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9 projets européens trouvés

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 TERMINÉ 

Standardization and Development of Assays for Assessment of Influenza Vaccines Correlates of Protection (FLUCOP)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

Background: Influenza viruses cause annual epidemic and occasional pandemics, both of which induce significant morbidity and mortality. Influenza infections affect all age groups but children and adults over the age of 65 are at most risk of developing severe disease.Vaccination is the most effective approach to reduce the impact of annual influenza outbreaks and potential pandemics, however, the ...
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 26

 TERMINÉ 

Therapeutic TriMix / mRNA based Vaccine in Chronic HIV-1 Infected Patients Receiving Antiretroviral Therapy (IHIVARNA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

To find a therapy alternative to cART for life is one of the hot topics of investigation in HIV field. Therapeutic vaccination seems to be the best option. We have reported in a double-blind placebo controlled study some of the best, most solid data showing that HIV-1 specific immune responses elicited by therapeutic dendritic cell (DC) vaccines pulsed ex vivo with inactivated autologous whole vir ...
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 8

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

InFLUenza virus UNIVersal VACcine development program (FLUNIVAC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Effectively protecting the general population from seasonal and pandemic influenza has proven to be a challenge, since influenza viruses continue to escape from and evade immunity. Current influenza vaccines fail to provide long-lasting and broad protection against multiple strains of influenza. For the development of a universal influenza vaccine, we have to “do better than Nature”, since even na ...
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 8

 TERMINÉ 

Novel strategies to combat future influenza pandemics (FLUPLAN)

Date du début: 1 juin 2010, Date de fin: 31 mai 2015,

The Mexican influenza A virus (H1N1) reminds us that the threat of an influenza pandemic is real. The 1918 Spanish flu virus, also started as a low pathogenic virus that mutated into a highly pathogenic virus within months, causing more than 50 million deaths. The Mexican influenza A virus (H1N1) may follow the same path. FLUPLAN will expand our knowledge of the packaging signals that govern reass ...
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 1

 TERMINÉ 

Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

 TERMINÉ 

Pathogenesis and transmission of influenza virus in pigs (FLUPIG)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

"FLUPIG aims at a better understanding of the role of pigs in influenza pandemics. Pandemic influenza viruses come from wild birds, but they must adapt to efficient replication and transmission in humans to cause a pandemic. Pigs are considered important intermediate hosts in which avian viruses adapt to mammals before they transmit to humans. However, the exact role of pigs is unclear, as is the ...
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 10

 TERMINÉ 

Vector-borne Risks for Europe: Risk assessment and control of West Nile and Chikungunya virus (VECTORIE) (VECTORIE)

Date du début: 1 nov. 2010, Date de fin: 31 janv. 2014,

VECTORIE provides for a multidisciplinary approach combining the expertise of (basic) virology, entomology and advanced vaccinology to monitor the spread of and diagnose, prevent and treat infections caused by West Nile virus (WNV) and Chikungunya virus (CHIKV). VECTORIE therefore addresses Europe’s need to prepare for these vector-borne diseases along three strands:Vector biology: WNV and CHIKV a ...
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 9

 TERMINÉ 

ARCAS: Analysis of the Route to Commercialisation of MVA based influenza vaccines (ARCAS)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2013,

ARCAS will investigate the commercial potential and commercialization strategy of a platform of continuously updated repository of pandemic influenza vaccine candidates that was developed under the ERC project FLUPLAN. This platform is based on a novel vector technology using recombinant modified vaccinia virus Ankara (MVA) to develop pandemic influenza vaccines. There are two major advantages of ...
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 1