4 projets européens trouvés
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TERMINÉ
Structural studies of human picornaviruses (PICOSTRUCTURE)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"Many picornaviruses are human pathogens that cause diseases varying in symptoms from common cold to life-threatening encephalitis. Currently there are no anti-picornavirus drugs approved for human use. We propose to study molecular structures of picornaviruses and their life cycle intermediates in order to identify new targets for anti-viral inhibitors and to lay the foundations for structure-bas ...
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TERMINÉ
Detailed binding scheme and structural determination of the 14-3-3ζ in complex with a double phosphorylated human tyrosine hydroxylase 1 (MODULATOR)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
"14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 850 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active c ...
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TERMINÉ
Structure, maturation and cell entry mechanisms of ranavirus virions (StruRANA)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
The long-term goal of this proposal is to understand the molecular mechanisms of the replication cycle ofnucleocytoplasmic large DNA viruses that attracted attention after the discovery of the giant Mimivirus adecade ago. Here, we focus on ranaviruses from the family Iridoviridae that have caused large economiclosses in Europe and Asia and threaten wildlife biodiversity worldwide. The ranavirus di ...
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TERMINÉ
Structural and kinetic studies of XPF/ERCC1-DNA complex for drug discovery (XPF-ERCC1)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2016,
"Cancer chemotherapeutic drugs, such as platinum agents, work by producing DNA damage that causes cell-cycle arrest and cell death. However, DNA repair pathways can enable tumour cells to survive DNA damage induced by chemotherapeutic treatments. Platinum resistance is a major clinical problem in cancer treatment and there is a considerable interest in inhibitors of DNA repair pathways, that can i ...
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