7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The Role of Langerhans Cells in T-Cell Priming During Intradermal Naked DNA Immunization (SkinImmunity)
Date du début: 1 sept. 2008, Date de fin: 31 août 2012,
Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have a dominant role in initiating T-cell responses. The skin is populated by at least two subsets of DCs: Langerhans cells (LCs), which form a contiguous network throughout the epidermis, and dermal DC. According to the conventional paradigm, LCs perform a sentinel function by detecting skin pathogens and integrating this ...
Voir le projet
1
Participant partenaire
TERMINÉ
Manipulating different arms of the immune system to orchestrate tumor-specific immunity and enhance tumor clearance (Immunotherapy)
Date du début: 1 sept. 2009, Date de fin: 31 août 2013,
...romoter to ensure GM-CSF production exclusively in tumor cells (an oncolytic virus replicates only in tumor cells). GM-CSF is a potent cytokine that enhances the function of antigen presenting cells (APCs) by the maturation, activation, and recruitment of DCs, macrophages and monocytes.All biologic responses crucial for DC functioning are influenced by signaling through the Toll-like receptors (TL ...
Voir le projet
1
Participant partenaire
TERMINÉ
Spatio-temporal regulation of antigen presentation and cell migration (STRAPACEMI)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2015,
...ulations, which circulate between lymphoid organs and peripheral tissues as a result of their high migratory capacity. We have shown that Antigen (Ag) processing and migration of Ag Presenting Cells (APCs) are co-regulated by a protein complex that contains the MHC class II-associated Invariant Chain (Ii) and the actin-based motor protein Myosin II. While the association between Ii and Myosin II p ...
Voir le projet
1
Participant partenaire
TERMINÉ
Probing the function of dermal macrophages by lectin targeting for potential application to autoimmune diseases (DERMACRO)
Date du début: 1 juin 2013, Date de fin: 31 mai 2017,
...ublic health systems.An optimal treatment would consist in a specific control of anti-self immune responses, without compromising the ability to fight infections and cancer. Antigen-presenting cells (APCs) that control the fate of self-specific T cells represent an attractive target, because abnormal differentiation of T cells is a critical turning point in most autoimmune diseases. Moreover, T ce ...
Voir le projet
1
Participant partenaire
TERMINÉ
Novel properties of antigen receptors and instruments to modulate lymphoid function in physiological and pathological conditions (NOVARIPP)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
...sential role in a variety of TCR signaling functions including tonic signaling and TCR downregulation. Furthermore, we have found that TC21 is required for the acquisition of pMHC by T cells from the APCs and re-express it on their own plasma membrane, becoming themselves APCs for other T cells. In this proposal we wish to explore several of the avenues open by our most recent findings, including ...
Voir le projet
1
Participant partenaire
TERMINÉ
Unravelling cross-presentation pathways using a chemical biology approach (Crosstag)
Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,
...ntigen presenting cells. The most intriguing of these is the mannose receptor (MR) as the method by which it does this is unknown. This glycoprotein-binding receptor appears to have two functions on APCs: general uptake-enhancement and, in certain isolated cases, cross-presentation-enhancment. What ligand parameters are important in causing cross-presentation enhancement is not known. Current too ...
Voir le projet
1
Participant partenaire
TERMINÉ
Mobilidade na EU
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
ETAP has developed activity in Vocational Education and Training aimed at young people and adults for 25 years. Headquartered in the city of Caminha in the Alto Minho region, is the oldest vocational school in the Northern Region and was the second to be established at national level. It is one of the schools with more experience in placements and exchanges at transnational level. The teaching and ...
Voir le projet