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11 projets européens trouvés

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 TERMINÉ 

Dissecting the Molecular Mechanism of Catastrophic DNA Rearrangement in Cancer (CHROMOTHRIPSIS)

Date du début: 1 avr. 2014, Date de fin: 31 janv. 2019,

Recent cancer genome analyses have led to the discovery of a process involving massive genome structural rearrangement (SR) formation in a one-step, cataclysmic event, coined chromothripsis. The term chromothripsis (chromo from chromosome; thripsis for shattering into pieces) stands for a hypothetical process in which individual chromosomes are pulverised, resulting in a multitude of fragments, so ...
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 1

 TERMINÉ 

Development of chemical biology tools for the elucidation of protein phosphatase-1 substrates and druggability (PP1TOOLS)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Protein serine/threonine phosphatases (PSTPs) are considered undruggable although they are involved in the most prominent post-translational modifications. This is mainly due to an apparent lack of substrate specificity. One important PSTP is protein phosphatase-1 (PP1), a ubiquitous PSTP that is predicted to catalyze about 1/3rd of Ser and Thr dephosphorylations in eukaryotic cells, counteracting ...
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 2

 TERMINÉ 

Cis-regulatory variation: Using natural genetic variation to dissect cis-regulatory control of embryonic development (CISREGVAR)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Embryonic development is very robust: In the midst of segregating mutations and fluctuating environments, a fertilized egg has the remarkable capacity to give rise to a precisely patterned embryo. The stereotypic progression of development is driven by tightly regulated programs of gene expression. However, this deterministic view from genetics is at odds with an emerging view of transcription fro ...
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 1

 TERMINÉ 

High-throughput dissection of the genetics underlying complex traits (COMPLEX_TRAITS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

The vast majority of genetic diseases are complex traits, conditioned by multiple genetic and environmental factors. Yet our understanding of the genetics underlying such traits in humans remains extremely limited, due largely to the statistical complexity of inferring the effects of allelic variants in a genetically diverse population. Novel tools for the dissection of the genetic architecture o ...
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 1

 TERMINÉ 

Rapid development and distribution of statistical tools for high-throughput sequencing data (RADIANT)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,

"High-throughput sequencing (HTS) is a powerful and rapidly evolving family of technologies with a multitude of applications. They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcr ...
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 10

 TERMINÉ 

Coordinated Access to Lightsources to Promote Standards and Optimization (CALIPSO)

Date du début: 1 juin 2012, Date de fin: 31 mai 2015,

CALIPSO coordinates the European synchrotrons and FELs, including the three ESFRI roadmap projects European XFEL, EuroFEL and the ESRF Upgrade Programme, towards a fully integrated network. The consortium is characterised by common objectives, harmonised decisions, transnational open access based on excellence and joint development of new instruments. Innovative networking initiatives address user ...
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 20

 TERMINÉ 

Genetic mapping of complex trait intermediates (IntGenMap)

Date du début: 1 mars 2013, Date de fin: 31 mai 2015,

Many important traits are heritable, and have a strong genetic component. Numerous genome-wide association studies of common human diseases have corroborated that no single gene explains all or even a large part of their heritable variability. Each effect of a single locus genotype on such a global trait has to be mediated by cellular, tissue, and organ phenotypes. Thus, genetics of intermediate c ...
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 1

 TERMINÉ 

Non-coding RNAs and their role in developmental networks (ncRNAsDevNet)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

With the availability of new technologies, it is now feasible to complete regulatory networks controlling complex developmental programs and understand their logic, which can improve considerably the success of diagnosis and therapies for diseases related to development or cancer. However, in order to fully understand how gene expression is regulated, epigenetic aspects need to be identified and i ...
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 1

 TERMINÉ 

Dissecting Cancer Development by Chromothripsis Using Cell-Based Models (BRM CHROMOTHRIPSIS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

"Cancer is commonly thought as a progressive process, requiring accumulation of many mutations over time. Recently, this conventional view of cancer progression has been challenged with the discovery of a phenomenon called chromothripsis, whereby tens to hundreds of chromosomal rearrangements occur in a single catastrophic event. Despite the growing amount of sequencing data that sheds some light ...
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 1

 TERMINÉ 

Helix Nebula - The Science Cloud (Helix Nebula)

Date du début: 1 juin 2012, Date de fin: 31 mai 2014,

Data capture, processing, analysis and archiving is central to scientific endeavour, challenging the sustainability of an approach to ICT deployment that has predominated for 25 years but is rapidly being overtaken by events. Cloud-based services offer greater efficiency, agility and innovation in delivery of services through economies of scale, multiple tenancy of irregularly-used resources and m ...
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 11

 TERMINÉ 

REM networks in yeast (yREM)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

The interconnections between intermediary metabolism and regulation of gene expression are relatively poorly understood. A few reports have analysed the ability of some metabolic enzymes to 'moonlight' as RNA-binding proteins, being responsive to small metabolites that often represent co-factors of the enzymes. Building on these observations, it was recently proposed that regulatory networks forme ...
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 1