9 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
New experimental therapeutic approaches for Parkinson’s disease by direct DA neuronal reprogramming (REPROPARK)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
Neurodegenerative diseases cause a significant burden on the elderly population in Europe. Parkinson’s disease (PD) affects 1.2 million people in Europe and with the increasing life expectancy this number will rise, putting more pressure on health care. Treatment of PD is only symptomatic, and therefore, there is an urgent need for more efficient therapies. Degeneration of mesencephalic DA neurons ...
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2
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TERMINÉ
LEGumes for the Agriculture of TOmorrow (LEGATO)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
The project has been conceived to promote the culture of grain legumes in Europe by identifying priority issues currently limiting grain legume cultivation and devising solutions in term of novel varietal development, culture practices, and food uses. LEGATO will develop tools and resources to enable state of the art breeding methodology and to exploit fully the breadth of genetic resources avail ...
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32
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TERMINÉ
Immunostimulatory Agonist antibodies for Cancer Therapy (IACT)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,
...cer type and treatment regimen have been selected to approximate pre-clinical settings in which striking therapeutic impact with agonist IS-Abs has been obtained. These studies will involve extensive analysis of efficacy-related biomarkers by means of validated assays, not only in blood samples, but also in the most relevant compartment: the tumor microenvironment. While our state-of-the-art agoni ...
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11
Participants partenaires
TERMINÉ
The role of miRNAs in KRAS-driven Non-Small Cell Lung Cancer (KRASmiR)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
Lung cancer is the leading cause of death by cancer in Europe. Non-small cell lung cancer (NSCLC) represents about 80% of total lung cancers. KRAS is the most commonly mutated oncogene in NSCLC, found in over 20% of patients. Since KRAS mutations are directly responsible for NSCLC, KRAS represents a relevant target to prevent NSCLC development. Yet, efforts to develop therapeutic inhibitors have f ...
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1
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TERMINÉ
"From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV" (BRAINVECTORS)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
"BRAINVECTORS aims devising new gene therapy(GT)-based treatments for Parkinson’s and other neurodegenerative diseases, in substitution of current systemic treatments, by delivering neurotrophic factors (GDNF) into the CNS with new vectors derived from adeno-associated (AAV), canine adenoviruses (CAV) and lentiviruses (LV) with inducible gene expression.Although AAV, CAV and LVV are considered acc ...
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12
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TERMINÉ
Role of DNA methylation in the regulation of lincRNAs in Hematological Malignancies (LincMHeM)
Date du début: 1 sept. 2013, Date de fin: 31 août 2016,
"Traditionally, cancer researchers have focused their best efforts on studying the genetic alterations affecting the coding genes. Subsequently, it was observed that in addition to genetic alterations, epigenetic alterations affecting coding genes play an important role in tumor development. In the last decade, largely due to the ability to sequence the human genome and the observation that much o ...
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1
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TERMINÉ
NEW ADVANCED VACCINES IN CHRONIC HEPATITIS B (NAVICHEB)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,
"Despite effective vaccines, hepatitis B virus (HBV) infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for development of hepatocellular carcinoma (HCC). A new and efficient treatment against chronic infection and HCC is strongly needed, and therefore it is important to understand HBV replication ...
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1
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TERMINÉ
The roles of juvenile NMDA receptors in synapse maturation and elimination and their association with cognition (NMDAR-synprun)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
The aim of the project is to understand how the NMDA receptor subunit NR3A is involved in selective synapse elimination (“pruning”) during development and how the abnormal expression of NR3A found in mental disorders such as Schizophrenia, Alzheimer´s disease and Huntington correlates with the reduction of functional synapses and deficits in the cognitive function. Importantly, the Host lab has al ...
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1
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TERMINÉ
Dietitians ensuring education, teaching and professional quality
Date du début: 1 oct. 2010,
The Thematic Network "Dietitians Improving Education and Training Standards" (2006-09) successfully published first cycle competences, influenced education policy change and increased web-based and innovative communication between higher education (HE) and the dietetic profession. But to effectively contribute to policies and practices averting the European health crisis (WHO, 2007) and poor nutri ...
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