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Marine phycotoxins such as spirolides produced by toxic dinoflagellates concentrate in shellfish tissues, and by vectorial transport reach marine animals and humans. In 2005, spirolides have been detected in oysters in the Arcachon bay (France), and sanitary authorities have banned their commercialization, causing heavy losses to shellfish farms around. To date, no toxicological study has been con ...

"Multicomponent reactions (MCR) have recently attracted a great deal of attention as they are considered as a kind of “holy grail” for organic chemists. Although new examples are constantly flourishing in the literature, there are a limited number of processes that allow multiple components to react together in a single operation. We propose to develop new processes involving two consecutive multi ...