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The emergence of a gastrointestinal tract within the body cavity is one of the major innovations in animal evolution allowing the transition from an intra- to an extracellular mode of digestion. With this emergence came the opportunity for infectious agents to exploit this intestinal ecosystem for their own transmission. Gut-bearing organisms therefore evolved complex mechanisms to defend themselv ...

"Nuclear receptors (NR) constitute a large transcription factor (TF) family with ~50 NRs identified in human or mouse. NRs have crucial roles in multiple tissues and biological processes. Consequently, misregulation of NR gene expression has been linked to several severe pathologies including cancer and neurodegenerative diseases. Despite their pathological importance, the core NR gene regulatory ...