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,

"Beta-amyloid peptide, a component of senile plaques and generated by proteolytic cleavage of the amyloid precursor protein (APP), is a key factor in the pathogenesis of Alzheimer disease (AD). Beta-amyloid peptide has been shown to influence negatively some important mitochondrial activities such as reducing the efficiency of ATP-production via oxidative phosphorylation, enhancing mitochondrial R ...
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 1

 TERMINÉ 

Genomic variations underlying common behavior diseases and cognition trait in human populations (ADAMS)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,

"The subject of the proposal is the search and analysis of genomic variations underlying Alzheimer's disease (AD), alcoholism and schizophrenia – wide-spread diseases in human populations. Schizophrenia and alcoholism are common forms of behavior pathology and disability in adult life. AD is a most common form of dementia in human populations. Though the genomic variations presumably associated wi ...
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 12