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28 projets européens trouvés

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 TERMINÉ 

Counteracting psychosis by optimizing interaction (INTERACT)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting the core vulnerability profile of altered person-environment interactions underlying psychosis, specifically increased stre ...
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 3

 TERMINÉ 

Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing (FEMNAT-CD)

Date du début: 1 sept. 2013, Date de fin: 28 févr. 2018,

Conduct Disorder (CD) and Oppositional Defiant Disorder with symptoms of Conduct Disorder (which is included among the abbreviation “CD” throughout the proposal) has a highly negative impact for the affected individual as well as for families and society. Although the number of females exhibiting serious aggressive behaviours is growing, the majority of studies on aetiology and treatment of CD hav ...
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 19

 TERMINÉ 

Neoadjuvant Nanomedicines for vascular Normalization (NeoNaNo)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The aim of my proposal is to establish ‘Neoadjuvant Nanomedicines for vascular Normalization’ (NeoNaNo) as a novel concept for improving the efficacy of combined modality anticancer therapy. This concept is radically different from all other drug targeting approaches evaluated to date, since nanomedicines are not used to directly improve drug delivery to tumors, but to normalize the tumor vasculat ...
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 1

 TERMINÉ 

Systems medicine of chronic inflammatory bowel disease (SYSMEDIBD)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillat ...
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 13

 TERMINÉ 

Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases (D-BOARD)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

"Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in jo ...
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 15

 TERMINÉ 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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 17

 TERMINÉ 

Integrated DEsign and AnaLysis of small population group trials (IDEAL)

Date du début: 1 nov. 2013, Date de fin: 30 avr. 2017,

There exist more than 7000 rare diseases worldwide and the European Society of Paediatric Oncology stated that 75% of rare diseases affect children and 30% of rare disease patients die before the age of five. Usual statistical methods for proving efficacy and safety of therapies fail to provide cost-efficient and reliable results in small populations. There is a pressing need to integrate a broad ...
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 10

 TERMINÉ 

Towards Tissue Engineering Solutions for Cardiovascular Surgery (TECAS)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"The aim of the TECAS ITN is to integrate the major European contributors in the field of cardiovascular tissue engineering (TE) and regenerative medicine (RM), to generate a coherent framework of expertise which will facilitate the training and career development of early stage researchers (ESRs) in the field. In particular, the intention of this ITN is to focus on the clinical needs of cardiac v ...
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 7

 TERMINÉ 

Regional Anaesthesia Simulator and Assistant (RASimAs)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

Description RASimAs: Simulating anaesthesia outcomeA better outlook for those about to undergo surgery or have a child: The RASimAs project is working on a virtual reality simulator for doctors who are performing regional (or spinal) anaesthesia. This tool supports prediction and avoidance of possible complications during regional anaesth ...
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 11

 TERMINÉ 

Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (AMD) (TARGETAMD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Age-related Macular Degeneration (AMD), a neurodegenerative disease of the retina, is a major cause of blindness in elderly people. Due to the aging population, AMD has been referred to as a “time bomb” in society. In the exudative form of AMD, high levels of vascular endothelial cell growth factor (VEGF) and low levels of pigment-epithelial derived factor (PEDF), an inhibitor of vascularization a ...
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 16

 TERMINÉ 

Telemonitoring and Telemedicine for Hospitals Assisted by ICT for Life saving co-morbid patients in Europe As part of a Patient personalised care program of the EU (THALEA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

A growing body of evidence suggests outcome improvement in Intensive Care Unit (ICU) patients by means of telemedicine. At present a highly interoperable, manufacturer-independent telemedicine-platform for detection of ICU-patients at increased risk is missing. Encouraging results in other eHealth-projects influenced the decision to use pre-commercial procurement (PCP), in order to provide best p ...
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 8

 TERMINÉ 

A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)

Date du début: 1 août 2013, Date de fin: 31 juil. 2016,

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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 19

 TERMINÉ 

Markers for Sub-Clinical Cardiovascular Risk Assessemnt (EU-MASCARA)

Date du début: 1 déc. 2011, Date de fin: 31 mai 2016,

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existi ...
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 16

 TERMINÉ 

Structure-Function Analysis of the Chemokine Interactome for Therapeutic Targeting and Imaging in Atherosclerosis (ATHEROPROTECT)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2016,

Atherosclerosis is characterized by chronic inflammation of the arterial wall. Mononuclear cell recruitment is driven by chemokines that can be deposited e.g. by activated platelets on inflamed endothelium. Chemokines require oligomerization and immobilization for efficient function, and recent evidence supports the notion that heterodimer formation between chemokines constitutes a new regulatory ...
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 2

 TERMINÉ 

SAFER AND FASTER EVIDENCE-BASED TRANSLATION (SAFE-T)

Date du début: 15 juin 2009, Date de fin: 14 juin 2015,

The public-private consortium composed of complementary SMEs, academic and clinical centers of excellence and EMEA as partner proposes SAFE-T (Safer And Easter Evidence-based Iranslation) project for the establishment of a biomarker (BM) qualification process and its validation in clinical biomarker studies designed for the translation, performance testing and eventual regulatory qualifIcatIon of ...
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 26

 TERMINÉ 

European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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 15

 TERMINÉ 

Brain-inspired multiscale computation in neuromorphic hybrid systems (BrainScaleS)

Date du début: 1 janv. 2011, Date de fin: 31 mars 2015,

The BrainScaleS project aims at understanding function and interaction of multiple spatial and temporal scales in brain information processing. The fundamentally new approach of BrainScaelS lies in the in-vivo biological experimentation and computational analysis. Spatial scales range from individual neurons over larger neuron populations to entire functional brain areas. Temporal scales range fro ...
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 17

 TERMINÉ 

Development & Evaluation of a Viable Stent Device for the Treatment of BronchoTracheal Cancer (PULMOSTENT)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2015,

Lung cancer is the most common cancer in terms of both incidence and mortality, worldwide. With a median age at diagnosis of 71, lung cancer is mainly affecting the aging population. Airway stenosis is a key problem with significant morbidity and premature death. Endobronchial stenting is a proven therapy to keep the airways open. Nevertheless the currently used clinical stents have major disadvan ...
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 8

 TERMINÉ 

THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA (LIPIDIDIET)

Date du début: 1 août 2008, Date de fin: 31 mars 2015,

Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of the ...
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 19

 TERMINÉ 

SUB nanosecond Leverage In PET/MR ImAging (SUBLIMA)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2015,

The SUBLIMA project aims at truly simultaneous, fully integrated, solid-state PET/MR technology for concurrent functional and anatomical imaging with unsurpassed image quality. It will combine the extremely sensitive functional imaging possibilities provided by PET with the excellent soft-tissue contrast and complementary functional imaging capabilities of MR. For the first time, time-of-flight (T ...
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 14

 TERMINÉ 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

 TERMINÉ 

Warehousing images in the digital hospital (WIDTH): interpretation, infrastructure, and integration (WIDTH)

Date du début: 16 mai 2011, Date de fin: 15 déc. 2014,

Advanced information communications technology (ICT) has created an expectation that the innovative use of ICT can deliver high quality healthcare to a situation where patients’ data can be supplied seamlessly to support clinical decisions. The world however has moved beyond the current reactive model and hamstrung by the problems of fragmentation and lack of coordination. Medical images are of a ...
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 7

 TERMINÉ 

Access to Opioid Medication in Europe (ATOME)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2014,

"Medicines derived from opium are very valuable in medicine practice & therefore regarded as essential medicines. However, they are generally not readily available for patients who are in need of them for medical reasons. It is estimated that over 80% of the world's population is inadequately treated, because opioid (pain relieving) medicines have been categorized as ""controlled substances"", du ...
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 11

 TERMINÉ 

The Function of inflammatory signalling pathways in acute and chronic liver disease and liver cancer (LUEDDE-MED3-AACHEN)

Date du début: 1 sept. 2008, Date de fin: 31 août 2014,

The aim of this proposal is to examine the role of inflammatory signalling pathways in murine models of liver and biliary disease by application of conditional gene targeting using cre/loxP technology. Previous studies have provided evidence that the NF-kB pathway and its activating kinase complex – consisting of three subunits: IKK1, IKK2 and NEMO – are crucial regulators of liver physiology and ...
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 1

 TERMINÉ 

Combating Antibiotics Resistant Pneumococci by Novel Strategies Based on in vivo and in vitro Host – Pathogen Interactions (CAREPNEUMO)

Date du début: 1 mars 2009, Date de fin: 29 févr. 2012,

"The diseases caused by Streptococcus pneumoniae are a major public health problem all over the world. Children, elderly people and immuno-compromised individuals are the high-risk targets for pneumococcal diseases. In spite of the availability of a large number of antibiotics the mortality and morbidity due to S. pneumoniae infections remain very high. There are two reasons for this: Firstly, the ...
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 13

 TERMINÉ 

Emergence of communication in RObots through Sensorimotor and Social Interaction (ROSSI)

Date du début: 1 mars 2008, Date de fin: 31 oct. 2011,

Description Robots endowed with neural/computational mechanisms and sensorimotor systems structurally similar to human beings The ROSSI project addresses the question how the possibility of communication between agents (e.g. humans and robots) is affected by differences in sensorimotor capacities. ...
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 7

 TERMINÉ 

Set up and comparison of multiple stem cell approaches for kidney repair (STAR-T REK)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,

"With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potent ...
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 11