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29 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Blood regeneration: de novo development of human hematopoietic stem cells (DENOVOHSC)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Hematopoietic stem cells (HSC) are used in clinical therapies for leukemia and blood-related genetic disorders. Whereasthe number of patients requiring treatment continues to increase, HSC transplantations are limited due to insufficientpatient-matched donor HSCs. The current challenge is to create more matched HSCs. As evidenced by the Nobel Prizeaward this year, reprogramming of somatic cells to ...
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 1

 TERMINÉ 

Adding Another Dimension – Arrays of 3D Bio-Responsive Materials (ADREEM)

Date du début: 1 nov. 2014, Date de fin: 31 oct. 2019,

This proposal is focused in the areas of chemical medicine and chemical biology with the key drivers being the discovery and development of new materials that have practical functionality and application. The project will enable the fabrication of thousands of three-dimensional “smart-polymers” that will allow: (i). The precise and controlled release of drugs upon the addition of either a small mo ...
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 1

 TERMINÉ 

Vascular remodelling and miRNA therapeutics (VASCMIR)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The central hypothesis of VascmiR is that microRNAs (miRs) fundamentally control pathological remodelling of the vasculature. The complexity of vascular bed heterogeneity and subsequent response to injury, the potential importance of miRNA in vascular pathology and the paucity in knowledge relating to many facets of miRNA function in the vessel wall including target pathways, mechanistic features ...
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 2

 TERMINÉ 

Engineering life: ideas, practices and promises (ENLIFE)

Date du début: 1 sept. 2014, Date de fin: 28 févr. 2019,

The emerging field of synthetic biology promises to engineer the living world. This is potentially extremely contentious, so scholars from the social sciences and humanities have been incorporated into synthetic biology research programmes from the outset. The ENLIFE project’s distinctive contribution will be to study both the engineering of biology and the role of social scientists within this. I ...
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 2

 TERMINÉ 

New Catalytic Reactions and Exchange Pathways: Delivering Versatile and Reliable Arylation (ARYLATOR)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

This proposal details the mechanism-based discovery of ground-breaking new catalyst systems for a broad range of arylation processes that will be of immediate and long-lasting utility to the pharmaceutical, agrochemical, and materials chemistry industries. These industries have become highly dependent on coupling technologies employing homogeneous late transition metal catalysis and this reliance ...
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 1

 TERMINÉ 

A Total Photon Camera for Molecular Imaging of Live Cells (TOTALPHOTON)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"How can we construct a high-resolution camera capable of imaging the time-of-arrival, polarisation and wavelength of each of the maximal 10Gphoton/s emitted from a labelled, biological cell?Such a measurement would capture the complete information available in the optical signal, and significantly enhance our ability to observe the organisation, movement and interactions of cellular components at ...
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 1

 TERMINÉ 

'Orbital molecules' - self-organised states for orbitronics (ORBITMOL)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

‘Orbital molecules’ are made up of coupled orbital states on several metal ions within an orbitally-ordered (and sometimes also charge-ordered) solid such as a transition metal oxide. Spin-singlet dimers (a weak metal-metal bond) are known in several materials, but recent discoveries of more exotic species such as 18-electron heptamers in AlV2O4 and 3-atom trimerons in magnetite (Fe3O4) have shown ...
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 1

 TERMINÉ 

The Physics of Active Particle Suspensions (PHYSAPS)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

...eria can have a viscosity that is lower than that of the suspending liquid. There is yet no gener- ally accepted statistical mechanics of active matter, where the absence of detailed balance means that small differences in microscopic dynamics can in principle lead to very different macroscopic behaviour. Moreover, there is no a priori reason to believe that a reduced description in terms of just ...
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 1

 TERMINÉ 

Wall-crossing and Birational Geometry (WALLXBIRGEOM)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

We will use modern techniques in algebraic geometry, originating from string theory and mirror symmetry, to study fundamental problems of classical flavour. More concretely, we apply wall-crossing in the derived category to the birational geometry of moduli spaces.Bridgeland stability is a notion of stability for complexes in the derived category. Wall-crossing describes how moduli spaces of sta ...
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 1

 TERMINÉ 

Beyond structure: integrated computational and experimental approach to Ensemble-Based Drug Design (EBDD)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Although protein dynamics plays an essential role in function, it is rarely considered explicitly in current structure-based approaches to drug design. Here I propose the computer-aided design of ligands by modulation of protein dynamics, or equivalently, protein structural ensembles. The detailed understanding of ligand-induced perturbations of protein dynamics that will result from this study i ...
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 1

 TERMINÉ 

Transmembrane Molecular Machines (TRANSPORET)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical dev ...
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 2

 TERMINÉ 

Evaluation Practices in Financial Markets (EPIFM)

Date du début: 1 sept. 2012, Date de fin: 31 août 2018,

EPIFM will be a social-science (rather than, as conventionally, an economic) investigation, by a team bridging science and technology studies (STS), sociology and politics, of how professional participants in financial markets evaluate financial instruments such as shares and bonds. These evaluation practices are crucial to the operation of financial markets (they help determine the activities to ...
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 3

 TERMINÉ 

Combinatorial methods in noncommutative ring theory (COIMBRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

As noted by T Y Lam in his book, A first course in noncommutative rings, noncommutative ring theory is a fertile meeting ground for group theory (group rings), representation theory (modules), functional analysis (operator algebras), Lie theory (enveloping algebras), algebraic geometry (finitely generated algebras, differential operators), noncommutative algebraic geometry (graded domains), arithm ...
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 1

 TERMINÉ 

Characterising the interstellar medium of bright, lensed, star-forming galaxies across cosmic time (COSMICISM)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

The physical conditions of molecular gas in galaxies, and the impact of star formation and AGN on these conditions and on the emergent stellar IMF, are overarching themes in astrophysics. We are entering an era where numerical simulations of turbulent molecular gas can be informed and constrained by observations of such gas. I propose to investigate, theoretically and observationally, the impact o ...
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 2

 TERMINÉ 

Genetic and Epigenetic Determinants of Paget's Disease of bone (GENEPAD)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

Paget’s disease of bone (PDB) is a common disease characterised by focal areas of increased bone turnover leading to symptoms of bone pain, deformity, osteoarthritis and other complications. Genetic factors play an important role in PDB and mutations in SQSTM1 gene are responsible for ~10% of PDB cases with high penetrance. We have recently identified seven additional susceptibility loci for PDB u ...
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 1

 TERMINÉ 

Dissection of centromeric chromatin and components: A biosynthetic approach (BIOSYNCEN)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The centromere is one of the most important chromosomal elements. It is required for proper chromosome segregation in mitosis and meiosis and readily recognizable as the primary constriction of mitotic chromosomes. Proper centromere function is essential to ensure genome stability; therefore understanding centromere identity is directly relevant to cancer biology and gene therapy. How centromeres ...
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 2

 TERMINÉ 

Rule-Based Modelling (RULE)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The purpose of this research programme is to contribute to the solution of a major problem in today’s systems biology: namely, the difficulty to bring mechanistic modelling to bear on full scale systems. Statistical, and experimental techniques have scaled up considerably in the last two decades. Mechanistic modelling, on the other hand, is still confined in much smaller scales. Witness the painst ...
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 1

 TERMINÉ 

Transition into the Anthropocene: learning about the climate system from the 19th and early 20th century (TITAN)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The research proposed here will use a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of climate variability and change on the societally-relevant timescales of decades to centuries. Identifying the causes of observed changes in climate requires an understanding of the natural, internally generated variability of the clima ...
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 2

 TERMINÉ 

Non-coding RNA pathways and the mammalian male germline (NCRNA)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The integrity of the genome transmitted to the next generation intrinsically relies on germline cells. Processes ensuring germ cell development, genomic stability and reproductive lifespan are essential for the long-term success of a species. Spermatogonial stem cells (SSCs) support spermatogenesis throughout life, the identity of this mammalian adult stem cell population in vivo remains unknown. ...
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 2

 TERMINÉ 

Visual Culture for Image Understanding (VISCUL)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The goal of computer vision is to interpret complex visual scenes, by recognizing objects and understanding their spatial arrangement within the scene. Achieving this involves learningcategories from annotated training images. In the current paradigm, each category is learned starting from scratch without any previous knowledge. This is in contrast with how humans learn, who accumulate knowledge a ...
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 1

 TERMINÉ 

Cellular pathways determining growth and human brain size (HUMGENSIZE)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

The greatest differences between mammals are size. As well, the large evolutionary expansion of the cerebral cortex is a defining feature humans. Despite this, much remains to be learnt about the developmental and evolutionary factors controlling organ and organism size. This is in marked contrast to the exquisite detail in which developmental patterning has been defined in model organisms. The i ...
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 1

 TERMINÉ 

Machine learning for computational science: statistical and formal modelling of biological systems (MLCS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Computational modelling is changing the face of science. Many complex systems can be understood as embodied computational systems performing distributed computations on a massive scale. Biology is the discipline where these ideas find their most natural application: cells can be viewed as input/ output devices, with proteins and organelles behaving as finite state machines performing distributed c ...
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 1

 TERMINÉ 

Using novel methodologies to target and image cancer invasion and therapeutic resistance (CANCERINNOVATION)

Date du début: 1 août 2012, Date de fin: 31 juil. 2017,

We aim to develop and apply a suite of new technologies in a novel cancer discovery platform that will link high-definition cancer biology, via state-of-the-art disease imaging and pathway modelling, with development of novel interrogative and therapeutic interventions to test in models of cancer that closely resemble human disease. The work will lead to a new understanding of cancer invasion, how ...
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 1

 TERMINÉ 

Elucidation of the molecular and functional basis of disease phenotypes in the rat model (ELABORATE)

Date du début: 1 juin 2011, Date de fin: 31 mai 2017,

Recent genetic studies have identified hundreds of susceptibility genes for common human diseases but genetic effects are small and identifying underlying mechanisms remains challenging. Rodent models offer significant advantages for analysis of disease phenotypes. Advances in genome resources and gene targeting have increased the attractiveness of the rat model for genetic studies but progress ha ...
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 3

 TERMINÉ 

Persia and its Neighbours: the Archaeology of Late Antique Imperial Power in Iran (PERSIA)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

The Sasanian Empire (3rd-7th c. AD) stretched from Mesopotamia to the west of the Indian Subcontinent. A pilot study has shown that major frontier walls and geometrical fortifications, whose scale and sophistication surpasses those in contemporary Europe, date to the Sasanian era, as do grand urban foundations and canal systems. Yet, excavations and surveys of Sasanian monuments have been far and ...
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 7

 TERMINÉ 

Complex adaptation in photosynthetic microbes evolving in response to global change (EVOCHANGE)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2017,

Microbes evolve rapidly in changing environments, and global change may soon cause future microbial populations to differ genetically and phenotypically from contemporary populations. We have both pragmatic and intellectual interests in microbial evolution, especially when microbial communities perform important ecological services. For example, marine phytoplankton are responsible for half of glo ...
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 1

 TERMINÉ 

Investigating Networks of Zoonosis Innovation (INZI)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

INZI aims to analyse the complex interplay of actors, policies and projects that have shaped research into and control of Human African Trypanosomiasis (HAT) until the present day. Research has mainly been steered from outside of Africa, firstly by colonial authorities and latterly by an array of agencies, foundations and international organisations. Despite this, investment in research and contro ...
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 1

 TERMINÉ 

Listening to the Future: Next-generation Sound Synthesis through Simulation (NESS)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

This proposal is concerned with simulation-based approaches to sound synthesis, in the interest of generating very high quality synthetic sound of a natural acoustic character—partly to emulate real instruments, but also to explore classes of sounds which cannot be produced using conventional synthesis methods, or acoustic instruments. A further goal is to introduce such physical modelling synthes ...
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 1

 TERMINÉ 

Exploring the Inception of Galaxies and the Epoch of Reionization (EIGER)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

Studying the nature of the first generation of galaxies to form in the Universe is central to efforts to understand the earliest phases of galaxy evolution and the physical processes driving cosmic reionization. Building on my recent success investigating galaxy evolution at redshifts z>6, I propose to recruit and lead the research team necessary to fully exploit my involvement in two Hubble Spa ...
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 1