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 TERMINÉ 

Comparing the effectiveness of palliative care for elderly people in long term care facilities in Europe (PACE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"Aging populations, rising costs and sustainable delivery of high-quality care are increasingly common concerns in all EU countries. PACE aims to perform comparative effectiveness research concerning palliative care in long term care facilities (LTCFs) in Europe. While a growing number of older people will require palliative care in institutionalized settings, palliative care has only recently beg ...
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 13

 TERMINÉ 

Membrane partitioning of homologous proteins (MEMPART)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

My goal is to elucidate how structurally closely-related proteins are selectively partitioned in distinct membrane domains that allow localization, clustering and segregation of specific cellular activities. Although many of the mechanisms that govern membrane organization are increasingly well understood, such as lipid ‘rafts’ or protein-anchoring to the cortical cytoskeleton, these mechanisms ar ...
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 1

 TERMINÉ 

Social innovation to improve physical activity and sedentary behaviour through elite European football clubs: European Fans in Training (EuroFIT)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Concept and aim: 20 million fans attend top division football games each week and many more watch on TV. Our social innovation is to attract people to lifestyle change through the personal connection and loyalty to the club they support. Our aim is to use this social innovation to change physical activity and sedentary behaviour, specially targeting low-SES groups, and men as well as women. EuroFI ...
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 13

 TERMINÉ 

Clinical ultrasound platform for the quantitative and longitudinal imaging of theranostics and cellular therapy (CoNQUeST)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

The success of modern medical treatments such as cellular therapy and targeted treatments requires appropriate tools for in vivo monitoring. Imaging modalities, such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) are key candidates due to their noninvasive nature. However, these imaging techniques are extremely expensi ...
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 1

 TERMINÉ 

Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease (CosmoPHOS-nano)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic thera ...
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 20

 TERMINÉ 

Preserving old antibiotics for the future : assessment of clinical efficacy by a pharmacokinetic/pharmacodynamic approach to optimize effectiveness and reduce resistance for off-patent antibiotics (AIDA)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2017,

The AIDA project aims to answer the question of clinical effectiveness and optimal dosing of 5 off-patent antibiotics for infections caused by multiple drug resistant (MDR) bacteria in three randomized controlled clinical trials. In an era of increasing emergence of drug resistance (EDR) and lack of new antibiotics, old off- patent antibiotics are increasingly being prescribed to patients. However ...
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 19

 TERMINÉ 

Mimicking pathogens; an integrated nano-medicine approach to developing intelligent cancer vaccines (PATHFINDER)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

"Tumour cells survive and grow because they are not effectively recognized by the immune system as ¿foreign¿ and are therefore not attacked and destroyed like most pathogens. We have already demonstrated the clinical value of dendritic cell (DC) vaccines that activate the immune system to fight cancer. Treating more than 300 patients with metastatic melanoma, we achieved extended survival in 40% o ...
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 1

 TERMINÉ 

European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
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 29

 TERMINÉ 

Trojan-Lipid-Sensor

Date du début: 16 sept. 2014, Date de fin: 15 sept. 2017,

Modulation of leukocyte adhesiveness is critical to leukocyte function during the immune response. In order to extravasate from the blood stream, leukocyte rolling must be followed by integrin-mediated rapid arrest. Intergins play a crucial role on chemokine-induced arrest of leukocytes on blood vessels. Signaling events mediating adhesion are extensively studied. Increasing evidence underlays the ...
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 1

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

The genetic basis of meningococcal and other life threatening bacterial infections of childhood (EUCLIDS)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2017,

Bacterial infection is the major cause of disability and death in children worldwide. We will use meningococcal disease (MD) as a model to understand genetic factors underlying susceptibility and severity of childhood bacterial infection which will then be applied to other childhood infections. We have established cohorts of patients with MD in Central and Southern Europe (CE,SE), UK and Africa as ...
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 16

 TERMINÉ 

Co-morbidity in relation to Aids (COBRA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, de ...
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 12

 TERMINÉ 

Clinical Intervention Modelling, Planning and Proof for Ablation Cancer Treatment (ClinicIMPPACT)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2017,

The ClinicIMPPACT proposal builds upon the successful completion of the IMPPACT project (Grant No. 223877, completed in February 2012) that resulted in the creation of a physiological radio-frequency ablation (RFA) model for liver cancer treatment. This preliminary RFA model has been tested in porcine animal studies with extensive histological workup and in a clinical study using patient data for ...
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 8

 TERMINÉ 

Detection and interpretation of de novo mutations and structural genomic variations in mental retardation (DENOVO)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

"Mental retardation, like most common neurodevelopmental and psychiatric diseases, shows a strong genetic component, but these underlying genetic causes remain largely unknown. For a long time it was hypothesized that these kind of common diseases are mainly caused by common inherited genetic variants with reduced penetrance. In contrast to this common variant-common disease hypothesis, I here hyp ...
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 1

 TERMINÉ 

Integrative strategy for the development of urinary bladder analogs (REBTX)

Date du début: 1 mars 2014, Date de fin: 5 déc. 2016,

The current treatment of bladder defects is often associated with high site morbidity and patient discomfort. The therapeutic standard methods, involve the use of materials with low biological performance and lack in replicating the bladder’s anatomical structure. Regenerative Bladder Therapy (ReBTx) aims in addressing the reconstruction of the bladder by using an innovative bottom-up approach, to ...
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 1

 TERMINÉ 

Beyond the Genome; training the next generation of ophthalmic researchers (EyeTN)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Eye research has often blazed a trail for other disciplines to follow, giving a lead in neuroscience, genetics, the development of gene- and stem-cell therapies and other important areas of medical research. In recent years, geneticists have made many remarkable discoveries of relevance both to normal human vision and the development of inherited retinal pathology. However the genes and mutations ...
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 7

 TERMINÉ 

A novel generation of skin substitutes to clinically treat a broad spectrum of severe skin defects (EUROSKINGRAFT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

Large full-thickness skin defects resulting from burns, soft tissue trauma, congenital giant nevi, tumour resection, and disease leading to skin necrosis, represent a significant and common clinical problem worldwide. This problem is far from being solved. The main challenge encountered is that most autologous skin grafting techniques are based on transplanting split-thickness skin (the today’s go ...
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 11

 TERMINÉ 

Interdisciplinary training network for Tourette Syndrome; structuring European Training capacities for neurodevelopmental disorders (TS-EUROTRAIN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

There is a striking lack in structured and standardized training infrastructure for neurodevelopmental disorders across Europe. Such training will be fundamental to promoting standards of care across Europe and will ultimately lead to strategies for the promotion of childhood mental health in Europe. The focus of this Initial Training Network (ITN) is Gilles de la Tourette Syndrome (TS), an inheri ...
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 12

 TERMINÉ 

European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity (EuroTARGET)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical ...
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 15

 TERMINÉ 

Effective Perinatal Intensive Care in Europe: translating knowledge into evidence based practice (EPICE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

"Context: Very preterm infants face high risks of mortality and long-term neuro-developmental impairment. Rates of mortality and morbidity vary by a factor greater than two between European regions. This project’s overriding aim is to improve these infants’ survival and long-term health and development by ensuring that available medical knowledge is translated into effective perinatal care.Objecti ...
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 14

 TERMINÉ 

The potential of human kidney stem/progenitor cells for use in drug discovery and regenerative therapy programmes (NEPHROTOOLS)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

Renal disease is a global public health problem, with the incidence of end stage renal disease (ESRD) rising annually. Current treatment options for ESRD are dialysis or renal transplantation, which have significant drawbacks in terms of increased morbidity and mortality, besides placing an increasing economic burden on society. The development of interventions aimed at preventing ESRD, including ...
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 11

 TERMINÉ 

Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients ...
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 11

 TERMINÉ 

A genomics toolbox to enhance business for SMEs in the market of starter cultures and probiotics (GENOBOX)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

Fermented food (e.g. cheese, yoghurt, bread, wine) constitute a large part of our diet. They are converted from a substrate (milk, fruits, cereals) by the action of micro-organisms (yeast or lactic acid bacteria). When such starter cultures also exert a health benefit (eg. prevention of diarrhea) they are known as probiotic strains. Throughout the EU starters and probiotic strains are mainly suppl ...
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 6

 TERMINÉ 

European multicenter network to evaluate pharmacokinetics, safety and efficacy of Meropenem in neonatal sepsis and meningitis (NEOMERO)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Previous studies have demonstrated the high frequency of bacterial sepsis in neonates and infants admitted to neonatal intensive care unit (NICU), often associated with serious complications or death. Many pathogens capable of causing nosocomial bacterial sepsis in neonates and young infants have developed resistance to the antibiotics considered of choice for treatment. Meropenem is an antibiotic ...
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 12

 TERMINÉ 

Genetic and Epigenetic Networks in Cognitive Dysfunction (GENCODYS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

Mutations in about 400 different genes have been associated with Cognitive Disorders (CD), such as mental retardation, autism, neurodegenerative disorders, and psychiatric disorders. Whereas CD impose a major medical and socio-economical problem, there are no systematic studies that aim to provide insight into common mechanisms in CD. We propose a systems biology approach to gain insight into comm ...
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 15

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

 TERMINÉ 

Mental Retardation: Harnessing the Glutamate Hypofunction Hypothesis (MERE-GLU)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

Mental retardation (MR) imposes a major medical and social-economical problem in our society. It is defined as a global reduction in cognitive and intellectual abilities, which manifests before the age of 18, and is estimated to affect 1-3% of the population. The causes of MR are extremely heterogeneous and include non-genetic factors as well as genetic changes that include chromosomal abnormaliti ...
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 1

 TERMINÉ 

European Training Network on (+)RNA Virus Replication and Antiviral Drug Development (EUVIRNA)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Virus infections remain a major cause of disease, with dramatic costs in mortality, morbidity, and economic loss worldwide. There is an unmet need for potent antiviral drugs, in particular against viruses with a (+)RNA genome which include many important pathogens of humans and animals.Antiviral drug development requires a detailed understanding of virus replication and effective translation of th ...
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 12

 TERMINÉ 

Exploring the aggressiveness of prostate cancer to enable an individualised treatment approach (EXACTA)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,

Prostate cancer is the most frequently diagnosed malignancy in the western male population and the associated socio-economic impact on healthcare is more than worrying. There is one key feature of confined (stage T2) prostate cancer that needs to be addressed with immediate urgency: its true aggressiveness. Not all cancers are life threatening and early diagnosis, although needed to improve outcom ...
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 1

 TERMINÉ 

MicroRNA Networks in Neuronal Development and Plasticity (Neuro-miR-Networks)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

microRNAs (miRNAs) are novel gene circuitry regulators with an elusive role in neuronal development and plasticity. These small non-coding RNA molecules may explain some of the dysfunctional mechanisms in mental disorders, and are promising targets for diagnosis and treatment of neuropsychiatric disorders. I have recently identified pre-synaptically enriched miRNAs, of which miR-338 was found to m ...
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 1

 TERMINÉ 

TOWARDS THE ESTABLISHMENT OF A FRAMEWORK IN MALARIA BETWEEN THE AMRN AND EVIMALAR (Ozmalnet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

54 partners from 34 institutes have formed an EC-funded Network of Excellence (NoE) in basic malaria research, the European Virtual Institute for Malaria Research (EVIMalaR). Over the previous >5 years as the NoE Biomalpar these partners successfully broke down many barriers to cooperation pursuing a programme of integrated research. This was greatly assisted by the Biomalpar PhD School whose stud ...
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 14

 TERMINÉ 

Broadening the Bioinformatics Infrastructure to unicellular, animal, and plant science (ALLBIO)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The main aim of AllBio will be the coordination of the partner's activities that are aimed at the extension of a large number of bioinformatics facilities towards applicability in target life science areas beyond human health. Bioinformatics facilities developed for the human health area will be extensively tested on unicellular (incl. bacterial), plant and (farm) animal genomes, and they will be ...
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 11

 TERMINÉ 

"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices" (ALLFUN)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

"The ALLFUN proposal aims at defining the cellular and molecular mechanisms by which ubiquitous airborne or commensal fungi contribute to immune homeostasis and its dysregulation leading to allergy and inflammatory diseases. Breakthroughs in understanding how mucosal homeostasis is established, maintained or disrupted in the presence of fungi should be sources of new therapeutic targets and drugs ...
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 14

 TERMINÉ 

Molecular design of biologically inspired soft materials for hard tissue regeneration (PeptiDopaMin)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,

The shortcomings of current medical grafting procedures to treat severe bone defects continue to drive the development of alternative therapies. The clinical success of synthetic bone fillers is still disappointingly limited. Although hydrogels have not been classically studied for bone regeneration applications, owing to their inherently low mechanical properties, these highly hydrated soft mater ...
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 1

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services (EUROGENTEST2)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

EuroGentest is an FP6 European network for the harmonization of genetic testing and for the further improvement of quality in genetic services across Europe.This proposal is to support EuroGentest2, a Coordination Action that will cover the different aspects of quality assurance of genetic practice and has all the ingredients to fulfil the needs. EuroGentest2 will be concerned with setting the tar ...
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 22

 TERMINÉ 

A worldwide e-Infrastructure for NMR and structural biology (WeNMR)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2013,

Structural biology and life sciences in general, and NMR in particular, have always been associated with advanced computing. The current challenges in the post-genomic era, with their focus on biomolecular interactions, call for virtual research platforms that provide the worldwide research community with both user-friendly tools, platforms for data analysis and exchange, and an underlying e-infra ...
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 9

 TERMINÉ 

Prostate Research Organizations-Network of Early Stage Training (PRO-NEST)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) ...
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 18

 TERMINÉ 

Restoring Mueller glia cell – photoreceptor interactions with Crumbs (CRUMBS IN SIGHT)

Date du début: 1 avr. 2008, Date de fin: 31 mai 2012,

"Mutations in the Crumbs homologue 1 (CRB1) gene cause photoreceptor degeneration resulting in progressive retinitis pigmentosa (RP) or Leber congenital amaurosis (LCA), which both currently are untreatable blinding diseases. CRB1 is localized in Mueller glia cells at a subapical region (SAR) adjacent to adherens junctions between Mueller glia cells and photoreceptors. Loss of CRB1 function result ...
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 8