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16 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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 11

 TERMINÉ 

New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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 20

 TERMINÉ 

Computational Design of Highly Active Biocatalysts of Interest in the Chemical Industry (CompBiocatDesign)

Date du début: 1 mars 2013, Date de fin: 31 août 2016,

Developing new enzymes for catalyzing non natural reactions is a grand challenge for obtaining more efficient synthetic strategies for chemical industry as well as building complex molecules under enantioselective control with potential applications in medicine. Given the high specificity of natural enzymes for their substrates, new techniques are necessary for redesigning natural enzymes to perfo ...
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 2

 TERMINÉ 

Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function (ProProteinRegulation)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that ...
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 2

 TERMINÉ 

Study of the Determinants of Heterochromatin Formation and Maintenance (HETCHROMPROJECT)

Date du début: 1 juin 2011, Date de fin: 31 mai 2015,

Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also im ...
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 2

 TERMINÉ 

Peptide Dendrimers - A Chemical Platform for Functional Diversity (Peptide Dendrimers)

Date du début: 13 juin 2011, Date de fin: 12 juin 2014,

Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising ...
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 2

 TERMINÉ 

Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategie ...
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 7

 TERMINÉ 

Ligand Engineering for Pauson-Khand Reactions (LE-PKR)

Date du début: 1 sept. 2011, Date de fin: 30 nov. 2013,

"This project is centered on several technological developments around the intermolecular Pauson-Khand reaction, a cobalt catalyzed multicomponent cycloaddition with an unexploited potential to streamline the synthesis of complex organic molecules. The first aim is to find new ligands for the cobalt catalyzed intermolecular Pauson-Khand reaction. A ligand accelerated version of this transformation ...
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 2

 TERMINÉ 

"Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity" (NIMBL)

Date du début: 1 juin 2010, Date de fin: 30 nov. 2013,

"Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL condition ...
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 10

 TERMINÉ 

Epigenetic control of chromatin structure - Solving an intertwined puzzle with a specialized coarse-grained model (EPICHROMATIN)

Date du début: 15 sept. 2011, Date de fin: 14 sept. 2013,

"This project will develop a highly sophisticated coarse-grained model of chromatin fibers from precise all-atom simulations of dinucleosomes and DNA segments. The purpose of the proposed project is to enhance our understanding of the mechanism by which different patterns of epigenetic modifications (of DNA and histone proteins) interact with each other to control the structure of the chromatin fi ...
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 2

 TERMINÉ 

Scalable Software Services for Life Science (ScalaLife)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

Life Science is developing into one of the largest e- Infrastructure users in Europe, in part due to the ever-growing amount of biological data. Modern drug design typically includes both sequence bioinformatics, in silico virtual screening, and free energy calculations, e.g. of drug binding. This development will accelerate tremendously, and puts high demands on simulation software and support se ...
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 6

 TERMINÉ 

Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies (INFLA-CARE)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

Epidemiological and experimental evidence supports a link between chronic inflammation and cancer and indicates a role for inflammatory cells in the initiation, progression and metastasis of malignancy. The objective of the collaborative integrated project INFLA-CARE is to structure a European collective of scientific and technological excellence in the field of ‘Inflammation & Cancer’ which will ...
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 22

 TERMINÉ 

Incorporating flexibility into protein-ligand docking (IFLPD)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2012,

"One of the major goals of current drug discovery methods is the correct treatment of the flexibility of the receptor (i.e., protein) in small ligand docking. Computer-aided drug discovery through ligand docking-based virtual screening is already a key component in the lengthy and costly process of developing new drugs not only for academy but also for the pharmaceutical industries. In this propos ...
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 2

 TERMINÉ 

Analysis of the pathological implications of the abnormal accumulation of glycogen in specific cell types (MGS and disease)

Date du début: 1 juil. 2010, Date de fin: 13 juil. 2012,

Glucose is stored in specialized tissues (mainly liver and muscle) in the form of a branched polymer called glycogen. Glycogen Synthase is the only enzyme able to catalyze this polymerization and its two isoforms (LGS and MGS) are mainly expressed in liver and in muscle, respectively. However, MGS is also expressed in all other tissues, regardless of their limited capacity to produce Glycogen. MGS ...
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 2

 TERMINÉ 

Intestinal stem cells and their role in colorectal cancer progression (CSC program)

Date du début: 1 juin 2010, Date de fin: 31 mai 2012,

Constitutive activation of the Wnt pathway is the key step for initiation of colorectal cancer (CRC). Wnt signaling also plays an essential role in the maintenance of intestinal stem cells (ISCs). In addition, acquisition of a constitutive crypt stem/progenitor phenotype represents the first step towards malignancy. The identification of the Wnt target gene Lgr5 as a marker for ISCs and the findin ...
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 2

 TERMINÉ 

Cellular and structural determinants of amyloid toxicity (Amyloid Hot Spots)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2012,

Neurodegenerative disorders such as Alzehimer´s or Parkinson´s affect millions of people in Europe and are linked to the misfolding and aggregation of proteins in the form of amyloid fibrils. The molecular pathways of amyloid aggregation are complex and poorly understood, and involve the population of oligomeric intermediates before fibrils form. Little is known about the role in vivo of amyloid i ...
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 2