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33 projets européens trouvés

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 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

 TERMINÉ 

Clinical Translation of Patient-Specific Planning and Conduction of FUS Treatment in Moving Organs (TRANS-FUSIMO)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

MR-guided Focused Ultrasound Surgery (MRgFUS) combines high intensity focused ultrasound for thermal ablation of diseased tissue with MR imaging to visualise the tumour and surrounding anatomy and to provide MR thermal feedback.However, MRgFUS treatment of the liver and other abdominal organs present tremendous technological challenges, including motion due to breathing and shielding of the target ...
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 11

 TERMINÉ 

Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

Use of BioEngineered Plant-Integrated Cover (BioEPIC) to Enhance Slope Performance (BioEPIC Slope)

Date du début: 6 oct. 2014, Date de fin: 5 oct. 2018,

Climate change threatens the stability of infrastructure slopes, which form a large proportion of the European transport network. Slope failures due to increasing intense rainfall have already resulted in significant socio-economic loss across the Europe. Slope revegetation is identified as a more environmentally friendly and aesthetically pleasing stabilisation technique, when compared to other h ...
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 1

 TERMINÉ 

Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (DrugE3CRLs)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

This proposal is centred on the development and application of chemical tools to probe molecular recognition of multiprotein complexes. Although much effort has been devoted to targeting protein-protein interactions using small molecules, these have focused to date on individual gene products or truncated domains, which however do not reflect the physiological organization and activity of many fun ...
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 1

 TERMINÉ 

Parasite glycobiology and anti-parasitic strategies (GLYCOPAR)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

"Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the pa ...
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 13

 TERMINÉ 

Kinetics for Drug Discovery (K4DD) (K4DD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

There is mounting evidence that the often ignored kinetic aspects of the interaction between a drug and its target are highly relevant for clinical success. This ignorance may be one of the reasons for the high attrition rates in drug discovery, as it has been analyzed that many recently marketed drugs had indeed improved kinetic profiles. This hindsight knowledge needs to be converted into data-d ...
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 21

 TERMINÉ 

PHOtonic tools for Quantitative imaging in tissUeS (PHOQUS)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"The PHOtonic tools for Quantitative imaging in Cells and tissUeS IDP (PHOQUS) will seed a revolution in the development and application of novel imaging modalities and multimodalities to enable the quantitative investigation of biological processes at multiple size regimes from the molecular and cellular to the tissue and organ level scale , by training graduate Physicists and Biologists for the ...
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 1

 TERMINÉ 

Development of hemodynamic solutions in Renal Dialysis Venous Access Failure (ReDVA)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

The ReDVA project proposes to perform a joint industry-academia research programme to overcome the scientific and technical barriers to the understanding, development and adoption of technologies to combat the significant clinical problem of the failure of renal dialysis venous access. The partnership will capitalise on the exchange of complementary inter-disciplinary knowledge and expertise betwe ...
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 5

 TERMINÉ 

Identifying the targets and mechanism of action of the SUMO targeted ubiquitin ligase RNF4 in response to distinct DNA lesions (RNF4 in the DDR)

Date du début: 1 juil. 2014, Date de fin: 19 août 2017,

The Ubiquitin (UB) and SUMO modification pathways have recently been shown to be important regulators of genome stability. However, despite their significance, we do not have a detailed understanding of which repair proteins they modify, nor how they promote DNA repair. This proposal aims to address this by studying the human protein RNF4, which sits at the interface between the UB and SUMO pathwa ...
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 1

 TERMINÉ 

Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified (CFMATTERS)

Date du début: 1 oct. 2013, Date de fin: 30 juin 2017,

Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caus ...
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 15

 TERMINÉ 

"Retinal Vascular Modeling, Measurement and Diagnosis" (REVAMMAD)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"The REtinal VAscular Modeling, Measurement And Diagnosis (REVAMMAD) project will train a new generation of scientists able to effectively translate the latest vascular modeling theory and computerized image analysis techniques into effective interventions for some of the most important chronic medic conditions afflicting the EU, including hypertension and diabetes. It will particularly ensure tha ...
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 10

 TERMINÉ 

Focused Ultrasound Therapy Using Robotic Approaches (FUTURA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

Focused Ultrasound Therapy Using Robotic Approaches (FUTURA) aims at creating an innovative multi-robotic platform for non-invasive interventions. The project addresses all specific issues necessary for a concrete and effective transfer of robotic technologies into operating rooms. The robotic platform is expected to operate in an unstructured and extremely critical environment; perception capabil ...
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 6

 TERMINÉ 

Nanostructured Efficient White LEDs based on short-period superlattices and quantum dots (NEWLED)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

NEWLED will develop high efficiency and high brightness monolithic and hybrid all-semiconductor WHITE light-emitting GaN-based diodes. Power losses due to phosphor conversion and the problem of different ageing rates of the GaN LED pump will be eliminated by the development of phosphor free structures with increased brightness (power emitted per surface per angle). NEWLED will enhance the efficien ...
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 15

 TERMINÉ 

Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration (OPTIMISTIC)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

OPTIMISTIC is a proposal for a European collaborative project of doctors, scientists, relevant stakeholders (TREAT-NMD, patient organizations) and SMEs with the aim to improve clinical practice for patients suffering from a rare, inherited, and neglected disease, myotonic dystrophy type 1 (DM1). It is one of the most variable human diseases with complex, multi-systemic and progressively worsening ...
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 9

 TERMINÉ 

Concept Invention Theory (COINVENT)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

The capacity of combinational creativity---i.e., when novel ideas are produced through unfamiliar combinations of familiar ideas---is difficult to recreate computationally. In particular, it is a hard task for autonomous computational systems to tackle the combinatorial explosion of potential combinations, and to be capable of recognizing the value of newly created ideas (concepts, theories, solut ...
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 9

 TERMINÉ 

Agencies in EU Foreign Policy: RELEX-Agencification (Relex-Agencification)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

This project examines a widespread, yet under-researched, trend in European politics, namely the transformation of EU foreign policy through processes of ‘agencification’. In what can be seen as a revolutionary move, an ever increasing number of European foreign policy tasks are being delegated to European agencies – that is, specialised and ‘depoliticised’ administrative structures – or, in other ...
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 1

 TERMINÉ 

Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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 10

 TERMINÉ 

Magnetically Enhanced Controlled Axonal Regeneration (MECAR)

Date du début: 7 juil. 2014, Date de fin: 6 juil. 2016,

Although the exact mechanisms involved in the growth of axons is still incompletely understood, it is clear that force is a crucial factor for both axonal guidance and lengthening. Indeed, there is a growing body of evidence indicating the importance of physical stimuli for neuronal growth and development. Results of published experimental studies indicate that forces, when carefully controlled, a ...
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 1

 TERMINÉ 

Extracellular Matrix Remodeling and Muscle Insulin Resistance: Role of Hyaluronan-CD44 Interaction (EMRAMIR)

Date du début: 1 juin 2014, Date de fin: 31 mai 2016,

The rapid increase in the worldwide prevalence of type 2 diabetes (T2D) and metabolic diseases has led to a high demand for identifying new and more effective treatments. Skeletal muscle insulin resistance, a hallmark of T2D and metabolic syndrome, has been primarily studied for the identification of novel therapeutic targets and the development of cost-effective drugs. Our previous results have e ...
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 1

 TERMINÉ 

Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children, affecting approximately 5% children in Europe. Methylphenidate (MPH) is the most-commonly prescribed medication for ADHD children; it is also increasingly used in ADHD adults. In 2007, the European Commission requested a referral to the Committee for Medicinal Products for Human Use ...
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 17

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Identification of molecular transporters that facilitate siRNA skin delivery (SITRANSPORTER)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

The ability to target gene expression with nucleic acid-based therapeutics including small interfering RNAs (siRNAs) has opened up novel treatment opportunities for genetic skin disorders. Although siRNAs have exquisite selectivity and potency, translation to the clinic has been hampered due to the lack of efficient delivery systems that allow penetration through the outer barrier of the skin, the ...
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 1

 TERMINÉ 

Biological and Mathematical Basis of Interaction Computing (BIOMICS)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2016,

Interaction Computing (IC) takes inspiration from cellular processes rather than from evolution. BIOMICS aims to leverage existing cell metabolic and regulatory mechanisms as the ontogenetic basis of a model for IC. However, because the knowledge to properly mimic, exploit and adapt these systems to computer science is lacking, BIOMICS will also advance the state of the art in the mathematics of b ...
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 4

 TERMINÉ 

Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy Through Integrated Tissue Micro-Structure Modeling (VPH-PRISM)

Date du début: 1 mars 2013, Date de fin: 29 févr. 2016,

Description Personalised predictive modelling of breast cancer allows treatment stratification, preventing unnecessary and unsuccessful treatments. VPH-PRISM (Virtual Physiological Human: Personalized Predictive Breast Cancer Therapy through Integrated Tissue Micro-Structure Modeling) addresses these key topics with integrated multidisciplin ...
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 9

 TERMINÉ 

Geotechnical design solutions for the offshore renewable wave energy industry (GeoWAVE)

Date du début: 3 sept. 2012, Date de fin: 2 août 2015,

Sustainable offshore wave energy has the potential to make a real contribution towards the binding EU commitment to source 20% of its electricity requirements from renewable sources by 2020. The vast wave energy resource along Europe’s western seaboard is unparalleled anywhere in the world. Consequently the EU has an opportunity to become international industry leaders in what is becoming a rapidl ...
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 10

 TERMINÉ 

bioMARkers and molecular tumor classification for non-genotoxic CARcinogenesis (MARCAR)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

MARCAR aims to establish reliable early markers and molecular classification of tumors in non genotoxic carcinogenesis, applying a mechanism-based approach. Benefits are improved drug safety, more efficient drug development, and progress with 3 R issues. MARCAR focuses on rodent liver, the major target organ of non-genotoxic carcinogens (NGC). However, this approach will facilitate predictions for ...
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 12

 TERMINÉ 

Design of orthogonal molecular probes targeting engineered von-Hippel Lindau (VHL) E3 ubiquitin ligase for the control of intracellular protein levels (orthoPROTACS)

Date du début: 8 avr. 2013, Date de fin: 7 avr. 2015,

The development of potent, selective and cell-permeable small molecule chemical probes as tools to interrogate and modulate cellular functions of the human proteome is a rapidly growing field. The direct manipulation of protein intracellular level and activity using small molecules has enormous potential to elucidate and validate new drug targets and therapeutics tools. In the last decade, resear ...
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 1

 TERMINÉ 

PRACTICAL LIGHT TYPES FOR RESOURCE CONSUMPTION (PLATFORM)

Date du début: 25 juil. 2011, Date de fin: 24 juil. 2014,

"Eliminating errors early in the software-design life cycle is crucial to reduce the tremendous societal cost represented by defective software. Modern programming languages offer a variety of techniques for ensuring, at design time, the correctness of software systems with respect to the desired behaviors. However, these techniques do not consider usually the software aspects related to programs ...
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 2

 TERMINÉ 

SPACEWIRE RT (SpWRT)

Date du début: 1 juin 2011, Date de fin: 31 mai 2013,

The trend towards “Operationally Responsive Space”, where spacecraft can be rapidly assembled, configured and deployed, to meet specific mission needs, e.g. disaster support, requires flexible on board communication networks with plug-and-play capability. The growing autonomy of scientific missions to remote planets requires networks that are robust and durable, able to recover from transitory err ...
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 5

 TERMINÉ 

"The identification, characterisation and exploitation of novel Gram-negative drug targets." (AEROPATH)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

"An ambitious long-term programme of multidisciplinary research with two closely linked objectives is proposed to support antimicrobial drug development. Firstly, to advance understanding, at the molecular level, of fundamental and important aspects of the biology of Gram-negative bacteria using the important pathogen model Pseudomonas aeruginosa. Secondly, and most important, to exploit our disco ...
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 5

 TERMINÉ 

Nucleobase derivatives as drugs against trypanosomal diseases (trypobase)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The protozoan diseases, leishmaniasis, African trypanosomiasis and Chagas’ disease are responsible for substantial global morbidity, mortality, and economic adversity, and in most countries, existing strategies for control and treatment are either failing or under serious threat. New tools for combating pathogenic protozoa and the development and exploitation of new drug targets are required. This ...
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 7