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A pharmacogenomic approach to coumarin anticoagulant therapy (EU-PACT)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,

"The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumari ...
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