5 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
AP-1 (Fos/Jun) Functions in Physiology and Disease (AP-1-FUN)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2015,
Our research interests lie in breaking new ground in studying mechanism-based functions of AP-1 (Fos/Jun) in vivo with the aim of obtaining a more global perspective on AP-1 in human physiology and disease/cancer. The unresolved issues regarding the AP-1 subunit composition will be tackled biochemically and genetically in various cell types including bone, liver and skin, the primary organs affect ...
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TERMINÉ
Ras Genes in Health and Disease (RAS AHEAD)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
"Ras genes are some of the best-studied genes in biomedical research due to their central role in mitogenic signaling and their oncogenic activation in one third of all human tumors. More recently, Ras genes have also been implicated in developmental disorders including Costello and Noonan syndromes. In spite of this wealth of information, we still do not know the role of Ras proteins in adult hom ...
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TERMINÉ
COMMOM MECHANISMS UNDERLYING CANCER AND AGEING (CANCER&AGEING)
Date du début: 1 avr. 2009, Date de fin: 31 mars 2015,
"In recent years, we have made significant contributions to the understanding of the tumour suppressors p53, p16INK4a, and ARF, particularly in relation with cellular senescence and aging. The current project is motivated by two hypothesis: 1) that the INK4/ARF locus is a sensor of epigenetic damage and this is at the basis of its activation by oncogenes and aging; and, 2) that the accumulation o ...
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TERMINÉ
Molecular characterization and targeted elimination of metastatic pancreatic cancer stem cells (PA-CSC)
Date du début: 1 juil. 2009, Date de fin: 31 déc. 2014,
Pancreatic adenocarcinoma is the deadliest solid cancer and currently the fourth most frequent cause for cancer related deaths. Over the past decades, there has hardly been any substantial therapeutic progress regarding clinical endpoints. New hope has now been generated by the re-emerging cancer stem cell (CSC) concept. We have identified and characterized pancreatic CSC in the context of tumour ...
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TERMINÉ
FROM TELOMERE CHROMATIN TO STEM CELL BIOLOGY (TEL STEM CELL)
Date du début: 1 mai 2009, Date de fin: 31 déc. 2014,
Telomeres are ribonucleoprotein complexes at the ends of chromosomes that are essential for chromosome protection and genomic stability. Telomeres consist of tandem TTAGGG repeats bound to a 6-protein complex known as shelterin. More recently, telomeres have been also shown to contain long non-coding telomeric RNAs (TelRNAs or TERRAs), which are associated to the telomeric chromatin and have been ...
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