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TERMINÉ
LINE-1 ACTIVITY IN SOMATIC STEM CELLS: IMPACT AND GENOMIC MOSAICISM (SOMATIC LINE-1)
Date du début: 24 juin 2008, Date de fin: 23 juin 2012,
"45% of the human genome is made of repeated DNA, and some types can be mobilized within the genome (mobile DNA). LINE-1 or L1 is the only autonomous active mobile DNA within the human genome, with 500.000 copies per haploid genome (~17% of the genome). Overall, L1 is responsible for ~30% of our genome. Due to its activity and number in the genome, the impact that L1 has and have on the genome is ...
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TERMINÉ
Developmental Impact of MLL-AF4 Fusion Gene linked to Infant Acute Lymphoblastic Leukaemia on Human Stem Cell Fate (Leukaemogenesis)
Date de fin: 1 sept. 2009,
The MLL gene is located in chromosome 11q23 and is implicated in >40 different chromosomal translocations, generating distinct leukaemic fusion genes. Unlike other MLL fusion proteins, t(4;11) MLL-AF4 is always found in infant pro-B-ALL with a dismal prognosis in infants and adults. In infant ALL where t(4;11) MLL-AF4 is very common (>80%), the gene fusion arises in utero. However, very litt ...
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