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 EN COURS 
Due to lack of targeted interventions, compliance issues, insufficient effect sizes and a high non-responder rate to currently available interventions, there is an urgent need to develop innovative and new interventions for chronic paediatric neuropsychiatric disorders, such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Transcranial direct current stimulati ...
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 12

 EN COURS 
The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi ...
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 43

 EN COURS 

EURopean Endeavour for Chimeric Antigen Receptor Therapies (EURE-CART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Cancer is rapidly becoming the most frequent cause of death in EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are major causes of chronic diseases. Adoptive immunotherapy with T cells genetically modified with a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer without causing ...
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 11

 EN COURS 
Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 EN COURS 
Mental, cognitive, vision and hearing health problems in elderly people are amongst the top 10 public health challenges in Europe. They frequently occur co-concurrently and have an additive negative effect on quality of life and mental well-being. To address this negative impact, and promote mental well-being, particularly from a gender and minority community perspective, SENSE-Cog's aim is to: (1 ...
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 18

 TERMINÉ 
Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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 20

 TERMINÉ 

Secondary prEvention of CardiovascUlaR disease in the Elderly trial (SECURE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adhe ...
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 13

 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 
Liquid hydrocarbon fuels are ideal energy carriers for the transportation sector due to their exceptionally high energy density and most convenient handling, without requiring changes in the existing global infrastructure. Currently, virtually all renewable hydrocarbon fuels originate from biomass. Their feasibility to meet the global fuel demand and their environmental impact are controversial. I ...
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 8

 TERMINÉ 
Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous p ...
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 11

 TERMINÉ 
The overall aim of the SOTERIA project is to improve the understanding of the ageing phenomena occurring in reactor pressure vessel (RPV) steels and in the internal steels (internals) in order to provide crucial information to regulators and operators to ensure safe long-term operation (LTO) of existing European nuclear power plants (NPPs). SOTERIA has set up a collaborative research consortium wh ...
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 25

 TERMINÉ 
The enduring humanitarian crisis in the Middle East, the unrelenting high levels of violence in Afghanistan and new outbursts of violence in South-Sudan have made 2014 another record-breaking year for acts of violence against humanitarian aid workers. In 2000 41 significant attacks on aid workers were recorded across the globe. By 2014, that number had risen to 190. In this 15-year period, over 3, ...
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 12

 TERMINÉ 
This three-year project is to release, validate and verify a unique computer environment (i.e. the EPICEA platform) assimilating a complete understanding of electromagnetic (EM) issues on Composite Electric Aircraft (CEA – i.e. aircraft with composite and electric technologies combined and operating at higher altitude/latitude). EM on CEA includes EM coupling, interconnects, and Cosmic Radiations ...
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 5

 TERMINÉ 
The share of renewable energy is growing rapidly driven by the objective to reduce greenhouse gas emissions. The amount of electric power which can be supplied to the grid depends on the time of the day and weather conditions. A conventional fleet of thermal power plants is required to compensate for these fluctuations before large scale energy storage technologies will be mature and economically ...
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 23

 TERMINÉ 

effective Container inspection at BORDer control points (C-BORD)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2018,

Efficient NII (non-intrusive inspection) of containerised freight is critical to trade and society. Freight containers are potential means for smuggling (e.g. tobacco), illegal immigration, trafficking of drugs, mis-declared goods and dangerous illicit substances, including explosives, nuclear material, chemical and biological warfare agents and radioactively contaminated goods. One inspection NII ...
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 19

 TERMINÉ 

Ecology from Farm to Fork Of microbial drug Resistance and Transmission (EFFORT)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

EFFORT studies the complex epidemiology and ecology of antimicrobial resistance and the interactions between bacterial communities, commensals and pathogens in animals, the food chain and the environment.This will be conducted by a combination of epidemiological and ecological studies using newly developed molecular and bio-informatics technologies. EFFORT will include an exposure assessment of hu ...
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 21

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 
The main objective of the HemAcure project is to develop and refine the tools and technologies for a novel ex vivo prepared cell based therapy to treat the bleeding disease haemophilia A (caused by genetic deficiency in clotting factor VIII (FVIII)) that should ultimately lead to improved quality of life of the patients. The concept is a further development of our approach, established during the ...
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 7

 TERMINÉ 

Labeling of Enalapril from Neonates up to Adolescents (LENA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Children are often treated as small adults—not as the special patients they are. Regulations exist to encourage the development of drugs and formulation for children. However, off-patent drugs are often administered to children without appropriate formulations or systematic investigations. Therefore, the paediatric use marketing authorisation (PUMA) has been designed.The EMA Paediatric Working Par ...
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 14

 TERMINÉ 

Satellite Swarm Sensor NETwork (S3NET)

Date du début: 1 mai 2016, Date de fin: 31 oct. 2018,

The implementation of the S3NET concept as proposed by this consortium, will significantly advance the knowledge and decision-making capabilities for the space community in general and mission planners in particular. Through the enhancement and efficient use of on-board resources (computing power, communications and fuel) the improvements in performance of Earth observations (EO) using fractionate ...
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 8

 TERMINÉ 

DRiving InnoVation in crisis management for European Resilience (DRIVER)

Date du début: 1 mai 2014, Date de fin: 31 oct. 2018,

DRIVER starts from the experience that neither successful R&D nor strong end-user demand always lead to innovation in the Crisis Management (CM) domain. This is a problem since as societies become more complex, increasing scope and unpredictability of potential crises and faster dynamics of major incidents put increasingly stringent demands on CM. European CM capabilities already constitute a matu ...
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 38

 TERMINÉ 

Personalised Prognostic Tools for Early Psychosis Management (PRONIA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Affective and non-affective psychoses have a major negative impact on human society. They account for 6.3% of the global burden of disease and cost €207 billion per year in Europe alone, making them the most expensive brain-related disorders and even more expensive than cardiovascular diseases. This socioeconomic burden is largely caused by two core disease features: onset in adolescence and early ...
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 13

 TERMINÉ 
With the ULTIMATE project five experienced research groups and four major European engine manufacturers will develop innovative propulsion systems to fulfill the SRIA 2050 key challenges. One of the most challenging targets is the 75% reduction in energy consumption and CO2-emissions. Technologies currently at TRL 3-5, cannot achieve this aim. It is estimated that around a 30% reduction must come ...
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 11

 TERMINÉ 

MicroRNAs in the Pathogenesis, Treatment and Prevention of Epilepsy (EPIMIRNA)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Epilepsy is a major burden for patients and health systems worldwide. It is a common chronic neurological disorder affecting people of all ages, and the shortfall in existing treatments means that 30% of patients continue to suffer uncontrolled seizures. MicroRNAs (miRNA) are a recently-discovered, network-level layer of gene expression regulation that controls protein levels of entire signaling p ...
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 19

 TERMINÉ 
Europe is confronted by a demographic challenge as a decreasing work force has to support an increasing elderly population. The economic risk implied by this burden could be addressed by efforts to achieve an increase in Healthy Life Years. One key element would be to ensure unrestricted mobility for especially the elderly, allowing them to stay at work for longer. Irreversible joint deterioration ...
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 11

 TERMINÉ 

Novel Integration of Powerplant System Equipment (NIPSE)

Date du début: 1 juin 2015, Date de fin: 31 mai 2018,

The main objectives of NIPSE are to provide technologies to- reduce Integrated PowerPlant System development time of future aeroengines by 10%- enable the 2 to 3% environmental related gains in fuel burn and reduction in emissions looked at by these new aeroengine architectures (especially Ultra High Bypass Ratio and Open Rotor) through improved aeroengine equipment solutions. The objectives will ...
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 10

 TERMINÉ 

Innovative Welding Processes for New Rail Infrastructures (WRIST)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

WRIST will develop and demonstrate flexible and cost effective joining processes for rail products, and in particular for advanced bainitic rail steels, which have been developed to answer the increasing demands of increasing speed and growth of railway’s load. This will be delivered by the combined development of the joining processes itself, welding experiments, computational modelling, material ...
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 10

 TERMINÉ 

Training Augmented Reality Generalised Environment Toolkit (TARGET)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

TARGET will deliver a pan-European serious gaming platform featuring new tools, techniques and content for training and assessing skills and competencies of SCA (Security Critical Agents - counterterrorism units, border guards, first responders (police, firefighters, ambulance services civil security agencies, critical infrastructure operators).Mixed-reality experiences will immerse trainees at ta ...
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 19

 TERMINÉ 
Conduct Disorder (CD) and Oppositional Defiant Disorder with symptoms of Conduct Disorder (which is included among the abbreviation “CD” throughout the proposal) has a highly negative impact for the affected individual as well as for families and society. Although the number of females exhibiting serious aggressive behaviours is growing, the majority of studies on aetiology and treatment of CD hav ...
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 19

 TERMINÉ 
Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects.Current cartilage implants cannot establish th ...
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 18

 TERMINÉ 

European Lead Factory (EUC²LID)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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 34

 TERMINÉ 

Systems medicine of chronic inflammatory bowel disease (SYSMEDIBD)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillat ...
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 13

 TERMINÉ 
The European population of older people with multiple chronic diseases (multimorbidity) is increasing steadily in tandem with the rising population of people aged ≥ 65 years. Older multimorbid people are at high risk of polypharmacy (PP), inappropriate prescribing (IP), adverse drug reactions (ADRs) and adverse drug events (ADEs). PP, IP, ADRs and ADEs in turn cause excessive drug costs and excess ...
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 13

 TERMINÉ 
Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategie ...
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 17

 TERMINÉ 
In 2011, the White Paper on European Transport reasserted how fundamental transport was for society, for the mobility of European citizens and for the growth and vitality of the European economy.CAPACITY4RAIL will deliver research that is innovative, prepares rail for the future and takes into account results from previous research projects and programmes. The project builds on previous useable re ...
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 48

 TERMINÉ 

Engine Module Validators (ENOVAL)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The ENOVAL project will provide the next step of engine technologies to achieve and surpass the ACARE 2020 goals on the way towards Flightpath 2050. ENOVAL completes the European 7th Framework Programme (FP7) roadmap of Level 2 aero engine projects. ENOVAL will focus on the low pressure system of ultra-high by-pass ratio propulsion systems (12 < BPR < 20) in conjunction with ultra high overall pre ...
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 37

 TERMINÉ 
In search for a more competitive, multiple types of aircrafts, IMA based, avionics platform solution, the European aerospace industry has recently initiated the IMA2G paradigm thanks to the EC funded SCARLETT project.This latter successfully validated a first underlying set of IMA2G concepts (Separate Core Processing resources from I/O resources, introduce resource segments typology of electronics ...
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 39

 TERMINÉ 
The mission of the NextFactory project is to develop and validate a new type of all-in-one manufacturing technology combining, for the first time, in a single piece of equipment, 3D freeform printing and ultra-precision 3D assembly. This highly flexible and scalable facility will empower microsystem manufacturers - and in particular SMEs - to effectively produce highly miniaturised Smart Products- ...
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 11

 TERMINÉ 

DIAmond Devices Enabled Metrology and Sensing (DIADEMS)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible.The objectives of DIADEMS are ...
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 17

 TERMINÉ 
Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. The clinician is faced with the decision to either 1) intervene only on the culprit lesion acutely responsible for the i ...
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 23