6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Aberrant Splicing of CFTR Exon 9 (ASCE)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
Alternative splicing of pre-mRNAs is tightly regulated and any imbalance can change the outcome of gene expression which often leads to disease. Despite the importance of alternative splicing regulation our knowledge at the molecular level is still in its infancy hampering development of effective therapies. We plan to study the regulatory RNA-protein and protein-protein interaction networks leadi ...
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1
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TERMINÉ
Structural studies of Nucleotide Excision Repair for drug development targeting protein-DNA interactions (NER)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
Numerous DNA repair pathways are required for genomic stability and chromosome maintenance. XPF/ERCC1 protein complex is an evolutionally conserved structure-specific endonuclease involved in nucleotide excision repair (NER) and other DNA repair pathways, making it essential for viability. The pleiotropic phenotypes of XPF/ERCC1 deficiency in humans range from cancer-predisposition to accelerated ...
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1
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TERMINÉ
Environmentally Controlled Polymorphism of non-B DNA structures (ECOPOD)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
Repetitive blocks of guanine- and cytosine-rich sequences, such as those occurring in centromeric and telomeric DNA regions and promoter regions of protein coding genes, have ability to form G- and C-quadruplex structures, respectively. These non-B DNA structures are involved in more than 40 pathological human conditions including cancer. From a biophysical point of view, a common property to both ...
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1
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TERMINÉ
NMR for Structural Biology (Bio-NMR)
Date du début: 1 sept. 2010, Date de fin: 31 août 2014,
In the past two decades spectacular insight into basic principles of life has been obtained from paradigmatic high-resolution structural investigations providing a rational basis for biological experiments. NMR is an indispensable enabling technology for determining such structures and their interactions in solution, the immobilized state and living cells. The power of NMR to link structural, dyna ...
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20
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TERMINÉ
Allosteric effects induced in 14-3-3 targets (14_3_3)
Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,
"14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 300 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active c ...
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1
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TERMINÉ
Enhancing Access and Services To East European users towards an efficient and coordinated panEuropean pool of NMR capacities to enable global collaborative research & boost technological advancements (EAST-NMR)
Date du début: 1 févr. 2009, Date de fin: 31 janv. 2013,
"Nuclear magnetic resonance (NMR) spectroscopy is a key technology for research in the modern Life Sciences, with an increasing impact on human health. This technology is unique in new areas of molecular systems biology providing detailed insight into protein-protein and protein-ligand interactions. NMR Research Infrastructures (RIs) are of primary importance here; they offer the resources necessa ...
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