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11 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Roles of mitochondria in healthy and diseased myelin (MitoMyelin)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

Demyelinating peripheral neuropathies form a diverse group of pathologies that include diabetic and aging peripheral neuropathies and inherited Charcot-Marie-Tooth diseases. Mitochondrial dysfunctions have recently emerged as one major cause for these diseases. The goal of this project is to investigate the role of mitochondria in healthy and diseased myelin and to test whether we can change mitoc ...
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 1

 TERMINÉ 

Spine plasticity in changing environment and diseases (SPICED)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

Given the persistence of stress-related disorders, it is critical to identify the circuits, cells and mechanisms that fail to recover from stressor exposure. The stress hormone glucocorticoid causes reversible remodeling of brain circuits involved in cognitive, executive and hedonic behaviors. While small amounts of glucocorticoids support cognition and spine synapse turnover, excess stimulation b ...
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 2

 TERMINÉ 

Adoptive engineered T cell Trials to Achieve Cancer Killing (ATTACK)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

The aim of this research is to exploit technology for nucleic acid delivery through the clinical testing of adoptive engineered T cells to treat cancer. Recent innovative developments in cancer gene-immunotherapy have led to very encouraging early clinical results. However, the use of engineered T cells is a challenging and complex field with further development and more proof-of-principle trials ...
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 16

 TERMINÉ 

Beyond the Genome; training the next generation of ophthalmic researchers (EyeTN)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Eye research has often blazed a trail for other disciplines to follow, giving a lead in neuroscience, genetics, the development of gene- and stem-cell therapies and other important areas of medical research. In recent years, geneticists have made many remarkable discoveries of relevance both to normal human vision and the development of inherited retinal pathology. However the genes and mutations ...
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 7

 TERMINÉ 

Cell-type-specific identification of mRNAs translated by cannabinoids in the hippocampus: from signaling to behavior (CANCELLTRANS)

Date du début: 24 juin 2014, Date de fin: 23 juin 2016,

The hippocampal region is critically involved in memory formation and cannabinoids including delta9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, are known to impair hippocampus-dependent memories. Previous findings uncover the role of the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis underlying the long-term amnesic-like effects of THC. Th ...
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 1

 TERMINÉ 

Unveiling the Roles of Chromatin Insulators in Higher-order Chromatin Architecture and Transcription Regulation one molecule at a time (SMINSULATOR)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

Eukaryotic chromosomes are condensed into several hierarchical levels of complexity: DNA is wrapped around core histones to form nucleosomes, nucleosomes form a higher-order structure called chromatin, and chromatin is subsequently organized by long-range contacts. The conformation of chromatin at these three levels greatly influences DNA transcription. One class of chromatin regulatory proteins c ...
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 1

 TERMINÉ 

mechanisms of GABAergic interneurons axonal branching in developing cerebellum network (GABAXONETDEV)

Date du début: 1 août 2011, Date de fin: 31 juil. 2015,

"The appropriate wiring of neuronal circuits in mammalian brain forms the basis to generate, integrate, and process patterns of neuronal activity, which underlie perception and cognition.GABAergic inhibitory circuits consist of an array of interneuron cell types with distinct morphology, physiological properties, and synaptic connectivity patterns, and may constitute a scaffold to organize local c ...
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 1

 TERMINÉ 

Molecular mechanisms of myelination in peripheral nerves (HEALTHYMYELIN)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2015,

"Peripheral nerve myelination by Schwann cells is essential for normal nervous system function. Numerous acquired and inherited diseases result from defects in peripheral nerve myelination or myelin maintenance. In addition myelination is crucial for repair and regeneration of the nervous system. Thus an important challenge is to understand the cellular and molecular events that underlie myelinati ...
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 1

 TERMINÉ 

Bringing Regenerative Medicine into the market: Allogeneic eASCs Phase IB/IIA clinical trial for treating Rheumatoid Arthritis (REGENER-AR)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

Treating Rheumatoid Arthritis (RA) is a crucial challenge for the health systems. RA is the most common inflammatory arthritis, affecting 0.5% to 1% of the general population worldwide with little variation of the prevalence among countries.The current pharmacological management of RA involves early intervention with synthetic disease modifying anti-rheumatic drugs (DMARDs) either singly or in com ...
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 10

 TERMINÉ 

Dissemination of proneural brain cancer cells: implication of partial and reversible differentiation into Dcx+ cells (Dcxglioma)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,

Gliomas describe a range of devastating and progressive brain tumours affecting around 25000 people each year in Europe. Glioblastomas represent the most severe and frequent form of gliomas. A major finding in the field of glioblastomas is the recent identification of cancer stem cells within the tumour, holding a high tumorigenic potential. Those stem cell-like cancer cells are multipotent and re ...
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 1

 TERMINÉ 

Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers (EUROTRAPS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2011,

The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in c ...
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 9