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Visualizing cell maintenance: Chemical tools to investigate the microenvironments of misfolded proteins (VisQC)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2018,
The capacity of the cell to maintain protein quality and function diminishes upon aging and disease. Genetic mutations may result in protein malfunction or structural defects due to an alternation of an essential amino acid. The cell has evolved many mechanisms to handle misfolded proteins; some proteins are refolded by molecular chaperones while others are targeted for degradation by the ubiquiti ...
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